Incidental Mutation 'IGL01868:Lipo2'
ID 178630
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lipo2
Ensembl Gene ENSMUSG00000087303
Gene Name lipase, member O2
Synonyms Gm8981
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL01868
Quality Score
Status
Chromosome 19
Chromosomal Location 33697070-33728759 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33708238 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 259 (M259V)
Ref Sequence ENSEMBL: ENSMUSP00000118907 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025694] [ENSMUST00000147153]
AlphaFold D3YY49
Predicted Effect probably benign
Transcript: ENSMUST00000025694
SMART Domains Protein: ENSMUSP00000025694
Gene: ENSMUSG00000024766

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 4.2e-24 PFAM
Pfam:Abhydrolase_1 76 213 7.3e-16 PFAM
Pfam:Abhydrolase_5 76 370 4.8e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147153
AA Change: M259V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000118907
Gene: ENSMUSG00000087303
AA Change: M259V

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 4.4e-24 PFAM
Pfam:Abhydrolase_1 76 213 1.7e-15 PFAM
Pfam:Abhydrolase_5 76 370 1.5e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 G A 18: 67,547,218 (GRCm39) T569M possibly damaging Het
Aldh1l1 A T 6: 90,560,212 (GRCm39) K620* probably null Het
Amdhd2 G T 17: 24,376,504 (GRCm39) T346K probably damaging Het
Arhgap44 T C 11: 64,902,904 (GRCm39) D521G probably damaging Het
Ccdc146 C A 5: 21,538,052 (GRCm39) A91S probably damaging Het
Ccdc187 C A 2: 26,170,960 (GRCm39) R506L probably benign Het
Cd37 T C 7: 44,885,603 (GRCm39) Q128R probably benign Het
Cdh22 T A 2: 164,999,278 (GRCm39) M185L probably damaging Het
Cib2 A T 9: 54,455,759 (GRCm39) N68K probably damaging Het
Ddx46 C T 13: 55,787,683 (GRCm39) R96* probably null Het
Dnajc13 A T 9: 104,039,944 (GRCm39) H2050Q possibly damaging Het
Drgx C A 14: 32,330,334 (GRCm39) F150L probably damaging Het
Duox1 A G 2: 122,168,888 (GRCm39) H1172R probably benign Het
Eftud2 C T 11: 102,759,953 (GRCm39) V132I probably benign Het
Fcrl5 G A 3: 87,351,014 (GRCm39) D87N possibly damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Kat6a T C 8: 23,416,471 (GRCm39) F660L probably damaging Het
Lrrcc1 T A 3: 14,619,417 (GRCm39) L90* probably null Het
Lsm1 G A 8: 26,283,821 (GRCm39) probably null Het
Luzp1 T C 4: 136,270,048 (GRCm39) I757T probably damaging Het
Micall1 A G 15: 78,999,260 (GRCm39) I76V probably benign Het
Mmp21 A T 7: 133,277,643 (GRCm39) D394E probably damaging Het
Mtfr1l T C 4: 134,258,018 (GRCm39) D68G probably null Het
Necab2 A G 8: 120,189,315 (GRCm39) S162G probably benign Het
Or11a4 A T 17: 37,536,043 (GRCm39) Q9L probably benign Het
Or4c100 T C 2: 88,356,059 (GRCm39) V44A possibly damaging Het
Or51b17 G A 7: 103,542,583 (GRCm39) R120* probably null Het
Or6n1 C T 1: 173,916,936 (GRCm39) T110I possibly damaging Het
Pde7b A T 10: 20,282,911 (GRCm39) C376* probably null Het
Pira12 G A 7: 3,900,174 (GRCm39) Q143* probably null Het
Plcb2 A G 2: 118,540,071 (GRCm39) L1074P probably damaging Het
Plcb2 G T 2: 118,541,868 (GRCm39) T914N probably benign Het
Prph C A 15: 98,954,224 (GRCm39) D207E probably damaging Het
Rbp4 C A 19: 38,112,968 (GRCm39) R37L probably damaging Het
Ryr3 T C 2: 112,633,503 (GRCm39) probably benign Het
Sardh T G 2: 27,117,159 (GRCm39) Q496P probably benign Het
Serpina1f T A 12: 103,659,704 (GRCm39) N193Y probably benign Het
Slc10a7 G A 8: 79,423,965 (GRCm39) probably null Het
Spg7 T C 8: 123,816,975 (GRCm39) probably null Het
Sphkap T C 1: 83,258,120 (GRCm39) probably null Het
Tas2r121 T A 6: 132,677,235 (GRCm39) I246L probably benign Het
Tbc1d9b T C 11: 50,052,460 (GRCm39) F889S probably damaging Het
Tcp10a T C 17: 7,597,263 (GRCm39) M140T possibly damaging Het
Tctn2 G A 5: 124,754,591 (GRCm39) noncoding transcript Het
Tfap2b G T 1: 19,284,506 (GRCm39) R138L probably damaging Het
Tnrc18 T C 5: 142,757,567 (GRCm39) T985A unknown Het
Treml1 G A 17: 48,673,035 (GRCm39) V211I probably benign Het
Ubr4 C T 4: 139,139,989 (GRCm39) Q1191* probably null Het
Vim G A 2: 13,583,249 (GRCm39) R217H possibly damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r77 A G 7: 86,452,224 (GRCm39) D468G probably benign Het
Vmn2r98 G T 17: 19,286,548 (GRCm39) V349F probably benign Het
Vwa7 A T 17: 35,240,235 (GRCm39) E401V probably null Het
Zfp119b C A 17: 56,246,866 (GRCm39) V75L possibly damaging Het
Zfp287 C T 11: 62,606,083 (GRCm39) E275K probably benign Het
Other mutations in Lipo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01564:Lipo2 APN 19 33,698,424 (GRCm39) missense probably benign 0.03
IGL01780:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL02291:Lipo2 APN 19 33,723,192 (GRCm39) missense possibly damaging 0.80
IGL02350:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL02357:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL02560:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL03354:Lipo2 APN 19 33,708,270 (GRCm39) missense probably benign 0.09
R0183:Lipo2 UTSW 19 33,726,951 (GRCm39) splice site probably null
R0529:Lipo2 UTSW 19 33,724,335 (GRCm39) missense probably benign 0.05
R0576:Lipo2 UTSW 19 33,726,824 (GRCm39) missense probably benign 0.02
R0579:Lipo2 UTSW 19 33,724,298 (GRCm39) missense probably damaging 0.99
R0594:Lipo2 UTSW 19 33,724,302 (GRCm39) missense possibly damaging 0.95
R0621:Lipo2 UTSW 19 33,708,339 (GRCm39) missense probably damaging 1.00
R1019:Lipo2 UTSW 19 33,708,257 (GRCm39) nonsense probably null
R2190:Lipo2 UTSW 19 33,725,969 (GRCm39) missense probably damaging 1.00
R2413:Lipo2 UTSW 19 33,728,657 (GRCm39) missense probably damaging 0.98
R4066:Lipo2 UTSW 19 33,698,259 (GRCm39) missense probably benign 0.01
R4258:Lipo2 UTSW 19 33,708,328 (GRCm39) missense possibly damaging 0.88
R4365:Lipo2 UTSW 19 33,699,108 (GRCm39) missense probably damaging 1.00
R4491:Lipo2 UTSW 19 33,699,100 (GRCm39) missense probably damaging 0.99
R4640:Lipo2 UTSW 19 33,698,237 (GRCm39) missense probably benign 0.04
R4822:Lipo2 UTSW 19 33,723,151 (GRCm39) missense probably benign 0.01
R4872:Lipo2 UTSW 19 33,726,914 (GRCm39) missense probably benign 0.00
R5004:Lipo2 UTSW 19 33,699,076 (GRCm39) critical splice donor site probably null
R5112:Lipo2 UTSW 19 33,725,865 (GRCm39) missense probably benign 0.00
R5440:Lipo2 UTSW 19 33,698,258 (GRCm39) missense probably benign 0.39
R5737:Lipo2 UTSW 19 33,699,096 (GRCm39) missense probably damaging 1.00
R6209:Lipo2 UTSW 19 33,726,852 (GRCm39) missense probably damaging 1.00
R6868:Lipo2 UTSW 19 33,725,862 (GRCm39) missense possibly damaging 0.86
R6893:Lipo2 UTSW 19 33,698,407 (GRCm39) nonsense probably null
R7176:Lipo2 UTSW 19 33,723,207 (GRCm39) missense possibly damaging 0.71
R7853:Lipo2 UTSW 19 33,737,344 (GRCm39) start gained probably benign
R8092:Lipo2 UTSW 19 33,726,880 (GRCm39) missense probably benign 0.00
R8101:Lipo2 UTSW 19 33,698,394 (GRCm39) missense possibly damaging 0.79
R8464:Lipo2 UTSW 19 33,726,023 (GRCm39) missense probably benign 0.02
R8958:Lipo2 UTSW 19 33,698,361 (GRCm39) nonsense probably null
R8968:Lipo2 UTSW 19 33,726,917 (GRCm39) missense probably damaging 1.00
R9752:Lipo2 UTSW 19 33,723,221 (GRCm39) missense possibly damaging 0.78
X0052:Lipo2 UTSW 19 33,698,345 (GRCm39) missense probably damaging 1.00
Z1088:Lipo2 UTSW 19 33,699,085 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07