Mutagenetix > Incidental Mutation

Incidental Mutation 'R0107:Zftraf1'

17836

Institutional Source

Beutler Lab

Gene Symbol

Zftraf1

Ensembl Gene

ENSMUSG00000053929

Gene Name

zinc finger TRAF type containing 1

Synonyms

Cyhr1, Chrp, 1110031M01Rik

MMRRC Submission

038393-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.274) question?

Stock #

R0107 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

76527586-76541120 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 76530547 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 258 (D258N)

Ref Sequence

ENSEMBL: ENSMUSP00000080043 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081291] [ENSMUST00000176274] [ENSMUST00000229524]

AlphaFold

Q9QXA1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000081291
AA Change: D258N

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000080043
Gene: ENSMUSG00000053929
AA Change: D258N

Domain	Start	End	E-Value	Type
SCOP:d1jm7a_	21	88	3e-5	SMART
Blast:RING	27	62	8e-15	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000176274

SMART Domains

Protein: ENSMUSP00000134739
Gene: ENSMUSG00000053929

Domain	Start	End	E-Value	Type
low complexity region	3	48	N/A	INTRINSIC
low complexity region	78	91	N/A	INTRINSIC
RING	106	150	1.9e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000229524

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229541

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229552

Meta Mutation Damage Score

0.0788

Coding Region Coverage

10x: 7.6%
20x: 2.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 3 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Chuk	T	A	19: 44,085,358 (GRCm39)	S263C	probably damaging	Het
Fut1	C	A	7: 45,268,270 (GRCm39)	Q20K	possibly damaging	Het
Tmem184c	A	G	8: 78,323,702 (GRCm39)	S387P	possibly damaging	Het

Other mutations in Zftraf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00093:Zftraf1	APN	15	76,530,738 (GRCm39)	missense	probably damaging	1.00
IGL03163:Zftraf1	APN	15	76,543,474 (GRCm39)	missense	probably damaging	0.97
R0445:Zftraf1	UTSW	15	76,532,457 (GRCm39)	missense	probably damaging	1.00
R0759:Zftraf1	UTSW	15	76,530,385 (GRCm39)	makesense	probably null
R1327:Zftraf1	UTSW	15	76,533,376 (GRCm39)	missense	probably damaging	0.98
R1366:Zftraf1	UTSW	15	76,533,169 (GRCm39)	missense	probably damaging	0.96
R1950:Zftraf1	UTSW	15	76,543,417 (GRCm39)	critical splice donor site	probably null
R3416:Zftraf1	UTSW	15	76,542,915 (GRCm39)	splice site	probably null
R5092:Zftraf1	UTSW	15	76,530,512 (GRCm39)	missense	probably benign	0.11
R5749:Zftraf1	UTSW	15	76,542,844 (GRCm39)	splice site	probably null
R5860:Zftraf1	UTSW	15	76,540,615 (GRCm39)	missense	probably damaging	1.00
R5860:Zftraf1	UTSW	15	76,532,391 (GRCm39)	missense	probably damaging	1.00
R6032:Zftraf1	UTSW	15	76,543,058 (GRCm39)	missense	probably damaging	0.99
R6032:Zftraf1	UTSW	15	76,543,058 (GRCm39)	missense	probably damaging	0.99
R6397:Zftraf1	UTSW	15	76,532,391 (GRCm39)	missense	probably damaging	1.00
R6481:Zftraf1	UTSW	15	76,542,908 (GRCm39)	splice site	probably null
R6533:Zftraf1	UTSW	15	76,531,930 (GRCm39)	nonsense	probably null
R7466:Zftraf1	UTSW	15	76,532,386 (GRCm39)	missense	probably benign	0.29
R7484:Zftraf1	UTSW	15	76,530,435 (GRCm39)	missense	probably damaging	1.00
R7629:Zftraf1	UTSW	15	76,532,386 (GRCm39)	missense	probably benign	0.29
R7732:Zftraf1	UTSW	15	76,532,386 (GRCm39)	missense	probably benign	0.29
R7763:Zftraf1	UTSW	15	76,542,747 (GRCm39)	missense	probably damaging	0.99
R7861:Zftraf1	UTSW	15	76,532,386 (GRCm39)	missense	probably benign	0.29
R9300:Zftraf1	UTSW	15	76,530,541 (GRCm39)	missense	probably benign	0.05

Posted On

2013-03-25