Incidental Mutation 'IGL01868:Or6n1'
ID 178628
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6n1
Ensembl Gene ENSMUSG00000049528
Gene Name olfactory receptor family 6 subfamily N member 1
Synonyms Olfr429, GA_x6K02T2P20D-21090094-21089156, MOR105-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # IGL01868
Quality Score
Status
Chromosome 1
Chromosomal Location 173916604-173917546 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 173916936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 110 (T110I)
Ref Sequence ENSEMBL: ENSMUSP00000149257 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060693] [ENSMUST00000216346]
AlphaFold Q7TRW1
Predicted Effect possibly damaging
Transcript: ENSMUST00000060693
AA Change: T110I

PolyPhen 2 Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000051323
Gene: ENSMUSG00000049528
AA Change: T110I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-65 PFAM
Pfam:7tm_1 41 290 1.3e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000193320
AA Change: T110I

PolyPhen 2 Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000142323
Gene: ENSMUSG00000049528
AA Change: T110I

DomainStartEndE-ValueType
low complexity region 25 40 N/A INTRINSIC
Pfam:7tm_1 41 290 8.9e-31 PFAM
Pfam:7tm_4 139 283 6.7e-43 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216346
AA Change: T110I

PolyPhen 2 Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 G A 18: 67,547,218 (GRCm39) T569M possibly damaging Het
Aldh1l1 A T 6: 90,560,212 (GRCm39) K620* probably null Het
Amdhd2 G T 17: 24,376,504 (GRCm39) T346K probably damaging Het
Arhgap44 T C 11: 64,902,904 (GRCm39) D521G probably damaging Het
Ccdc146 C A 5: 21,538,052 (GRCm39) A91S probably damaging Het
Ccdc187 C A 2: 26,170,960 (GRCm39) R506L probably benign Het
Cd37 T C 7: 44,885,603 (GRCm39) Q128R probably benign Het
Cdh22 T A 2: 164,999,278 (GRCm39) M185L probably damaging Het
Cib2 A T 9: 54,455,759 (GRCm39) N68K probably damaging Het
Ddx46 C T 13: 55,787,683 (GRCm39) R96* probably null Het
Dnajc13 A T 9: 104,039,944 (GRCm39) H2050Q possibly damaging Het
Drgx C A 14: 32,330,334 (GRCm39) F150L probably damaging Het
Duox1 A G 2: 122,168,888 (GRCm39) H1172R probably benign Het
Eftud2 C T 11: 102,759,953 (GRCm39) V132I probably benign Het
Fcrl5 G A 3: 87,351,014 (GRCm39) D87N possibly damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Kat6a T C 8: 23,416,471 (GRCm39) F660L probably damaging Het
Lipo2 T C 19: 33,708,238 (GRCm39) M259V probably benign Het
Lrrcc1 T A 3: 14,619,417 (GRCm39) L90* probably null Het
Lsm1 G A 8: 26,283,821 (GRCm39) probably null Het
Luzp1 T C 4: 136,270,048 (GRCm39) I757T probably damaging Het
Micall1 A G 15: 78,999,260 (GRCm39) I76V probably benign Het
Mmp21 A T 7: 133,277,643 (GRCm39) D394E probably damaging Het
Mtfr1l T C 4: 134,258,018 (GRCm39) D68G probably null Het
Necab2 A G 8: 120,189,315 (GRCm39) S162G probably benign Het
Or11a4 A T 17: 37,536,043 (GRCm39) Q9L probably benign Het
Or4c100 T C 2: 88,356,059 (GRCm39) V44A possibly damaging Het
Or51b17 G A 7: 103,542,583 (GRCm39) R120* probably null Het
Pde7b A T 10: 20,282,911 (GRCm39) C376* probably null Het
Pira12 G A 7: 3,900,174 (GRCm39) Q143* probably null Het
Plcb2 A G 2: 118,540,071 (GRCm39) L1074P probably damaging Het
Plcb2 G T 2: 118,541,868 (GRCm39) T914N probably benign Het
Prph C A 15: 98,954,224 (GRCm39) D207E probably damaging Het
Rbp4 C A 19: 38,112,968 (GRCm39) R37L probably damaging Het
Ryr3 T C 2: 112,633,503 (GRCm39) probably benign Het
Sardh T G 2: 27,117,159 (GRCm39) Q496P probably benign Het
Serpina1f T A 12: 103,659,704 (GRCm39) N193Y probably benign Het
Slc10a7 G A 8: 79,423,965 (GRCm39) probably null Het
Spg7 T C 8: 123,816,975 (GRCm39) probably null Het
Sphkap T C 1: 83,258,120 (GRCm39) probably null Het
Tas2r121 T A 6: 132,677,235 (GRCm39) I246L probably benign Het
Tbc1d9b T C 11: 50,052,460 (GRCm39) F889S probably damaging Het
Tcp10a T C 17: 7,597,263 (GRCm39) M140T possibly damaging Het
Tctn2 G A 5: 124,754,591 (GRCm39) noncoding transcript Het
Tfap2b G T 1: 19,284,506 (GRCm39) R138L probably damaging Het
Tnrc18 T C 5: 142,757,567 (GRCm39) T985A unknown Het
Treml1 G A 17: 48,673,035 (GRCm39) V211I probably benign Het
Ubr4 C T 4: 139,139,989 (GRCm39) Q1191* probably null Het
Vim G A 2: 13,583,249 (GRCm39) R217H possibly damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r77 A G 7: 86,452,224 (GRCm39) D468G probably benign Het
Vmn2r98 G T 17: 19,286,548 (GRCm39) V349F probably benign Het
Vwa7 A T 17: 35,240,235 (GRCm39) E401V probably null Het
Zfp119b C A 17: 56,246,866 (GRCm39) V75L possibly damaging Het
Zfp287 C T 11: 62,606,083 (GRCm39) E275K probably benign Het
Other mutations in Or6n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Or6n1 APN 1 173,917,122 (GRCm39) missense probably damaging 1.00
IGL01972:Or6n1 APN 1 173,916,987 (GRCm39) missense probably damaging 0.99
IGL02412:Or6n1 APN 1 173,916,809 (GRCm39) missense probably benign 0.00
IGL02628:Or6n1 APN 1 173,916,756 (GRCm39) missense probably benign
IGL02861:Or6n1 APN 1 173,916,602 (GRCm39) utr 5 prime probably benign
IGL03404:Or6n1 APN 1 173,917,464 (GRCm39) missense probably damaging 1.00
R0267:Or6n1 UTSW 1 173,916,732 (GRCm39) missense probably damaging 1.00
R0357:Or6n1 UTSW 1 173,916,675 (GRCm39) missense possibly damaging 0.71
R1499:Or6n1 UTSW 1 173,916,813 (GRCm39) nonsense probably null
R2051:Or6n1 UTSW 1 173,916,785 (GRCm39) missense possibly damaging 0.95
R4706:Or6n1 UTSW 1 173,917,268 (GRCm39) missense probably damaging 1.00
R4820:Or6n1 UTSW 1 173,916,742 (GRCm39) missense possibly damaging 0.95
R5439:Or6n1 UTSW 1 173,917,541 (GRCm39) missense probably benign 0.01
R5538:Or6n1 UTSW 1 173,917,544 (GRCm39) makesense probably null
R5907:Or6n1 UTSW 1 173,916,785 (GRCm39) missense probably benign 0.08
R6932:Or6n1 UTSW 1 173,917,316 (GRCm39) missense probably damaging 0.96
R7808:Or6n1 UTSW 1 173,917,417 (GRCm39) nonsense probably null
R8040:Or6n1 UTSW 1 173,916,723 (GRCm39) missense possibly damaging 0.68
R8467:Or6n1 UTSW 1 173,917,007 (GRCm39) missense probably benign 0.00
R9124:Or6n1 UTSW 1 173,917,341 (GRCm39) missense probably damaging 1.00
R9797:Or6n1 UTSW 1 173,917,356 (GRCm39) missense possibly damaging 0.65
Posted On 2014-05-07