Incidental Mutation 'IGL01869:Olfr266'
ID178646
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr266
Ensembl Gene ENSMUSG00000043529
Gene Nameolfactory receptor 266
SynonymsMOR122-2, GA_x6K02T2N6GK-529983-529033
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01869
Quality Score
Status
Chromosome3
Chromosomal Location106820485-106826287 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 106822026 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Asparagine at position 178 (D178N)
Ref Sequence ENSEMBL: ENSMUSP00000150519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059486] [ENSMUST00000213616] [ENSMUST00000216610]
Predicted Effect probably benign
Transcript: ENSMUST00000059486
AA Change: D178N

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000054070
Gene: ENSMUSG00000043529
AA Change: D178N

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-58 PFAM
Pfam:7tm_1 44 293 5.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213616
AA Change: D178N

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000216610
AA Change: D178N

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700026F02Rik A G 8: 71,043,045 noncoding transcript Het
Adam29 T C 8: 55,871,697 H574R probably damaging Het
Arap1 C A 7: 101,400,283 T984K probably damaging Het
Ccdc146 A T 5: 21,316,839 S396T probably benign Het
Col6a3 T C 1: 90,773,048 K2587E unknown Het
Cyp3a44 A G 5: 145,790,686 S278P probably damaging Het
Daw1 T G 1: 83,182,244 probably benign Het
Dnah17 T C 11: 118,052,676 K3200R probably benign Het
Efhd2 A G 4: 141,874,602 F89S probably damaging Het
Fras1 A G 5: 96,708,783 probably benign Het
Ggps1 T C 13: 14,054,394 D68G probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm3604 A T 13: 62,370,140 C134S probably damaging Het
Gpaa1 A G 15: 76,332,998 T178A probably benign Het
Lama3 A G 18: 12,524,763 N312S possibly damaging Het
Npepps T C 11: 97,236,122 I437M probably damaging Het
Olfr1495 A G 19: 13,769,170 D276G probably benign Het
Rcor1 C A 12: 111,103,759 T330K possibly damaging Het
Sbno2 A G 10: 80,060,392 probably null Het
Sema3g A G 14: 31,223,667 E478G probably damaging Het
Smg9 A G 7: 24,416,524 D280G probably damaging Het
Smtnl1 A T 2: 84,811,397 *460R probably null Het
Syde1 A G 10: 78,588,919 C360R possibly damaging Het
Szt2 A G 4: 118,399,071 V197A possibly damaging Het
Tnrc6c T C 11: 117,755,448 V1405A possibly damaging Het
Ttbk1 A G 17: 46,447,063 S882P probably damaging Het
Tubgcp4 T A 2: 121,175,788 H116Q possibly damaging Het
Vmn1r192 T A 13: 22,187,580 N157Y probably damaging Het
Vmn1r60 C T 7: 5,544,229 V291M probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Xpo5 C T 17: 46,242,207 P1184L possibly damaging Het
Zfp946 T G 17: 22,454,703 I146S probably benign Het
Other mutations in Olfr266
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01954:Olfr266 APN 3 106821995 missense possibly damaging 0.82
IGL02371:Olfr266 APN 3 106822046 missense probably damaging 1.00
IGL02792:Olfr266 APN 3 106822140 missense probably damaging 0.98
PIT4131001:Olfr266 UTSW 3 106821966 missense probably benign 0.00
R0540:Olfr266 UTSW 3 106822513 missense probably damaging 0.99
R1925:Olfr266 UTSW 3 106822372 missense probably damaging 0.98
R2026:Olfr266 UTSW 3 106821711 missense probably benign 0.01
R4195:Olfr266 UTSW 3 106822012 nonsense probably null
R4735:Olfr266 UTSW 3 106821680 missense probably damaging 1.00
R4789:Olfr266 UTSW 3 106822292 missense possibly damaging 0.94
R4789:Olfr266 UTSW 3 106822308 missense possibly damaging 0.95
R4922:Olfr266 UTSW 3 106822260 missense probably damaging 0.99
R6318:Olfr266 UTSW 3 106822187 missense probably damaging 1.00
R6359:Olfr266 UTSW 3 106822415 missense probably damaging 0.99
R6505:Olfr266 UTSW 3 106822322 missense possibly damaging 0.87
Posted On2014-05-07