Incidental Mutation 'IGL01868:Gm14548'
ID178598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm14548
Ensembl Gene ENSMUSG00000074417
Gene Namepredicted gene 14548
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.015) question?
Stock #IGL01868
Quality Score
Status
Chromosome7
Chromosomal Location3884242-3898120 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 3897175 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 143 (Q143*)
Ref Sequence ENSEMBL: ENSMUSP00000070073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070639]
Predicted Effect probably null
Transcript: ENSMUST00000070639
AA Change: Q143*
SMART Domains Protein: ENSMUSP00000070073
Gene: ENSMUSG00000074417
AA Change: Q143*

DomainStartEndE-ValueType
IG 34 118 6.41e-2 SMART
IG 129 315 8.59e-3 SMART
IG_like 237 302 1.91e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.11e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 627 636 N/A INTRINSIC
low complexity region 654 663 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 G A 18: 67,414,148 T569M possibly damaging Het
Aldh1l1 A T 6: 90,583,230 K620* probably null Het
Amdhd2 G T 17: 24,157,530 T346K probably damaging Het
Arhgap44 T C 11: 65,012,078 D521G probably damaging Het
Ccdc146 C A 5: 21,333,054 A91S probably damaging Het
Ccdc187 C A 2: 26,280,948 R506L probably benign Het
Cd37 T C 7: 45,236,179 Q128R probably benign Het
Cdh22 T A 2: 165,157,358 M185L probably damaging Het
Cib2 A T 9: 54,548,475 N68K probably damaging Het
Ddx46 C T 13: 55,639,870 R96* probably null Het
Dnajc13 A T 9: 104,162,745 H2050Q possibly damaging Het
Duox1 A G 2: 122,338,407 H1172R probably benign Het
Eftud2 C T 11: 102,869,127 V132I probably benign Het
Fcrl5 G A 3: 87,443,707 D87N possibly damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Kat6a T C 8: 22,926,455 F660L probably damaging Het
Lipo2 T C 19: 33,730,838 M259V probably benign Het
Lrrcc1 T A 3: 14,554,357 L90* probably null Het
Lsm1 G A 8: 25,793,793 probably null Het
Luzp1 T C 4: 136,542,737 I757T probably damaging Het
Micall1 A G 15: 79,115,060 I76V probably benign Het
Mmp21 A T 7: 133,675,914 D394E probably damaging Het
Mtfr1l T C 4: 134,530,707 D68G probably null Het
Necab2 A G 8: 119,462,576 S162G probably benign Het
Olfr1186 T C 2: 88,525,715 V44A possibly damaging Het
Olfr429 C T 1: 174,089,370 T110I possibly damaging Het
Olfr64 G A 7: 103,893,376 R120* probably null Het
Olfr96 A T 17: 37,225,152 Q9L probably benign Het
Pde7b A T 10: 20,407,165 C376* probably null Het
Plcb2 A G 2: 118,709,590 L1074P probably damaging Het
Plcb2 G T 2: 118,711,387 T914N probably benign Het
Prph C A 15: 99,056,343 D207E probably damaging Het
Prrxl1 C A 14: 32,608,377 F150L probably damaging Het
Rbp4 C A 19: 38,124,520 R37L probably damaging Het
Ryr3 T C 2: 112,803,158 probably benign Het
Sardh T G 2: 27,227,147 Q496P probably benign Het
Serpina1f T A 12: 103,693,445 N193Y probably benign Het
Slc10a7 G A 8: 78,697,336 probably null Het
Spg7 T C 8: 123,090,236 probably null Het
Sphkap T C 1: 83,280,399 probably null Het
Tas2r121 T A 6: 132,700,272 I246L probably benign Het
Tbc1d9b T C 11: 50,161,633 F889S probably damaging Het
Tcp10a T C 17: 7,329,864 M140T possibly damaging Het
Tctn2 G A 5: 124,616,528 noncoding transcript Het
Tfap2b G T 1: 19,214,282 R138L probably damaging Het
Tnrc18 T C 5: 142,771,812 T985A unknown Het
Treml1 G A 17: 48,366,007 V211I probably benign Het
Ubr4 C T 4: 139,412,678 Q1191* probably null Het
Vim G A 2: 13,578,438 R217H possibly damaging Het
Vmn2r77 A G 7: 86,803,016 D468G probably benign Het
Vmn2r98 G T 17: 19,066,286 V349F probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Vwa7 A T 17: 35,021,259 E401V probably null Het
Zfp119b C A 17: 55,939,866 V75L possibly damaging Het
Zfp287 C T 11: 62,715,257 E275K probably benign Het
Other mutations in Gm14548
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00541:Gm14548 APN 7 3897386 splice site probably benign
IGL01358:Gm14548 APN 7 3895687 missense probably benign 0.41
IGL02421:Gm14548 APN 7 3896995 missense possibly damaging 0.87
IGL02544:Gm14548 APN 7 3897186 missense probably damaging 0.96
IGL02960:Gm14548 APN 7 3897079 missense possibly damaging 0.88
IGL02973:Gm14548 APN 7 3897240 missense probably damaging 1.00
R0761:Gm14548 UTSW 7 3893979 critical splice donor site probably null
R1917:Gm14548 UTSW 7 3897638 missense probably damaging 1.00
R1920:Gm14548 UTSW 7 3897872 missense probably damaging 0.98
R2219:Gm14548 UTSW 7 3897489 missense probably benign 0.10
R2220:Gm14548 UTSW 7 3897489 missense probably benign 0.10
R4991:Gm14548 UTSW 7 3895572 missense probably benign 0.37
R5271:Gm14548 UTSW 7 3897567 nonsense probably null
R5909:Gm14548 UTSW 7 3897622 missense probably damaging 1.00
R6008:Gm14548 UTSW 7 3894600 missense probably damaging 1.00
R6193:Gm14548 UTSW 7 3898050 critical splice donor site probably null
R6218:Gm14548 UTSW 7 3894032 missense possibly damaging 0.65
R6219:Gm14548 UTSW 7 3894641 missense probably damaging 1.00
R6650:Gm14548 UTSW 7 3895633 missense probably benign 0.15
R6879:Gm14548 UTSW 7 3896962 missense probably benign 0.40
R6987:Gm14548 UTSW 7 3897661 missense probably damaging 0.99
R7082:Gm14548 UTSW 7 3895511 missense not run
R7087:Gm14548 UTSW 7 3897219 missense not run
R7144:Gm14548 UTSW 7 3897616 missense not run
Posted On2014-05-07