Incidental Mutation 'IGL01866:Ear10'
ID178498
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ear10
Ensembl Gene ENSMUSG00000090166
Gene Nameeosinophil-associated, ribonuclease A family, member 10
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.149) question?
Stock #IGL01866
Quality Score
Status
Chromosome14
Chromosomal Location43922720-43923559 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 43923328 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 14 (L14P)
Ref Sequence ENSEMBL: ENSMUSP00000130933 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159175] [ENSMUST00000160298] [ENSMUST00000163652]
Predicted Effect probably damaging
Transcript: ENSMUST00000159175
AA Change: L14P

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000123872
Gene: ENSMUSG00000090166
AA Change: L14P

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RNAse_Pc 27 156 9.52e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160298
SMART Domains Protein: ENSMUSP00000125038
Gene: ENSMUSG00000089901

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
low complexity region 365 404 N/A INTRINSIC
transmembrane domain 530 552 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000163652
AA Change: L14P

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130933
Gene: ENSMUSG00000090166
AA Change: L14P

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RNAse_Pc 27 156 9.52e-58 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430007A20Rik T C 4: 144,528,549 Y180H possibly damaging Het
Abi3bp A T 16: 56,671,973 I1361L probably benign Het
Amph A T 13: 19,142,002 D634V probably damaging Het
Ank1 G A 8: 23,093,855 V317I possibly damaging Het
Ap4e1 G A 2: 127,046,910 V460I possibly damaging Het
Arhgap19 A T 19: 41,786,577 H198Q probably benign Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cacna1g C T 11: 94,457,111 G717D probably damaging Het
Camkk2 A G 5: 122,763,950 S99P probably damaging Het
Catsperb T A 12: 101,509,311 Y371* probably null Het
Cbl A T 9: 44,153,825 C735* probably null Het
Ccdc146 C A 5: 21,333,054 A91S probably damaging Het
Col1a2 G T 6: 4,524,132 D531Y probably damaging Het
Dscam T A 16: 96,685,350 T1042S probably benign Het
Dtnb A G 12: 3,732,626 Y363C probably benign Het
Egf A G 3: 129,735,880 S294P probably benign Het
Erbb3 T C 10: 128,569,368 *1340W probably null Het
Fam217b A G 2: 178,420,431 T63A probably benign Het
Fig4 G A 10: 41,232,164 P680L possibly damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm6882 T A 7: 21,427,587 I119F probably damaging Het
Hdac10 C A 15: 89,124,533 G442W probably damaging Het
Mc2r C T 18: 68,407,423 M266I possibly damaging Het
Mep1b A G 18: 21,094,993 Q551R probably benign Het
Mtrf1 T A 14: 79,401,508 C27S probably benign Het
Myo5c T A 9: 75,269,582 M603K probably benign Het
Nuf2 A G 1: 169,498,838 L448P possibly damaging Het
Olfr1535 T C 13: 21,555,173 N283S probably benign Het
Olfr390 A T 11: 73,787,828 I297L probably benign Het
Olfr517 C T 7: 108,868,799 M118I possibly damaging Het
Olfr952 A T 9: 39,426,729 M114K probably damaging Het
Ppp2r5c T C 12: 110,567,827 Y375H probably benign Het
Pstpip2 A G 18: 77,877,625 I317M probably benign Het
Pxdn A G 12: 29,984,571 T208A probably benign Het
Rab3gap1 C T 1: 127,891,080 H116Y probably damaging Het
Rarb T A 14: 16,443,751 D179V probably benign Het
Rasal1 G A 5: 120,675,423 A621T probably damaging Het
Rnf6 G A 5: 146,210,907 R434C probably damaging Het
Scn10a C A 9: 119,635,502 E1011* probably null Het
Sec24d C T 3: 123,293,595 Q137* probably null Het
Slc35g1 C A 19: 38,403,194 A308E probably damaging Het
Smtnl1 C A 2: 84,818,745 C55F possibly damaging Het
Stt3a A T 9: 36,734,366 D676E probably benign Het
Sytl2 T C 7: 90,381,839 probably benign Het
Trabd2b A G 4: 114,408,920 T44A probably damaging Het
Trim12a T C 7: 104,304,153 probably benign Het
Tti1 A T 2: 158,007,698 D540E probably benign Het
Tubgcp6 A G 15: 89,103,488 V1094A probably benign Het
Vmn1r34 A G 6: 66,637,389 Y122H probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp579 T A 7: 4,994,258 Q218L possibly damaging Het
Other mutations in Ear10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02867:Ear10 APN 14 43923269 missense probably damaging 0.99
IGL02889:Ear10 APN 14 43923269 missense probably damaging 0.99
IGL02962:Ear10 APN 14 43923317 missense probably damaging 1.00
R0636:Ear10 UTSW 14 43922994 synonymous probably null
R1924:Ear10 UTSW 14 43922900 makesense probably null
R4289:Ear10 UTSW 14 43922947 missense probably benign 0.00
R6351:Ear10 UTSW 14 43923055 missense probably damaging 1.00
Posted On2014-05-07