Incidental Mutation 'IGL01878:Prl2c5'
ID178938
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl2c5
Ensembl Gene ENSMUSG00000055360
Gene Nameprolactin family 2, subfamily c, member 5
SynonymsMRP-4, PLF-4, Mrpplf4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL01878
Quality Score
Status
Chromosome13
Chromosomal Location13182715-13191923 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 13185817 bp
ZygosityHeterozygous
Amino Acid Change Serine to Asparagine at position 23 (S23N)
Ref Sequence ENSEMBL: ENSMUSP00000115024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021778] [ENSMUST00000126540] [ENSMUST00000151144]
Predicted Effect probably benign
Transcript: ENSMUST00000021778
AA Change: S20N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000021778
Gene: ENSMUSG00000055360
AA Change: S20N

DomainStartEndE-ValueType
Pfam:Hormone_1 16 222 2.7e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126540
AA Change: S23N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000115024
Gene: ENSMUSG00000055360
AA Change: S23N

DomainStartEndE-ValueType
Pfam:Hormone_1 19 225 1.5e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143335
Predicted Effect probably benign
Transcript: ENSMUST00000151144
AA Change: S20N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000117522
Gene: ENSMUSG00000055360
AA Change: S20N

DomainStartEndE-ValueType
Pfam:Hormone_1 16 172 3.5e-51 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox8 G T 11: 69,197,038 Q147K probably benign Het
Ankib1 T A 5: 3,734,152 M275L possibly damaging Het
Asb2 G A 12: 103,321,663 P546S possibly damaging Het
B9d1 T C 11: 61,507,623 probably benign Het
Col12a1 T C 9: 79,649,975 D1957G possibly damaging Het
Cryzl2 T C 1: 157,472,400 V44A possibly damaging Het
Fbxw19 A C 9: 109,483,279 probably benign Het
Gabrb3 T C 7: 57,816,415 F326L probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm11168 T C 9: 3,005,204 C16R probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm7808 T A 9: 19,928,246 probably benign Het
Gpam T C 19: 55,083,374 I312V probably benign Het
H2-M10.5 A G 17: 36,773,816 Y144C probably damaging Het
Hivep3 T C 4: 120,095,227 S247P possibly damaging Het
Hs3st4 T G 7: 124,397,313 C401G probably damaging Het
Klhl2 A G 8: 64,759,824 V227A probably damaging Het
Lct T C 1: 128,294,266 N1512S probably damaging Het
Lipm T A 19: 34,116,511 L276Q possibly damaging Het
Lmf2 T A 15: 89,352,418 H515L probably damaging Het
Mccc1 G A 3: 35,975,892 S423L probably damaging Het
Mettl21e G A 1: 44,211,033 S71L probably null Het
Muc16 T A 9: 18,495,543 H251L possibly damaging Het
Neb T C 2: 52,169,840 probably benign Het
Ntf5 T C 7: 45,416,026 I194T probably damaging Het
Olfr1124 T C 2: 87,434,970 I161T possibly damaging Het
Olfr1154 A T 2: 87,903,331 L115* probably null Het
Olfr1265 T C 2: 90,037,134 S72P probably damaging Het
Olfr1361 T C 13: 21,658,783 D180G possibly damaging Het
Olfr99 A G 17: 37,280,000 V140A possibly damaging Het
Pigv T C 4: 133,665,117 I247M probably benign Het
Pik3r5 A G 11: 68,492,530 N392D probably benign Het
Postn A G 3: 54,383,480 probably null Het
Prpf40b T C 15: 99,306,532 C220R possibly damaging Het
Pzp A G 6: 128,495,298 S843P probably damaging Het
Rpl23 C A 11: 97,778,351 R85L probably benign Het
Shcbp1 A G 8: 4,749,721 S252P probably damaging Het
Slc26a7 C T 4: 14,519,388 probably null Het
Sptbn4 T C 7: 27,364,146 E2285G probably damaging Het
Telo2 G T 17: 25,101,358 T784K probably benign Het
Tnfrsf19 C T 14: 60,996,644 V136M probably damaging Het
Trpm5 T A 7: 143,074,497 I22F probably damaging Het
Trpv6 G T 6: 41,626,867 probably benign Het
Vmn1r173 T G 7: 23,702,452 H37Q probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Xpo6 T A 7: 126,174,193 H20L probably benign Het
Zfp462 T C 4: 55,010,613 Y860H probably damaging Het
Other mutations in Prl2c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00910:Prl2c5 APN 13 13189476 critical splice donor site probably null
IGL01874:Prl2c5 APN 13 13190777 missense probably benign
R0178:Prl2c5 UTSW 13 13191805 missense probably damaging 0.98
R0276:Prl2c5 UTSW 13 13183049 intron probably benign
R0373:Prl2c5 UTSW 13 13183024 intron probably benign
R0539:Prl2c5 UTSW 13 13189321 intron probably null
R1037:Prl2c5 UTSW 13 13185907 nonsense probably null
R1296:Prl2c5 UTSW 13 13189424 missense probably damaging 1.00
R1458:Prl2c5 UTSW 13 13190725 missense probably benign 0.40
R1557:Prl2c5 UTSW 13 13190680 missense possibly damaging 0.52
R1850:Prl2c5 UTSW 13 13185792 missense probably benign 0.40
R1866:Prl2c5 UTSW 13 13190773 splice site probably null
R1894:Prl2c5 UTSW 13 13191678 missense probably benign 0.04
R2060:Prl2c5 UTSW 13 13190653 missense probably damaging 0.99
R2330:Prl2c5 UTSW 13 13191793 missense possibly damaging 0.67
R4755:Prl2c5 UTSW 13 13189385 missense probably benign
R5229:Prl2c5 UTSW 13 13185856 missense probably damaging 1.00
R5364:Prl2c5 UTSW 13 13183042 missense probably benign 0.01
R6307:Prl2c5 UTSW 13 13190590 missense probably benign 0.01
R6350:Prl2c5 UTSW 13 13183046 critical splice donor site probably null
R6927:Prl2c5 UTSW 13 13182918 intron probably null
R7397:Prl2c5 UTSW 13 13191742 missense probably benign 0.01
X0025:Prl2c5 UTSW 13 13191754 missense probably benign 0.03
Posted On2014-05-07