Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01891:Zc3h14'

179253

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zc3h14

Ensembl Gene

ENSMUSG00000021012

Gene Name

zinc finger CCCH type containing 14

Synonyms

2700069A02Rik, 1010001P15Rik, 1700016A15Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01891

Quality Score

Status

Chromosome

Chromosomal Location

98713223-98754012 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 98725206 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057000] [ENSMUST00000110104] [ENSMUST00000110105] [ENSMUST00000221532] [ENSMUST00000223083]

AlphaFold

Q8BJ05

Predicted Effect

probably benign
Transcript: ENSMUST00000057000

SMART Domains

Protein: ENSMUSP00000055879
Gene: ENSMUSG00000021012

Domain	Start	End	E-Value	Type
low complexity region	298	306	N/A	INTRINSIC
low complexity region	313	320	N/A	INTRINSIC
ZnF_C3H1	440	463	7.16e-1	SMART
ZnF_C3H1	465	484	5.27e1	SMART
ZnF_C3H1	520	542	5.55e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110104

SMART Domains

Protein: ENSMUSP00000105731
Gene: ENSMUSG00000021012

Domain	Start	End	E-Value	Type
low complexity region	298	306	N/A	INTRINSIC
low complexity region	313	320	N/A	INTRINSIC
ZnF_C3H1	465	488	7.16e-1	SMART
ZnF_C3H1	490	509	5.27e1	SMART
ZnF_C3H1	545	567	5.55e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110105

SMART Domains

Protein: ENSMUSP00000105732
Gene: ENSMUSG00000021012

Domain	Start	End	E-Value	Type
low complexity region	298	306	N/A	INTRINSIC
low complexity region	313	320	N/A	INTRINSIC
ZnF_C3H1	596	619	7.16e-1	SMART
ZnF_C3H1	621	640	5.27e1	SMART
ZnF_C3H1	676	698	5.55e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000221532

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221576

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222461

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222913

Predicted Effect

probably benign
Transcript: ENSMUST00000223083

Predicted Effect

probably benign
Transcript: ENSMUST00000223451

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous knockout results in impaired spatial working memory, enlarged anterior lateral ventricles in the brain, small testes and reduced litter size. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acnat2	T	C	4: 49,383,395 (GRCm39)	T53A	probably benign	Het
Aoc1	A	G	6: 48,885,776 (GRCm39)		probably benign	Het
Ctsf	G	A	19: 4,906,595 (GRCm39)	R174Q	probably damaging	Het
Ddo	T	C	10: 40,523,643 (GRCm39)	V211A	possibly damaging	Het
Ermp1	T	C	19: 29,594,002 (GRCm39)	I723V	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
H2-M3	T	G	17: 37,583,608 (GRCm39)	I322S	probably benign	Het
Npc1l1	T	C	11: 6,164,280 (GRCm39)	T1206A	probably damaging	Het
Pold3	A	T	7: 99,737,352 (GRCm39)		probably benign	Het
Ripor3	T	C	2: 167,825,071 (GRCm39)	T813A	possibly damaging	Het
Suco	T	C	1: 161,666,371 (GRCm39)	N510D	probably damaging	Het
Tas2r120	A	G	6: 132,634,807 (GRCm39)	*296W	probably null	Het
Tox2	G	T	2: 163,164,903 (GRCm39)	K514N	possibly damaging	Het
Ubr4	G	A	4: 139,163,571 (GRCm39)		probably null	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Zbtb1	T	A	12: 76,432,435 (GRCm39)	F140L	probably damaging	Het

Other mutations in Zc3h14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00835:Zc3h14	APN	12	98,713,783 (GRCm39)	critical splice donor site	probably null
IGL00946:Zc3h14	APN	12	98,726,142 (GRCm39)	splice site	probably benign
IGL00969:Zc3h14	APN	12	98,725,102 (GRCm39)	missense	probably benign	0.00
IGL01626:Zc3h14	APN	12	98,745,445 (GRCm39)	missense	possibly damaging	0.72
IGL02119:Zc3h14	APN	12	98,730,154 (GRCm39)	missense	probably benign	0.00
IGL02484:Zc3h14	APN	12	98,740,560 (GRCm39)	missense	probably benign	0.14
IGL02744:Zc3h14	APN	12	98,751,234 (GRCm39)	missense	possibly damaging	0.67
IGL02894:Zc3h14	APN	12	98,725,202 (GRCm39)	critical splice donor site	probably null
R0408:Zc3h14	UTSW	12	98,730,082 (GRCm39)	missense	probably damaging	1.00
R0739:Zc3h14	UTSW	12	98,723,460 (GRCm39)	missense	probably damaging	0.99
R0865:Zc3h14	UTSW	12	98,745,528 (GRCm39)	critical splice donor site	probably null
R0926:Zc3h14	UTSW	12	98,724,849 (GRCm39)	missense	possibly damaging	0.94
R1530:Zc3h14	UTSW	12	98,751,262 (GRCm39)	missense	probably damaging	1.00
R1735:Zc3h14	UTSW	12	98,724,839 (GRCm39)	missense	probably damaging	1.00
R1743:Zc3h14	UTSW	12	98,745,448 (GRCm39)	missense	probably benign	0.04
R1848:Zc3h14	UTSW	12	98,719,091 (GRCm39)	missense	possibly damaging	0.89
R1851:Zc3h14	UTSW	12	98,726,613 (GRCm39)	nonsense	probably null
R1978:Zc3h14	UTSW	12	98,730,181 (GRCm39)	missense	probably damaging	0.97
R2011:Zc3h14	UTSW	12	98,746,527 (GRCm39)	missense	possibly damaging	0.76
R2198:Zc3h14	UTSW	12	98,719,069 (GRCm39)	missense	possibly damaging	0.94
R2198:Zc3h14	UTSW	12	98,719,068 (GRCm39)	missense	probably damaging	1.00
R2263:Zc3h14	UTSW	12	98,724,773 (GRCm39)	missense	probably benign	0.32
R3762:Zc3h14	UTSW	12	98,724,902 (GRCm39)	missense	probably damaging	1.00
R4210:Zc3h14	UTSW	12	98,751,658 (GRCm39)	missense	probably damaging	1.00
R4353:Zc3h14	UTSW	12	98,730,219 (GRCm39)	missense	possibly damaging	0.70
R4360:Zc3h14	UTSW	12	98,746,456 (GRCm39)	missense	probably benign	0.09
R4814:Zc3h14	UTSW	12	98,719,107 (GRCm39)	missense	probably damaging	1.00
R4815:Zc3h14	UTSW	12	98,719,107 (GRCm39)	missense	probably damaging	1.00
R4817:Zc3h14	UTSW	12	98,719,107 (GRCm39)	missense	probably damaging	1.00
R4947:Zc3h14	UTSW	12	98,726,083 (GRCm39)	missense	probably benign
R5077:Zc3h14	UTSW	12	98,723,465 (GRCm39)	critical splice donor site	probably null
R5431:Zc3h14	UTSW	12	98,746,324 (GRCm39)	missense	possibly damaging	0.94
R5783:Zc3h14	UTSW	12	98,723,434 (GRCm39)	missense	probably damaging	0.99
R5850:Zc3h14	UTSW	12	98,745,414 (GRCm39)	missense	probably damaging	0.97
R6034:Zc3h14	UTSW	12	98,737,632 (GRCm39)	missense	probably benign	0.01
R6034:Zc3h14	UTSW	12	98,737,632 (GRCm39)	missense	probably benign	0.01
R6291:Zc3h14	UTSW	12	98,726,087 (GRCm39)	missense	probably damaging	1.00
R6338:Zc3h14	UTSW	12	98,724,849 (GRCm39)	missense	possibly damaging	0.94
R6595:Zc3h14	UTSW	12	98,723,285 (GRCm39)	missense	probably damaging	0.98
R6737:Zc3h14	UTSW	12	98,751,305 (GRCm39)	missense	probably damaging	1.00
R6932:Zc3h14	UTSW	12	98,737,336 (GRCm39)	intron	probably benign
R7074:Zc3h14	UTSW	12	98,724,859 (GRCm39)	missense	possibly damaging	0.96
R7204:Zc3h14	UTSW	12	98,737,615 (GRCm39)	missense	probably damaging	1.00
R7237:Zc3h14	UTSW	12	98,746,408 (GRCm39)	missense	probably benign	0.34
R7267:Zc3h14	UTSW	12	98,751,988 (GRCm39)	missense	probably damaging	1.00
R8753:Zc3h14	UTSW	12	98,724,831 (GRCm39)	missense	probably benign	0.12
R9169:Zc3h14	UTSW	12	98,745,505 (GRCm39)	missense	probably damaging	1.00
R9610:Zc3h14	UTSW	12	98,737,663 (GRCm39)	missense	possibly damaging	0.92
RF020:Zc3h14	UTSW	12	98,746,541 (GRCm39)	critical splice donor site	probably null
RF024:Zc3h14	UTSW	12	98,725,120 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07