Incidental Mutation 'R0108:Gm136'
ID17832
Institutional Source Beutler Lab
Gene Symbol Gm136
Ensembl Gene ENSMUSG00000071015
Gene Namepredicted gene 136
SynonymsLOC214568
MMRRC Submission 038394-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #R0108 (G1)
Quality Score
Status Validated
Chromosome4
Chromosomal Location34743784-34756263 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 34746593 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 139 (H139Q)
Ref Sequence ENSEMBL: ENSMUSP00000092748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095129]
Predicted Effect possibly damaging
Transcript: ENSMUST00000095129
AA Change: H139Q

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000092748
Gene: ENSMUSG00000071015
AA Change: H139Q

DomainStartEndE-ValueType
low complexity region 72 83 N/A INTRINSIC
coiled coil region 119 189 N/A INTRINSIC
coiled coil region 223 251 N/A INTRINSIC
Meta Mutation Damage Score 0.076 question?
Coding Region Coverage
  • 1x: 87.1%
  • 3x: 81.7%
  • 10x: 58.7%
  • 20x: 25.7%
Validation Efficiency 90% (92/102)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,177,918 N910K probably benign Het
Ackr4 T A 9: 104,099,188 I187F probably benign Het
Adamts12 T C 15: 11,311,098 V1147A probably benign Het
Adcy2 A T 13: 68,651,935 V858E probably damaging Het
Adgrv1 A G 13: 81,578,404 probably benign Het
Atg4c C T 4: 99,221,440 H215Y possibly damaging Het
Ccdc88a T A 11: 29,503,463 S337T probably damaging Het
Evpl T C 11: 116,220,876 E1996G probably damaging Het
Fbxw10 A G 11: 62,877,061 T903A probably benign Het
Frem2 G T 3: 53,647,961 D1718E probably benign Het
Gatad2b T A 3: 90,357,943 Y576N probably damaging Het
Helq C A 5: 100,768,368 E913* probably null Het
Itgb7 C T 15: 102,223,482 R222H probably damaging Het
Lmtk2 C T 5: 144,174,285 R608C possibly damaging Het
Lonp2 G A 8: 86,716,355 V815I probably benign Het
Mpdz C T 4: 81,381,805 V319I probably damaging Het
Ntng1 T C 3: 109,851,755 probably benign Het
Nup210l A G 3: 90,189,575 T1364A probably damaging Het
Olfr1491 A T 19: 13,705,678 T284S probably damaging Het
Pcdha1 T A 18: 36,998,756 W293R probably benign Het
Plcl1 A G 1: 55,697,939 Y813C possibly damaging Het
Plekho2 A T 9: 65,559,423 D128E probably damaging Het
Pstpip1 A G 9: 56,127,766 E341G probably benign Het
Rps6ka2 G A 17: 7,296,043 D617N probably benign Het
Scin A G 12: 40,127,987 V83A possibly damaging Het
Sec11a A G 7: 80,935,039 V50A probably damaging Het
Sel1l3 C T 5: 53,137,902 A786T possibly damaging Het
Shroom1 T C 11: 53,466,937 S772P possibly damaging Het
Slc30a5 G T 13: 100,803,400 A669E probably damaging Het
Tm6sf1 G A 7: 81,865,345 probably null Het
Ttll4 G T 1: 74,679,769 V260L probably benign Het
Zfand3 A G 17: 30,135,398 E63G probably damaging Het
Other mutations in Gm136
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Gm136 APN 4 34752322 missense probably damaging 1.00
R0104:Gm136 UTSW 4 34746593 missense possibly damaging 0.65
R1221:Gm136 UTSW 4 34744127 missense possibly damaging 0.71
R1635:Gm136 UTSW 4 34750919 critical splice donor site probably null
R1674:Gm136 UTSW 4 34746662 splice site probably benign
R1971:Gm136 UTSW 4 34755986 missense probably benign 0.00
R2496:Gm136 UTSW 4 34746541 missense probably damaging 1.00
R4441:Gm136 UTSW 4 34755911 missense probably benign 0.35
R4901:Gm136 UTSW 4 34746580 nonsense probably null
R5300:Gm136 UTSW 4 34750930 missense probably damaging 0.98
R6609:Gm136 UTSW 4 34746526 missense probably benign
R6709:Gm136 UTSW 4 34755884 missense probably damaging 1.00
R6824:Gm136 UTSW 4 34746591 missense probably benign 0.15
R7098:Gm136 UTSW 4 34746628 missense probably benign 0.08
Posted On2013-03-25