Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01867:Mos'

178563

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mos

Ensembl Gene

ENSMUSG00000078365

Gene Name

Moloney sarcoma oncogene

Synonyms

c-mos

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01867

Quality Score

Status

Chromosome

Chromosomal Location

3870658-3872105 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 3870845 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 324 (Q324K)

Ref Sequence

ENSEMBL: ENSMUSP00000100789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105158]

AlphaFold

P00536

Predicted Effect

probably benign
Transcript: ENSMUST00000105158
AA Change: Q324K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365
AA Change: Q324K

Domain	Start	End	E-Value	Type
low complexity region	39	54	N/A	INTRINSIC
Pfam:Pkinase_Tyr	63	335	9e-41	PFAM
Pfam:Pkinase	64	334	6.3e-43	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	T	C	17: 46,635,364 (GRCm39)	E213G	probably benign	Het
Akap6	T	C	12: 52,934,791 (GRCm39)	L761P	probably damaging	Het
Bbs7	A	C	3: 36,627,696 (GRCm39)	L697R	probably benign	Het
Cd74	G	A	18: 60,941,352 (GRCm39)	R99H	probably benign	Het
Cpne6	A	G	14: 55,751,137 (GRCm39)	N182S	probably benign	Het
Cyp4f17	A	G	17: 32,747,057 (GRCm39)	H429R	probably benign	Het
Dact2	A	T	17: 14,415,932 (GRCm39)	M756K	probably damaging	Het
Ets1	A	G	9: 32,645,455 (GRCm39)	D234G	probably damaging	Het
Fat3	A	C	9: 16,289,197 (GRCm39)	S109A	probably benign	Het
Fras1	G	T	5: 96,735,990 (GRCm39)	M528I	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gtf3c1	A	G	7: 125,261,548 (GRCm39)	F1189L	probably benign	Het
Ift81	A	T	5: 122,740,739 (GRCm39)		probably benign	Het
Insyn2b	A	G	11: 34,353,065 (GRCm39)	E369G	probably benign	Het
Lag3	A	G	6: 124,887,869 (GRCm39)	S22P	probably benign	Het
Mtx2	T	A	2: 74,706,733 (GRCm39)	V236E	probably damaging	Het
Naip6	T	C	13: 100,436,820 (GRCm39)	T568A	probably benign	Het
Or5k8	A	G	16: 58,644,337 (GRCm39)	F245S	probably damaging	Het
Or6c35	T	A	10: 129,169,232 (GRCm39)	L161M	probably damaging	Het
Or6c68	T	C	10: 129,157,585 (GRCm39)	I31T	probably benign	Het
Or6c88	G	A	10: 129,406,696 (GRCm39)	M57I	possibly damaging	Het
Or8b53	A	C	9: 38,667,194 (GRCm39)	D70A	probably damaging	Het
Pcid2	A	G	8: 13,128,243 (GRCm39)	V386A	probably benign	Het
Pde8b	T	C	13: 95,237,446 (GRCm39)	D116G	probably damaging	Het
Plxnc1	A	G	10: 94,634,008 (GRCm39)	V1365A	possibly damaging	Het
Prex2	G	T	1: 11,168,727 (GRCm39)	C241F	probably benign	Het
Prr23a2	A	G	9: 98,739,113 (GRCm39)	E157G	probably benign	Het
Ptpn4	A	T	1: 119,603,329 (GRCm39)	H836Q	probably benign	Het
Ptprd	C	T	4: 76,161,884 (GRCm39)	R117H	probably damaging	Het
Rab11fip4	T	C	11: 79,574,216 (GRCm39)	S102P	probably benign	Het
Slc44a1	G	T	4: 53,536,405 (GRCm39)	V194F	probably damaging	Het
Synm	T	A	7: 67,383,222 (GRCm39)	H1480L	probably benign	Het
Tmem63a	A	G	1: 180,783,570 (GRCm39)	Y175C	possibly damaging	Het
Trmt61a	C	T	12: 111,645,150 (GRCm39)	R29C	probably benign	Het
Ubap1	C	T	4: 41,379,236 (GRCm39)	T150I	probably benign	Het
Uimc1	T	C	13: 55,223,214 (GRCm39)	M353V	probably benign	Het
Usp34	T	C	11: 23,334,411 (GRCm39)	M1135T	possibly damaging	Het
Vmn1r25	A	C	6: 57,956,196 (GRCm39)	L31R	probably damaging	Het
Wtap	T	C	17: 13,188,342 (GRCm39)	E186G	probably benign	Het
Wwc2	T	G	8: 48,336,615 (GRCm39)	N216H	probably benign	Het
Zhx1	A	T	15: 57,917,841 (GRCm39)	M135K	probably damaging	Het

Other mutations in Mos

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00848:Mos	APN	4	3,871,459 (GRCm39)	missense	probably damaging	1.00
IGL01302:Mos	APN	4	3,871,815 (GRCm39)	utr 5 prime	probably benign
IGL01739:Mos	APN	4	3,871,816 (GRCm39)	utr 5 prime	probably benign
IGL02647:Mos	APN	4	3,870,961 (GRCm39)	missense	probably damaging	1.00
PIT4418001:Mos	UTSW	4	3,870,814 (GRCm39)	missense	possibly damaging	0.86
R0967:Mos	UTSW	4	3,870,932 (GRCm39)	missense	probably benign
R4927:Mos	UTSW	4	3,871,093 (GRCm39)	missense	probably damaging	1.00
R5729:Mos	UTSW	4	3,870,971 (GRCm39)	missense	probably benign	0.01
R6947:Mos	UTSW	4	3,871,585 (GRCm39)	missense	probably damaging	1.00
R8359:Mos	UTSW	4	3,871,097 (GRCm39)	missense	probably damaging	1.00
R8526:Mos	UTSW	4	3,871,709 (GRCm39)	missense	probably damaging	0.99
R9106:Mos	UTSW	4	3,871,457 (GRCm39)	missense	probably benign	0.44
R9336:Mos	UTSW	4	3,870,886 (GRCm39)	missense	probably damaging	1.00
R9347:Mos	UTSW	4	3,871,763 (GRCm39)	missense	probably benign	0.02
R9683:Mos	UTSW	4	3,871,186 (GRCm39)	missense	probably benign	0.02

Posted On

2014-05-07