Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01892:Cyp2c68'

179257

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c68

Ensembl Gene

ENSMUSG00000074882

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 68

Synonyms

9030012A22Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01892

Quality Score

Status

Chromosome

Chromosomal Location

39677278-39729498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 39722788 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 253 (E253D)

Ref Sequence

ENSEMBL: ENSMUSP00000097071 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099472]

AlphaFold

K7N6C2

Predicted Effect

probably benign
Transcript: ENSMUST00000099472
AA Change: E253D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097071
Gene: ENSMUSG00000074882
AA Change: E253D

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	2.1e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cplane1	A	T	15: 8,271,749 (GRCm39)		probably benign	Het
Gbp2b	A	G	3: 142,309,381 (GRCm39)	D164G	probably benign	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Lct	G	T	1: 128,235,342 (GRCm39)	T555N	probably damaging	Het
Ncam2	T	A	16: 81,386,587 (GRCm39)	H655Q	possibly damaging	Het
Or52a24	A	T	7: 103,381,687 (GRCm39)	M185L	possibly damaging	Het
Or8b57	C	A	9: 40,004,114 (GRCm39)	L45F	probably damaging	Het
Pglyrp4	A	G	3: 90,646,348 (GRCm39)	N293S	probably benign	Het
Pofut2	C	A	10: 77,101,717 (GRCm39)	D251E	probably benign	Het
Prdm2	T	C	4: 142,860,974 (GRCm39)	E772G	probably damaging	Het
Prkd3	A	T	17: 79,279,930 (GRCm39)	D254E	probably benign	Het
Prr36	G	A	8: 4,265,243 (GRCm39)	P169L	probably damaging	Het
Pwp2	T	C	10: 78,014,841 (GRCm39)	Y381C	probably damaging	Het
Rasgrp1	G	A	2: 117,124,323 (GRCm39)	T293M	probably damaging	Het
Snd1	G	A	6: 28,888,123 (GRCm39)		probably null	Het
Suclg2	A	T	6: 95,556,169 (GRCm39)	D237E	probably damaging	Het
Tenm3	T	C	8: 48,729,431 (GRCm39)	N1509S	probably benign	Het
Thbd	A	T	2: 148,248,988 (GRCm39)	H293Q	possibly damaging	Het
Tie1	T	A	4: 118,333,115 (GRCm39)	Y871F	probably benign	Het
Vmn1r38	A	T	6: 66,753,360 (GRCm39)	V252D	probably benign	Het
Vmn1r60	C	A	7: 5,547,309 (GRCm39)	V264F	probably benign	Het
Vmn1r68	T	C	7: 10,261,334 (GRCm39)	T255A	possibly damaging	Het
Vmn2r49	A	T	7: 9,718,690 (GRCm39)	V458E	probably benign	Het
Vmn2r9	A	T	5: 108,995,700 (GRCm39)	V316D	probably damaging	Het
Wfdc15b	A	T	2: 164,057,388 (GRCm39)	M1K	probably null	Het

Other mutations in Cyp2c68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Cyp2c68	APN	19	39,700,939 (GRCm39)	missense	probably damaging	0.98
IGL00826:Cyp2c68	APN	19	39,727,949 (GRCm39)	missense	possibly damaging	0.87
IGL01363:Cyp2c68	APN	19	39,691,871 (GRCm39)	missense	probably benign	0.01
IGL02088:Cyp2c68	APN	19	39,691,965 (GRCm39)	splice site	probably benign
IGL02422:Cyp2c68	APN	19	39,722,896 (GRCm39)	missense	probably damaging	1.00
IGL03047:Cyp2c68	UTSW	19	39,722,904 (GRCm39)	missense	probably benign	0.00
R0523:Cyp2c68	UTSW	19	39,727,873 (GRCm39)	missense	probably benign	0.08
R0729:Cyp2c68	UTSW	19	39,727,994 (GRCm39)	splice site	probably benign
R0975:Cyp2c68	UTSW	19	39,691,802 (GRCm39)	missense	possibly damaging	0.85
R1117:Cyp2c68	UTSW	19	39,700,903 (GRCm39)	missense	probably damaging	1.00
R1355:Cyp2c68	UTSW	19	39,729,400 (GRCm39)	missense	probably damaging	1.00
R1370:Cyp2c68	UTSW	19	39,729,400 (GRCm39)	missense	probably damaging	1.00
R1436:Cyp2c68	UTSW	19	39,729,484 (GRCm39)	start codon destroyed	probably null	1.00
R1564:Cyp2c68	UTSW	19	39,724,024 (GRCm39)	nonsense	probably null
R1730:Cyp2c68	UTSW	19	39,687,719 (GRCm39)	missense	possibly damaging	0.87
R1865:Cyp2c68	UTSW	19	39,722,733 (GRCm39)	missense	probably benign	0.04
R1905:Cyp2c68	UTSW	19	39,724,026 (GRCm39)	missense	probably benign	0.01
R1951:Cyp2c68	UTSW	19	39,700,972 (GRCm39)	missense	probably benign	0.22
R1952:Cyp2c68	UTSW	19	39,700,972 (GRCm39)	missense	probably benign	0.22
R2224:Cyp2c68	UTSW	19	39,724,026 (GRCm39)	missense	probably benign	0.34
R2230:Cyp2c68	UTSW	19	39,687,804 (GRCm39)	missense	probably benign	0.07
R2231:Cyp2c68	UTSW	19	39,687,804 (GRCm39)	missense	probably benign	0.07
R2866:Cyp2c68	UTSW	19	39,677,589 (GRCm39)	missense	probably damaging	1.00
R3104:Cyp2c68	UTSW	19	39,722,757 (GRCm39)	missense	probably benign
R4409:Cyp2c68	UTSW	19	39,727,896 (GRCm39)	missense	probably damaging	0.98
R4575:Cyp2c68	UTSW	19	39,722,805 (GRCm39)	missense	probably benign	0.21
R4620:Cyp2c68	UTSW	19	39,701,006 (GRCm39)	splice site	probably null
R4684:Cyp2c68	UTSW	19	39,687,779 (GRCm39)	missense	possibly damaging	0.48
R5023:Cyp2c68	UTSW	19	39,700,951 (GRCm39)	missense	probably benign	0.01
R5410:Cyp2c68	UTSW	19	39,687,728 (GRCm39)	missense	possibly damaging	0.65
R5513:Cyp2c68	UTSW	19	39,691,850 (GRCm39)	missense	probably damaging	1.00
R5568:Cyp2c68	UTSW	19	39,677,526 (GRCm39)	missense	probably benign	0.19
R5706:Cyp2c68	UTSW	19	39,722,762 (GRCm39)	missense	possibly damaging	0.95
R5890:Cyp2c68	UTSW	19	39,700,936 (GRCm39)	missense	probably damaging	1.00
R5897:Cyp2c68	UTSW	19	39,700,975 (GRCm39)	missense	probably benign	0.01
R6007:Cyp2c68	UTSW	19	39,722,780 (GRCm39)	missense	probably damaging	1.00
R6132:Cyp2c68	UTSW	19	39,691,858 (GRCm39)	missense	possibly damaging	0.90
R6187:Cyp2c68	UTSW	19	39,729,452 (GRCm39)	missense	probably benign	0.32
R6229:Cyp2c68	UTSW	19	39,727,622 (GRCm39)	missense	probably benign	0.02
R6341:Cyp2c68	UTSW	19	39,700,933 (GRCm39)	missense	possibly damaging	0.54
R7209:Cyp2c68	UTSW	19	39,677,649 (GRCm39)	missense	probably damaging	1.00
R7330:Cyp2c68	UTSW	19	39,677,634 (GRCm39)	missense	probably damaging	1.00
R7374:Cyp2c68	UTSW	19	39,727,648 (GRCm39)	critical splice acceptor site	probably null
R7402:Cyp2c68	UTSW	19	39,729,318 (GRCm39)	missense	probably benign	0.02
R7483:Cyp2c68	UTSW	19	39,677,581 (GRCm39)	missense	probably benign	0.02
R9103:Cyp2c68	UTSW	19	39,727,625 (GRCm39)	missense	possibly damaging	0.95
R9204:Cyp2c68	UTSW	19	39,727,571 (GRCm39)	missense	probably damaging	1.00
R9452:Cyp2c68	UTSW	19	39,687,833 (GRCm39)	missense	possibly damaging	0.75
Z1088:Cyp2c68	UTSW	19	39,727,907 (GRCm39)	missense	probably damaging	0.96

Posted On

2014-05-07