Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01878:Or1o4'

178955

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1o4

Ensembl Gene

ENSMUSG00000061972

Gene Name

olfactory receptor family 1 subfamily O member 4

Synonyms

MOR156-1, GA_x6K02T2PSCP-1720261-1719344, Olfr99

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.174) question?

Stock #

IGL01878

Quality Score

Status

Chromosome

Chromosomal Location

37590392-37591309 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 37590891 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 140 (V140A)

Ref Sequence

ENSEMBL: ENSMUSP00000148900 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077585] [ENSMUST00000216328]

AlphaFold

Q8VFE4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077585
AA Change: V140A

PolyPhen 2 Score 0.459 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000076781
Gene: ENSMUSG00000061972
AA Change: V140A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	1.8e-58	PFAM
Pfam:7TM_GPCR_Srsx	32	302	1.4e-6	PFAM
Pfam:7tm_1	38	287	1e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173568

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216328
AA Change: V140A

PolyPhen 2 Score 0.459 (Sensitivity: 0.89; Specificity: 0.90)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216370

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox8	G	T	11: 69,087,864 (GRCm39)	Q147K	probably benign	Het
Ankib1	T	A	5: 3,784,152 (GRCm39)	M275L	possibly damaging	Het
Asb2	G	A	12: 103,287,922 (GRCm39)	P546S	possibly damaging	Het
B9d1	T	C	11: 61,398,449 (GRCm39)		probably benign	Het
Col12a1	T	C	9: 79,557,257 (GRCm39)	D1957G	possibly damaging	Het
Cryzl2	T	C	1: 157,299,970 (GRCm39)	V44A	possibly damaging	Het
Fbxw19	A	C	9: 109,312,347 (GRCm39)		probably benign	Het
Gabrb3	T	C	7: 57,466,163 (GRCm39)	F326L	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm11168	T	C	9: 3,005,204 (GRCm39)	C16R	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm7808	T	A	9: 19,839,542 (GRCm39)		probably benign	Het
Gpam	T	C	19: 55,071,806 (GRCm39)	I312V	probably benign	Het
H2-M10.5	A	G	17: 37,084,708 (GRCm39)	Y144C	probably damaging	Het
Hivep3	T	C	4: 119,952,424 (GRCm39)	S247P	possibly damaging	Het
Hs3st4	T	G	7: 123,996,536 (GRCm39)	C401G	probably damaging	Het
Klhl2	A	G	8: 65,212,858 (GRCm39)	V227A	probably damaging	Het
Lct	T	C	1: 128,222,003 (GRCm39)	N1512S	probably damaging	Het
Lipm	T	A	19: 34,093,911 (GRCm39)	L276Q	possibly damaging	Het
Lmf2	T	A	15: 89,236,621 (GRCm39)	H515L	probably damaging	Het
Mccc1	G	A	3: 36,030,041 (GRCm39)	S423L	probably damaging	Het
Mettl21e	G	A	1: 44,250,193 (GRCm39)	S71L	probably null	Het
Muc16	T	A	9: 18,406,839 (GRCm39)	H251L	possibly damaging	Het
Neb	T	C	2: 52,059,852 (GRCm39)		probably benign	Het
Ntf5	T	C	7: 45,065,450 (GRCm39)	I194T	probably damaging	Het
Or10ag58	T	C	2: 87,265,314 (GRCm39)	I161T	possibly damaging	Het
Or2w6	T	C	13: 21,842,953 (GRCm39)	D180G	possibly damaging	Het
Or4x11	T	C	2: 89,867,478 (GRCm39)	S72P	probably damaging	Het
Or9m1	A	T	2: 87,733,675 (GRCm39)	L115*	probably null	Het
Pigv	T	C	4: 133,392,428 (GRCm39)	I247M	probably benign	Het
Pik3r5	A	G	11: 68,383,356 (GRCm39)	N392D	probably benign	Het
Postn	A	G	3: 54,290,901 (GRCm39)		probably null	Het
Prl2c5	G	A	13: 13,360,402 (GRCm39)	S23N	probably benign	Het
Prpf40b	T	C	15: 99,204,413 (GRCm39)	C220R	possibly damaging	Het
Pzp	A	G	6: 128,472,261 (GRCm39)	S843P	probably damaging	Het
Rpl23	C	A	11: 97,669,177 (GRCm39)	R85L	probably benign	Het
Shcbp1	A	G	8: 4,799,721 (GRCm39)	S252P	probably damaging	Het
Slc26a7	C	T	4: 14,519,388 (GRCm39)		probably null	Het
Sptbn4	T	C	7: 27,063,571 (GRCm39)	E2285G	probably damaging	Het
Telo2	G	T	17: 25,320,332 (GRCm39)	T784K	probably benign	Het
Tnfrsf19	C	T	14: 61,234,093 (GRCm39)	V136M	probably damaging	Het
Trpm5	T	A	7: 142,628,234 (GRCm39)	I22F	probably damaging	Het
Trpv6	G	T	6: 41,603,801 (GRCm39)		probably benign	Het
Vmn1r173	T	G	7: 23,401,877 (GRCm39)	H37Q	probably damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Xpo6	T	A	7: 125,773,365 (GRCm39)	H20L	probably benign	Het
Zfp462	T	C	4: 55,010,613 (GRCm39)	Y860H	probably damaging	Het

Other mutations in Or1o4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02954:Or1o4	APN	17	37,591,195 (GRCm39)	missense	probably damaging	1.00
R0533:Or1o4	UTSW	17	37,591,182 (GRCm39)	nonsense	probably null
R1480:Or1o4	UTSW	17	37,590,636 (GRCm39)	missense	probably benign	0.01
R2872:Or1o4	UTSW	17	37,590,867 (GRCm39)	missense	possibly damaging	0.64
R2872:Or1o4	UTSW	17	37,590,867 (GRCm39)	missense	possibly damaging	0.64
R3772:Or1o4	UTSW	17	37,590,745 (GRCm39)	missense	probably benign	0.00
R3826:Or1o4	UTSW	17	37,591,140 (GRCm39)	missense	probably damaging	1.00
R3827:Or1o4	UTSW	17	37,591,140 (GRCm39)	missense	probably damaging	1.00
R3829:Or1o4	UTSW	17	37,591,140 (GRCm39)	missense	probably damaging	1.00
R5210:Or1o4	UTSW	17	37,590,824 (GRCm39)	missense	probably benign	0.13
R5361:Or1o4	UTSW	17	37,590,501 (GRCm39)	missense	probably benign	0.02
R6213:Or1o4	UTSW	17	37,591,264 (GRCm39)	missense	probably benign
R6399:Or1o4	UTSW	17	37,590,666 (GRCm39)	missense	probably damaging	1.00
R6881:Or1o4	UTSW	17	37,591,200 (GRCm39)	missense	probably benign	0.01
R7938:Or1o4	UTSW	17	37,590,991 (GRCm39)	missense	probably benign	0.03
R8097:Or1o4	UTSW	17	37,590,818 (GRCm39)	nonsense	probably null
R8125:Or1o4	UTSW	17	37,590,935 (GRCm39)	missense	probably benign	0.01
R8218:Or1o4	UTSW	17	37,590,711 (GRCm39)	missense	probably benign
R9050:Or1o4	UTSW	17	37,590,820 (GRCm39)	missense	probably damaging	0.97
R9126:Or1o4	UTSW	17	37,590,745 (GRCm39)	missense	probably benign	0.00
R9434:Or1o4	UTSW	17	37,591,254 (GRCm39)	missense	probably benign	0.01
R9495:Or1o4	UTSW	17	37,591,386 (GRCm39)	start gained	probably benign
R9514:Or1o4	UTSW	17	37,591,386 (GRCm39)	start gained	probably benign
Z1176:Or1o4	UTSW	17	37,590,565 (GRCm39)	missense	probably damaging	0.99
Z1177:Or1o4	UTSW	17	37,591,100 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07