Incidental Mutation 'IGL01876:Vmn1r6'
| ID |
178891 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r6
|
| Ensembl Gene |
ENSMUSG00000115701 |
| Gene Name |
vomeronasal 1 receptor 6 |
| Synonyms |
V1rc20 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
IGL01876
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
56979340-56980251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 56979446 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 36
(K36R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153988
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079669]
[ENSMUST00000226689]
[ENSMUST00000227131]
[ENSMUST00000227188]
[ENSMUST00000227631]
[ENSMUST00000227847]
[ENSMUST00000228285]
|
| AlphaFold |
Q8R2D4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079669
AA Change: K36R
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: K36R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
4.9e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226689
AA Change: K36R
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227131
AA Change: K36R
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227188
AA Change: K14R
PolyPhen 2
Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227631
AA Change: K14R
PolyPhen 2
Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227847
AA Change: K36R
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228285
AA Change: K36R
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aoc1l3 |
A |
T |
6: 48,966,970 (GRCm39) |
R639S |
possibly damaging |
Het |
| Aopep |
T |
C |
13: 63,338,336 (GRCm39) |
S570P |
probably damaging |
Het |
| Ap3b2 |
T |
A |
7: 81,123,602 (GRCm39) |
|
probably null |
Het |
| Api5 |
A |
G |
2: 94,249,299 (GRCm39) |
|
probably benign |
Het |
| Arhgap1 |
A |
G |
2: 91,480,564 (GRCm39) |
|
probably null |
Het |
| Cip2a |
T |
C |
16: 48,822,041 (GRCm39) |
V223A |
probably damaging |
Het |
| Cldn6 |
G |
T |
17: 23,900,158 (GRCm39) |
V41F |
probably damaging |
Het |
| Dctn1 |
G |
T |
6: 83,174,903 (GRCm39) |
V1032L |
probably damaging |
Het |
| Eef2 |
T |
A |
10: 81,016,104 (GRCm39) |
F488L |
probably benign |
Het |
| Fars2 |
A |
G |
13: 36,721,285 (GRCm39) |
T410A |
probably benign |
Het |
| Hnrnpc |
T |
C |
14: 52,319,330 (GRCm39) |
N91S |
probably null |
Het |
| Magel2 |
T |
C |
7: 62,028,575 (GRCm39) |
V493A |
possibly damaging |
Het |
| Odr4 |
G |
T |
1: 150,258,089 (GRCm39) |
T182N |
probably benign |
Het |
| Or4c117 |
A |
T |
2: 88,956,081 (GRCm39) |
|
probably null |
Het |
| Or5ac17 |
A |
G |
16: 59,036,382 (GRCm39) |
V198A |
possibly damaging |
Het |
| Pcnx2 |
G |
T |
8: 126,592,770 (GRCm39) |
S731R |
probably benign |
Het |
| Plekhm1 |
A |
G |
11: 103,267,577 (GRCm39) |
L798P |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,413,131 (GRCm39) |
E680G |
probably damaging |
Het |
| Rabggta |
T |
C |
14: 55,956,128 (GRCm39) |
T140A |
probably damaging |
Het |
| Slc2a1 |
G |
A |
4: 118,990,575 (GRCm39) |
D236N |
probably benign |
Het |
| Sp140l2 |
A |
G |
1: 85,231,907 (GRCm39) |
|
probably benign |
Het |
| Sptlc1 |
C |
A |
13: 53,528,048 (GRCm39) |
V39F |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Wdpcp |
T |
A |
11: 21,763,383 (GRCm39) |
D581E |
possibly damaging |
Het |
|
| Other mutations in Vmn1r6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00905:Vmn1r6
|
APN |
6 |
56,979,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01011:Vmn1r6
|
APN |
6 |
56,979,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01147:Vmn1r6
|
APN |
6 |
56,979,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01475:Vmn1r6
|
APN |
6 |
56,979,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01638:Vmn1r6
|
APN |
6 |
56,980,177 (GRCm39) |
nonsense |
probably null |
|
|
IGL01860:Vmn1r6
|
APN |
6 |
56,979,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL01988:Vmn1r6
|
APN |
6 |
56,979,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Vmn1r6
|
UTSW |
6 |
56,979,583 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1495:Vmn1r6
|
UTSW |
6 |
56,980,058 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1733:Vmn1r6
|
UTSW |
6 |
56,979,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Vmn1r6
|
UTSW |
6 |
56,980,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3625:Vmn1r6
|
UTSW |
6 |
56,979,920 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4353:Vmn1r6
|
UTSW |
6 |
56,979,677 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4484:Vmn1r6
|
UTSW |
6 |
56,980,174 (GRCm39) |
missense |
probably benign |
|
|
R4854:Vmn1r6
|
UTSW |
6 |
56,979,683 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5237:Vmn1r6
|
UTSW |
6 |
56,980,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5341:Vmn1r6
|
UTSW |
6 |
56,979,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn1r6
|
UTSW |
6 |
56,979,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6795:Vmn1r6
|
UTSW |
6 |
56,979,422 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8423:Vmn1r6
|
UTSW |
6 |
56,979,495 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9249:Vmn1r6
|
UTSW |
6 |
56,979,760 (GRCm39) |
missense |
probably benign |
|
|
R9582:Vmn1r6
|
UTSW |
6 |
56,979,925 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation