Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01868:Or51b17'

178603

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or51b17

Ensembl Gene

ENSMUSG00000063615

Gene Name

olfactory receptor family 51 subfamily B member 17

Synonyms

GA_x6K02T2PBJ9-6648196-6649143, Olfr64, 5'[b]2, MOR1-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.205) question?

Stock #

IGL01868

Quality Score

Status

Chromosome

Chromosomal Location

103542017-103543678 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 103542583 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 120 (R120*)

Ref Sequence

ENSEMBL: ENSMUSP00000080444 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081748]

AlphaFold

F8VPZ8

Predicted Effect

probably null
Transcript: ENSMUST00000081748
AA Change: R120*

SMART Domains

Protein: ENSMUSP00000080444
Gene: ENSMUSG00000063615
AA Change: R120*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	2.4e-113	PFAM
Pfam:7TM_GPCR_Srsx	33	295	4.2e-6	PFAM
Pfam:7tm_1	39	290	1.1e-22	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	G	A	18: 67,547,218 (GRCm39)	T569M	possibly damaging	Het
Aldh1l1	A	T	6: 90,560,212 (GRCm39)	K620*	probably null	Het
Amdhd2	G	T	17: 24,376,504 (GRCm39)	T346K	probably damaging	Het
Arhgap44	T	C	11: 64,902,904 (GRCm39)	D521G	probably damaging	Het
Ccdc146	C	A	5: 21,538,052 (GRCm39)	A91S	probably damaging	Het
Ccdc187	C	A	2: 26,170,960 (GRCm39)	R506L	probably benign	Het
Cd37	T	C	7: 44,885,603 (GRCm39)	Q128R	probably benign	Het
Cdh22	T	A	2: 164,999,278 (GRCm39)	M185L	probably damaging	Het
Cib2	A	T	9: 54,455,759 (GRCm39)	N68K	probably damaging	Het
Ddx46	C	T	13: 55,787,683 (GRCm39)	R96*	probably null	Het
Dnajc13	A	T	9: 104,039,944 (GRCm39)	H2050Q	possibly damaging	Het
Drgx	C	A	14: 32,330,334 (GRCm39)	F150L	probably damaging	Het
Duox1	A	G	2: 122,168,888 (GRCm39)	H1172R	probably benign	Het
Eftud2	C	T	11: 102,759,953 (GRCm39)	V132I	probably benign	Het
Fcrl5	G	A	3: 87,351,014 (GRCm39)	D87N	possibly damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Kat6a	T	C	8: 23,416,471 (GRCm39)	F660L	probably damaging	Het
Lipo2	T	C	19: 33,708,238 (GRCm39)	M259V	probably benign	Het
Lrrcc1	T	A	3: 14,619,417 (GRCm39)	L90*	probably null	Het
Lsm1	G	A	8: 26,283,821 (GRCm39)		probably null	Het
Luzp1	T	C	4: 136,270,048 (GRCm39)	I757T	probably damaging	Het
Micall1	A	G	15: 78,999,260 (GRCm39)	I76V	probably benign	Het
Mmp21	A	T	7: 133,277,643 (GRCm39)	D394E	probably damaging	Het
Mtfr1l	T	C	4: 134,258,018 (GRCm39)	D68G	probably null	Het
Necab2	A	G	8: 120,189,315 (GRCm39)	S162G	probably benign	Het
Or11a4	A	T	17: 37,536,043 (GRCm39)	Q9L	probably benign	Het
Or4c100	T	C	2: 88,356,059 (GRCm39)	V44A	possibly damaging	Het
Or6n1	C	T	1: 173,916,936 (GRCm39)	T110I	possibly damaging	Het
Pde7b	A	T	10: 20,282,911 (GRCm39)	C376*	probably null	Het
Pira12	G	A	7: 3,900,174 (GRCm39)	Q143*	probably null	Het
Plcb2	A	G	2: 118,540,071 (GRCm39)	L1074P	probably damaging	Het
Plcb2	G	T	2: 118,541,868 (GRCm39)	T914N	probably benign	Het
Prph	C	A	15: 98,954,224 (GRCm39)	D207E	probably damaging	Het
Rbp4	C	A	19: 38,112,968 (GRCm39)	R37L	probably damaging	Het
Ryr3	T	C	2: 112,633,503 (GRCm39)		probably benign	Het
Sardh	T	G	2: 27,117,159 (GRCm39)	Q496P	probably benign	Het
Serpina1f	T	A	12: 103,659,704 (GRCm39)	N193Y	probably benign	Het
Slc10a7	G	A	8: 79,423,965 (GRCm39)		probably null	Het
Spg7	T	C	8: 123,816,975 (GRCm39)		probably null	Het
Sphkap	T	C	1: 83,258,120 (GRCm39)		probably null	Het
Tas2r121	T	A	6: 132,677,235 (GRCm39)	I246L	probably benign	Het
Tbc1d9b	T	C	11: 50,052,460 (GRCm39)	F889S	probably damaging	Het
Tcp10a	T	C	17: 7,597,263 (GRCm39)	M140T	possibly damaging	Het
Tctn2	G	A	5: 124,754,591 (GRCm39)		noncoding transcript	Het
Tfap2b	G	T	1: 19,284,506 (GRCm39)	R138L	probably damaging	Het
Tnrc18	T	C	5: 142,757,567 (GRCm39)	T985A	unknown	Het
Treml1	G	A	17: 48,673,035 (GRCm39)	V211I	probably benign	Het
Ubr4	C	T	4: 139,139,989 (GRCm39)	Q1191*	probably null	Het
Vim	G	A	2: 13,583,249 (GRCm39)	R217H	possibly damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r77	A	G	7: 86,452,224 (GRCm39)	D468G	probably benign	Het
Vmn2r98	G	T	17: 19,286,548 (GRCm39)	V349F	probably benign	Het
Vwa7	A	T	17: 35,240,235 (GRCm39)	E401V	probably null	Het
Zfp119b	C	A	17: 56,246,866 (GRCm39)	V75L	possibly damaging	Het
Zfp287	C	T	11: 62,606,083 (GRCm39)	E275K	probably benign	Het

Other mutations in Or51b17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00934:Or51b17	APN	7	103,542,071 (GRCm39)	nonsense	probably null
IGL01597:Or51b17	APN	7	103,542,303 (GRCm39)	missense	probably benign	0.01
IGL02502:Or51b17	APN	7	103,542,696 (GRCm39)	missense	probably damaging	0.99
R0294:Or51b17	UTSW	7	103,542,137 (GRCm39)	missense	probably benign	0.09
R0534:Or51b17	UTSW	7	103,542,438 (GRCm39)	missense	probably benign	0.00
R0838:Or51b17	UTSW	7	103,542,622 (GRCm39)	missense	probably benign	0.00
R1350:Or51b17	UTSW	7	103,542,937 (GRCm39)	missense	probably benign	0.01
R1733:Or51b17	UTSW	7	103,542,118 (GRCm39)	missense	probably benign	0.40
R1768:Or51b17	UTSW	7	103,542,484 (GRCm39)	missense	probably benign	0.28
R1780:Or51b17	UTSW	7	103,542,762 (GRCm39)	missense	probably damaging	1.00
R1836:Or51b17	UTSW	7	103,542,592 (GRCm39)	missense	probably damaging	0.98
R1956:Or51b17	UTSW	7	103,542,925 (GRCm39)	missense	probably benign	0.01
R2075:Or51b17	UTSW	7	103,542,127 (GRCm39)	missense	probably damaging	0.96
R4677:Or51b17	UTSW	7	103,542,615 (GRCm39)	missense	probably damaging	1.00
R4884:Or51b17	UTSW	7	103,542,862 (GRCm39)	missense	probably benign	0.04
R4899:Or51b17	UTSW	7	103,542,672 (GRCm39)	missense	possibly damaging	0.54
R5753:Or51b17	UTSW	7	103,542,408 (GRCm39)	missense	probably damaging	1.00
R6351:Or51b17	UTSW	7	103,542,342 (GRCm39)	nonsense	probably null
R6997:Or51b17	UTSW	7	103,542,238 (GRCm39)	missense	probably benign	0.00
R8319:Or51b17	UTSW	7	103,542,636 (GRCm39)	missense	probably damaging	1.00
R8337:Or51b17	UTSW	7	103,542,256 (GRCm39)	missense	probably benign
R8984:Or51b17	UTSW	7	103,542,816 (GRCm39)	missense	probably benign	0.01
R9780:Or51b17	UTSW	7	103,542,631 (GRCm39)	missense	probably damaging	0.99
X0017:Or51b17	UTSW	7	103,542,358 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07