Incidental Mutation 'IGL01876:Odr4'
| ID |
178907 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Odr4
|
| Ensembl Gene |
ENSMUSG00000006010 |
| Gene Name |
odr4 GPCR localization factor homolog |
| Synonyms |
BC003331, 1810053E15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.783)
|
| Stock # |
IGL01876
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
150237056-150268831 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 150258089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Asparagine
at position 182
(T182N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107544
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006167]
[ENSMUST00000094477]
[ENSMUST00000097546]
[ENSMUST00000097547]
[ENSMUST00000111913]
|
| AlphaFold |
Q4PJX1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000006167
AA Change: T182N
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000006167
Gene: ENSMUSG00000006010
AA Change: T182N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094477
AA Change: T182N
PolyPhen 2
Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000092050
Gene: ENSMUSG00000006010
AA Change: T182N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
383 |
2.8e-120 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097546
AA Change: T182N
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000095152
Gene: ENSMUSG00000006010
AA Change: T182N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097547
AA Change: T182N
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000095153
Gene: ENSMUSG00000006010
AA Change: T182N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
209 |
1.2e-57 |
PFAM |
|
Pfam:ODR4-like
|
206 |
354 |
3.1e-43 |
PFAM |
|
transmembrane domain
|
392 |
414 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111913
AA Change: T182N
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000107544
Gene: ENSMUSG00000006010
AA Change: T182N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
386 |
7.1e-113 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132809
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148389
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150615
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aoc1l3 |
A |
T |
6: 48,966,970 (GRCm39) |
R639S |
possibly damaging |
Het |
| Aopep |
T |
C |
13: 63,338,336 (GRCm39) |
S570P |
probably damaging |
Het |
| Ap3b2 |
T |
A |
7: 81,123,602 (GRCm39) |
|
probably null |
Het |
| Api5 |
A |
G |
2: 94,249,299 (GRCm39) |
|
probably benign |
Het |
| Arhgap1 |
A |
G |
2: 91,480,564 (GRCm39) |
|
probably null |
Het |
| Cip2a |
T |
C |
16: 48,822,041 (GRCm39) |
V223A |
probably damaging |
Het |
| Cldn6 |
G |
T |
17: 23,900,158 (GRCm39) |
V41F |
probably damaging |
Het |
| Dctn1 |
G |
T |
6: 83,174,903 (GRCm39) |
V1032L |
probably damaging |
Het |
| Eef2 |
T |
A |
10: 81,016,104 (GRCm39) |
F488L |
probably benign |
Het |
| Fars2 |
A |
G |
13: 36,721,285 (GRCm39) |
T410A |
probably benign |
Het |
| Hnrnpc |
T |
C |
14: 52,319,330 (GRCm39) |
N91S |
probably null |
Het |
| Magel2 |
T |
C |
7: 62,028,575 (GRCm39) |
V493A |
possibly damaging |
Het |
| Or4c117 |
A |
T |
2: 88,956,081 (GRCm39) |
|
probably null |
Het |
| Or5ac17 |
A |
G |
16: 59,036,382 (GRCm39) |
V198A |
possibly damaging |
Het |
| Pcnx2 |
G |
T |
8: 126,592,770 (GRCm39) |
S731R |
probably benign |
Het |
| Plekhm1 |
A |
G |
11: 103,267,577 (GRCm39) |
L798P |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,413,131 (GRCm39) |
E680G |
probably damaging |
Het |
| Rabggta |
T |
C |
14: 55,956,128 (GRCm39) |
T140A |
probably damaging |
Het |
| Slc2a1 |
G |
A |
4: 118,990,575 (GRCm39) |
D236N |
probably benign |
Het |
| Sp140l2 |
A |
G |
1: 85,231,907 (GRCm39) |
|
probably benign |
Het |
| Sptlc1 |
C |
A |
13: 53,528,048 (GRCm39) |
V39F |
probably benign |
Het |
| Vmn1r6 |
A |
G |
6: 56,979,446 (GRCm39) |
K36R |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Wdpcp |
T |
A |
11: 21,763,383 (GRCm39) |
D581E |
possibly damaging |
Het |
|
| Other mutations in Odr4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02189:Odr4
|
APN |
1 |
150,247,784 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02257:Odr4
|
APN |
1 |
150,262,155 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02485:Odr4
|
APN |
1 |
150,239,240 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02585:Odr4
|
APN |
1 |
150,239,272 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02712:Odr4
|
APN |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02902:Odr4
|
APN |
1 |
150,260,179 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03014:Odr4
|
APN |
1 |
150,258,804 (GRCm39) |
splice site |
probably benign |
|
|
IGL03124:Odr4
|
APN |
1 |
150,262,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03181:Odr4
|
APN |
1 |
150,239,290 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03344:Odr4
|
APN |
1 |
150,239,295 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Odr4
|
UTSW |
1 |
150,262,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1796:Odr4
|
UTSW |
1 |
150,251,305 (GRCm39) |
missense |
probably benign |
|
|
R1902:Odr4
|
UTSW |
1 |
150,264,360 (GRCm39) |
splice site |
probably null |
|
|
R2149:Odr4
|
UTSW |
1 |
150,264,310 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2155:Odr4
|
UTSW |
1 |
150,258,086 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2375:Odr4
|
UTSW |
1 |
150,265,985 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3786:Odr4
|
UTSW |
1 |
150,260,282 (GRCm39) |
missense |
probably benign |
0.21 |
|
R3948:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R4589:Odr4
|
UTSW |
1 |
150,260,238 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4590:Odr4
|
UTSW |
1 |
150,262,103 (GRCm39) |
splice site |
probably null |
|
|
R4815:Odr4
|
UTSW |
1 |
150,250,597 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5196:Odr4
|
UTSW |
1 |
150,258,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5437:Odr4
|
UTSW |
1 |
150,239,269 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5549:Odr4
|
UTSW |
1 |
150,247,909 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5677:Odr4
|
UTSW |
1 |
150,250,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Odr4
|
UTSW |
1 |
150,256,111 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6472:Odr4
|
UTSW |
1 |
150,257,273 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7108:Odr4
|
UTSW |
1 |
150,258,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7402:Odr4
|
UTSW |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7662:Odr4
|
UTSW |
1 |
150,258,045 (GRCm39) |
missense |
probably benign |
|
|
R7767:Odr4
|
UTSW |
1 |
150,247,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7810:Odr4
|
UTSW |
1 |
150,268,659 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R7916:Odr4
|
UTSW |
1 |
150,260,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Odr4
|
UTSW |
1 |
150,260,177 (GRCm39) |
splice site |
probably null |
|
|
R8435:Odr4
|
UTSW |
1 |
150,258,020 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9397:Odr4
|
UTSW |
1 |
150,238,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation