Incidental Mutation 'IGL01861:Or8b41'
ID 178315
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b41
Ensembl Gene ENSMUSG00000096409
Gene Name olfactory receptor family 8 subfamily B member 41
Synonyms Olfr890, MOR162-15_p, MOR162-3, GA_x6K02T2PVTD-31822365-31823309
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL01861
Quality Score
Status
Chromosome 9
Chromosomal Location 38054433-38055377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38055046 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 205 (I205T)
Ref Sequence ENSEMBL: ENSMUSP00000078733 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]
AlphaFold Q7TRD9
Predicted Effect probably damaging
Transcript: ENSMUST00000079804
AA Change: I205T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: I205T

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 2.3e-48 PFAM
Pfam:7tm_1 46 293 9.6e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213087
AA Change: I200T
Predicted Effect probably damaging
Transcript: ENSMUST00000213458
AA Change: I200T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arrdc5 T C 17: 56,607,144 (GRCm39) T34A possibly damaging Het
Atm C A 9: 53,405,912 (GRCm39) R1252L probably null Het
Cd34 T C 1: 194,640,888 (GRCm39) probably benign Het
Cmya5 A G 13: 93,226,256 (GRCm39) V2944A probably damaging Het
Cntnap3 C T 13: 64,946,922 (GRCm39) G169D probably damaging Het
Dnah7a T A 1: 53,679,508 (GRCm39) T326S probably benign Het
Dnah7a C T 1: 53,623,608 (GRCm39) probably benign Het
Fam133b A G 5: 3,614,242 (GRCm39) probably benign Het
Fhod1 A G 8: 106,057,808 (GRCm39) S906P probably damaging Het
Gli3 A G 13: 15,899,910 (GRCm39) Y1099C probably damaging Het
Gpr63 C T 4: 25,008,545 (GRCm39) T423M probably damaging Het
Hpx A T 7: 105,241,393 (GRCm39) Y339* probably null Het
Lingo2 A T 4: 35,709,526 (GRCm39) D151E probably benign Het
Mill2 A T 7: 18,590,565 (GRCm39) Q215L probably damaging Het
Naf1 T C 8: 67,317,185 (GRCm39) probably benign Het
Ndufv1 A G 19: 4,058,803 (GRCm39) V235A probably benign Het
Pafah1b1 A T 11: 74,581,403 (GRCm39) N22K possibly damaging Het
Prune1 G T 3: 95,172,868 (GRCm39) R66S probably damaging Het
Ptcd1 A T 5: 145,095,587 (GRCm39) I291N possibly damaging Het
Ptprk A G 10: 28,259,441 (GRCm39) I294V possibly damaging Het
Rfx6 G A 10: 51,597,675 (GRCm39) V471M probably damaging Het
Rnase6 C A 14: 51,367,748 (GRCm39) Q47K probably benign Het
Skint5 T C 4: 113,417,021 (GRCm39) probably benign Het
Srcap T A 7: 127,124,457 (GRCm39) probably benign Het
Stap1 A G 5: 86,244,383 (GRCm39) I217V possibly damaging Het
Taf1d T C 9: 15,220,035 (GRCm39) probably null Het
Tecta T C 9: 42,284,658 (GRCm39) H809R probably benign Het
Tex15 A G 8: 34,060,717 (GRCm39) N49S probably damaging Het
Tubb4b-ps1 A G 5: 7,229,374 (GRCm39) probably benign Het
Uhrf2 A G 19: 30,063,804 (GRCm39) Y589C probably damaging Het
Zfp616 A T 11: 73,973,742 (GRCm39) T4S possibly damaging Het
Zfp687 A T 3: 94,919,171 (GRCm39) F200L probably damaging Het
Other mutations in Or8b41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Or8b41 APN 9 38,055,167 (GRCm39) nonsense probably null
IGL02174:Or8b41 APN 9 38,055,081 (GRCm39) missense possibly damaging 0.90
IGL02723:Or8b41 APN 9 38,054,707 (GRCm39) missense probably benign 0.02
IGL03085:Or8b41 APN 9 38,054,479 (GRCm39) missense probably damaging 0.98
FR4449:Or8b41 UTSW 9 38,054,484 (GRCm39) missense probably benign 0.00
FR4737:Or8b41 UTSW 9 38,054,484 (GRCm39) missense probably benign 0.00
R0637:Or8b41 UTSW 9 38,055,178 (GRCm39) missense probably benign 0.00
R1353:Or8b41 UTSW 9 38,055,024 (GRCm39) missense probably benign 0.03
R1813:Or8b41 UTSW 9 38,055,025 (GRCm39) missense possibly damaging 0.78
R5997:Or8b41 UTSW 9 38,055,097 (GRCm39) missense probably damaging 1.00
R6004:Or8b41 UTSW 9 38,055,256 (GRCm39) missense probably damaging 1.00
R6417:Or8b41 UTSW 9 38,054,611 (GRCm39) missense probably damaging 1.00
R6420:Or8b41 UTSW 9 38,054,611 (GRCm39) missense probably damaging 1.00
R6720:Or8b41 UTSW 9 38,054,449 (GRCm39) start codon destroyed probably null 1.00
R7223:Or8b41 UTSW 9 38,055,049 (GRCm39) missense probably benign 0.02
R7601:Or8b41 UTSW 9 38,054,674 (GRCm39) missense probably benign 0.13
R7671:Or8b41 UTSW 9 38,054,736 (GRCm39) missense probably benign 0.02
R8034:Or8b41 UTSW 9 38,054,973 (GRCm39) missense probably damaging 1.00
R8356:Or8b41 UTSW 9 38,054,981 (GRCm39) nonsense probably null
R8456:Or8b41 UTSW 9 38,054,981 (GRCm39) nonsense probably null
R8696:Or8b41 UTSW 9 38,054,433 (GRCm39) start codon destroyed probably null 0.00
R9487:Or8b41 UTSW 9 38,054,866 (GRCm39) missense probably benign 0.22
R9517:Or8b41 UTSW 9 38,054,623 (GRCm39) missense probably damaging 1.00
Z1176:Or8b41 UTSW 9 38,054,727 (GRCm39) missense probably benign 0.02
Posted On 2014-05-07