Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01868:Tas2r121'

178626

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r121

Ensembl Gene

ENSMUSG00000071150

Gene Name

taste receptor, type 2, member 121

Synonyms

mGR21, T2R21, Tas2r21, mT2r48

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL01868

Quality Score

Status

Chromosome

Chromosomal Location

132677053-132677970 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132677235 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 246 (I246L)

Ref Sequence

ENSEMBL: ENSMUSP00000093044 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095395]

AlphaFold

Q7M720

Predicted Effect

probably benign
Transcript: ENSMUST00000095395
AA Change: I246L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000093044
Gene: ENSMUSG00000071150
AA Change: I246L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	300	4.5e-108	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	G	A	18: 67,547,218 (GRCm39)	T569M	possibly damaging	Het
Aldh1l1	A	T	6: 90,560,212 (GRCm39)	K620*	probably null	Het
Amdhd2	G	T	17: 24,376,504 (GRCm39)	T346K	probably damaging	Het
Arhgap44	T	C	11: 64,902,904 (GRCm39)	D521G	probably damaging	Het
Ccdc146	C	A	5: 21,538,052 (GRCm39)	A91S	probably damaging	Het
Ccdc187	C	A	2: 26,170,960 (GRCm39)	R506L	probably benign	Het
Cd37	T	C	7: 44,885,603 (GRCm39)	Q128R	probably benign	Het
Cdh22	T	A	2: 164,999,278 (GRCm39)	M185L	probably damaging	Het
Cib2	A	T	9: 54,455,759 (GRCm39)	N68K	probably damaging	Het
Ddx46	C	T	13: 55,787,683 (GRCm39)	R96*	probably null	Het
Dnajc13	A	T	9: 104,039,944 (GRCm39)	H2050Q	possibly damaging	Het
Drgx	C	A	14: 32,330,334 (GRCm39)	F150L	probably damaging	Het
Duox1	A	G	2: 122,168,888 (GRCm39)	H1172R	probably benign	Het
Eftud2	C	T	11: 102,759,953 (GRCm39)	V132I	probably benign	Het
Fcrl5	G	A	3: 87,351,014 (GRCm39)	D87N	possibly damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Kat6a	T	C	8: 23,416,471 (GRCm39)	F660L	probably damaging	Het
Lipo2	T	C	19: 33,708,238 (GRCm39)	M259V	probably benign	Het
Lrrcc1	T	A	3: 14,619,417 (GRCm39)	L90*	probably null	Het
Lsm1	G	A	8: 26,283,821 (GRCm39)		probably null	Het
Luzp1	T	C	4: 136,270,048 (GRCm39)	I757T	probably damaging	Het
Micall1	A	G	15: 78,999,260 (GRCm39)	I76V	probably benign	Het
Mmp21	A	T	7: 133,277,643 (GRCm39)	D394E	probably damaging	Het
Mtfr1l	T	C	4: 134,258,018 (GRCm39)	D68G	probably null	Het
Necab2	A	G	8: 120,189,315 (GRCm39)	S162G	probably benign	Het
Or11a4	A	T	17: 37,536,043 (GRCm39)	Q9L	probably benign	Het
Or4c100	T	C	2: 88,356,059 (GRCm39)	V44A	possibly damaging	Het
Or51b17	G	A	7: 103,542,583 (GRCm39)	R120*	probably null	Het
Or6n1	C	T	1: 173,916,936 (GRCm39)	T110I	possibly damaging	Het
Pde7b	A	T	10: 20,282,911 (GRCm39)	C376*	probably null	Het
Pira12	G	A	7: 3,900,174 (GRCm39)	Q143*	probably null	Het
Plcb2	A	G	2: 118,540,071 (GRCm39)	L1074P	probably damaging	Het
Plcb2	G	T	2: 118,541,868 (GRCm39)	T914N	probably benign	Het
Prph	C	A	15: 98,954,224 (GRCm39)	D207E	probably damaging	Het
Rbp4	C	A	19: 38,112,968 (GRCm39)	R37L	probably damaging	Het
Ryr3	T	C	2: 112,633,503 (GRCm39)		probably benign	Het
Sardh	T	G	2: 27,117,159 (GRCm39)	Q496P	probably benign	Het
Serpina1f	T	A	12: 103,659,704 (GRCm39)	N193Y	probably benign	Het
Slc10a7	G	A	8: 79,423,965 (GRCm39)		probably null	Het
Spg7	T	C	8: 123,816,975 (GRCm39)		probably null	Het
Sphkap	T	C	1: 83,258,120 (GRCm39)		probably null	Het
Tbc1d9b	T	C	11: 50,052,460 (GRCm39)	F889S	probably damaging	Het
Tcp10a	T	C	17: 7,597,263 (GRCm39)	M140T	possibly damaging	Het
Tctn2	G	A	5: 124,754,591 (GRCm39)		noncoding transcript	Het
Tfap2b	G	T	1: 19,284,506 (GRCm39)	R138L	probably damaging	Het
Tnrc18	T	C	5: 142,757,567 (GRCm39)	T985A	unknown	Het
Treml1	G	A	17: 48,673,035 (GRCm39)	V211I	probably benign	Het
Ubr4	C	T	4: 139,139,989 (GRCm39)	Q1191*	probably null	Het
Vim	G	A	2: 13,583,249 (GRCm39)	R217H	possibly damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r77	A	G	7: 86,452,224 (GRCm39)	D468G	probably benign	Het
Vmn2r98	G	T	17: 19,286,548 (GRCm39)	V349F	probably benign	Het
Vwa7	A	T	17: 35,240,235 (GRCm39)	E401V	probably null	Het
Zfp119b	C	A	17: 56,246,866 (GRCm39)	V75L	possibly damaging	Het
Zfp287	C	T	11: 62,606,083 (GRCm39)	E275K	probably benign	Het

Other mutations in Tas2r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00559:Tas2r121	APN	6	132,677,484 (GRCm39)	missense	probably benign	0.28
IGL02182:Tas2r121	APN	6	132,677,133 (GRCm39)	missense	probably damaging	0.99
IGL02728:Tas2r121	APN	6	132,677,480 (GRCm39)	missense	probably damaging	1.00
R0833:Tas2r121	UTSW	6	132,677,325 (GRCm39)	missense	probably damaging	1.00
R0836:Tas2r121	UTSW	6	132,677,325 (GRCm39)	missense	probably damaging	1.00
R1181:Tas2r121	UTSW	6	132,677,132 (GRCm39)	missense	probably damaging	1.00
R1424:Tas2r121	UTSW	6	132,677,645 (GRCm39)	missense	probably damaging	1.00
R1583:Tas2r121	UTSW	6	132,677,193 (GRCm39)	nonsense	probably null
R2179:Tas2r121	UTSW	6	132,677,831 (GRCm39)	missense	probably damaging	1.00
R4711:Tas2r121	UTSW	6	132,677,853 (GRCm39)	missense	probably benign	0.28
R5274:Tas2r121	UTSW	6	132,677,811 (GRCm39)	missense	probably damaging	1.00
R5308:Tas2r121	UTSW	6	132,677,480 (GRCm39)	missense	possibly damaging	0.84
R5663:Tas2r121	UTSW	6	132,677,520 (GRCm39)	missense	probably benign	0.10
R5668:Tas2r121	UTSW	6	132,677,756 (GRCm39)	missense	possibly damaging	0.95
R5885:Tas2r121	UTSW	6	132,677,254 (GRCm39)	missense	probably damaging	1.00
R6395:Tas2r121	UTSW	6	132,677,495 (GRCm39)	missense	probably benign	0.23
R7552:Tas2r121	UTSW	6	132,677,505 (GRCm39)	missense	probably benign	0.17
R8094:Tas2r121	UTSW	6	132,677,772 (GRCm39)	missense	probably benign
R9192:Tas2r121	UTSW	6	132,677,492 (GRCm39)	missense	probably benign	0.00
R9718:Tas2r121	UTSW	6	132,677,765 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07