Incidental Mutation 'IGL01869:Vmn1r60'
ID178651
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r60
Ensembl Gene ENSMUSG00000090794
Gene Namevomeronasal 1 receptor 60
SynonymsGm7184
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL01869
Quality Score
Status
Chromosome7
Chromosomal Location5544172-5545178 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 5544229 bp
ZygosityHeterozygous
Amino Acid Change Valine to Methionine at position 291 (V291M)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173782]
Predicted Effect probably benign
Transcript: ENSMUST00000172111
AA Change: V291M

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000133113
Gene: ENSMUSG00000090794
AA Change: V291M

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 1.1e-10 PFAM
Pfam:7tm_1 20 280 7.3e-12 PFAM
Pfam:V1R 31 299 1.3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173782
AA Change: V291M

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000133943
Gene: ENSMUSG00000090794
AA Change: V291M

DomainStartEndE-ValueType
Pfam:TAS2R 8 304 4.7e-10 PFAM
Pfam:7tm_1 30 289 7.2e-6 PFAM
Pfam:V1R 41 309 1.8e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700026F02Rik A G 8: 71,043,045 noncoding transcript Het
Adam29 T C 8: 55,871,697 H574R probably damaging Het
Arap1 C A 7: 101,400,283 T984K probably damaging Het
Ccdc146 A T 5: 21,316,839 S396T probably benign Het
Col6a3 T C 1: 90,773,048 K2587E unknown Het
Cyp3a44 A G 5: 145,790,686 S278P probably damaging Het
Daw1 T G 1: 83,182,244 probably benign Het
Dnah17 T C 11: 118,052,676 K3200R probably benign Het
Efhd2 A G 4: 141,874,602 F89S probably damaging Het
Fras1 A G 5: 96,708,783 probably benign Het
Ggps1 T C 13: 14,054,394 D68G probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm3604 A T 13: 62,370,140 C134S probably damaging Het
Gpaa1 A G 15: 76,332,998 T178A probably benign Het
Lama3 A G 18: 12,524,763 N312S possibly damaging Het
Npepps T C 11: 97,236,122 I437M probably damaging Het
Olfr1495 A G 19: 13,769,170 D276G probably benign Het
Olfr266 C T 3: 106,822,026 D178N probably benign Het
Rcor1 C A 12: 111,103,759 T330K possibly damaging Het
Sbno2 A G 10: 80,060,392 probably null Het
Sema3g A G 14: 31,223,667 E478G probably damaging Het
Smg9 A G 7: 24,416,524 D280G probably damaging Het
Smtnl1 A T 2: 84,811,397 *460R probably null Het
Syde1 A G 10: 78,588,919 C360R possibly damaging Het
Szt2 A G 4: 118,399,071 V197A possibly damaging Het
Tnrc6c T C 11: 117,755,448 V1405A possibly damaging Het
Ttbk1 A G 17: 46,447,063 S882P probably damaging Het
Tubgcp4 T A 2: 121,175,788 H116Q possibly damaging Het
Vmn1r192 T A 13: 22,187,580 N157Y probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Xpo5 C T 17: 46,242,207 P1184L possibly damaging Het
Zfp946 T G 17: 22,454,703 I146S probably benign Het
Other mutations in Vmn1r60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01892:Vmn1r60 APN 7 5544310 missense probably benign 0.02
IGL02427:Vmn1r60 APN 7 5544781 missense probably damaging 1.00
IGL03071:Vmn1r60 APN 7 5544369 missense probably damaging 0.97
R0200:Vmn1r60 UTSW 7 5544380 missense probably benign
R0457:Vmn1r60 UTSW 7 5545119 start gained probably benign
R1175:Vmn1r60 UTSW 7 5544622 missense probably benign 0.01
R1199:Vmn1r60 UTSW 7 5544972 missense probably damaging 0.99
R1529:Vmn1r60 UTSW 7 5544903 missense probably benign 0.00
R1859:Vmn1r60 UTSW 7 5544550 missense possibly damaging 0.64
R2033:Vmn1r60 UTSW 7 5544820 missense probably benign
R2405:Vmn1r60 UTSW 7 5544913 missense probably benign
R3408:Vmn1r60 UTSW 7 5545149 utr 5 prime probably null
R3771:Vmn1r60 UTSW 7 5544711 missense possibly damaging 0.76
R3773:Vmn1r60 UTSW 7 5544711 missense possibly damaging 0.76
R3852:Vmn1r60 UTSW 7 5545027 missense possibly damaging 0.79
R4236:Vmn1r60 UTSW 7 5544804 missense probably benign 0.06
R4331:Vmn1r60 UTSW 7 5544365 nonsense probably null
R4439:Vmn1r60 UTSW 7 5544489 missense probably damaging 1.00
R5099:Vmn1r60 UTSW 7 5544817 missense probably damaging 0.98
R5325:Vmn1r60 UTSW 7 5544202 missense probably benign
R5415:Vmn1r60 UTSW 7 5544417 missense probably benign 0.38
R5818:Vmn1r60 UTSW 7 5545099 start codon destroyed probably benign 0.04
R6375:Vmn1r60 UTSW 7 5545018 missense probably damaging 0.96
R6378:Vmn1r60 UTSW 7 5544783 missense probably damaging 0.99
R6478:Vmn1r60 UTSW 7 5544865 missense probably damaging 1.00
R6572:Vmn1r60 UTSW 7 5544600 missense probably benign 0.40
R6586:Vmn1r60 UTSW 7 5544447 missense probably benign 0.00
R7061:Vmn1r60 UTSW 7 5544311 nonsense probably null
Posted On2014-05-07