Incidental Mutation 'IGL01893:Serpinb11'
ID179283
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serpinb11
Ensembl Gene ENSMUSG00000026327
Gene Nameserine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms2310046M08Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01893
Quality Score
Status
Chromosome1
Chromosomal Location107361198-107380475 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 107377657 bp
ZygosityHeterozygous
Amino Acid Change Serine to Arginine at position 254 (S254R)
Ref Sequence ENSEMBL: ENSMUSP00000027566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027566] [ENSMUST00000191425]
Predicted Effect probably benign
Transcript: ENSMUST00000027566
AA Change: S254R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027566
Gene: ENSMUSG00000026327
AA Change: S254R

DomainStartEndE-ValueType
SERPIN 13 388 4.33e-143 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191425
SMART Domains Protein: ENSMUSP00000141180
Gene: ENSMUSG00000026327

DomainStartEndE-ValueType
Pfam:Serpin 6 152 9.1e-35 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T A 3: 116,788,549 I275F probably damaging Het
Avil G A 10: 127,020,546 E815K possibly damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Car9 T A 4: 43,510,252 I278N probably damaging Het
Cast T A 13: 74,727,289 K480* probably null Het
Cenpj A G 14: 56,553,474 F373L probably damaging Het
Cspp1 T C 1: 10,134,141 probably null Het
Diaph3 G A 14: 86,918,852 T675I possibly damaging Het
Dip2b A T 15: 100,171,220 probably benign Het
Dnah1 T C 14: 31,266,470 D3425G probably damaging Het
Dolk A G 2: 30,285,914 Y40H probably benign Het
Drosha T C 15: 12,866,650 probably benign Het
Dusp15 A G 2: 152,949,036 probably null Het
Edrf1 T C 7: 133,657,102 F770L probably benign Het
Gabra1 T C 11: 42,133,759 K363R possibly damaging Het
Glipr1l1 A C 10: 112,076,169 T203P probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
H2-Q10 T C 17: 35,473,271 S270P probably damaging Het
Hipk2 A T 6: 38,818,395 M313K probably benign Het
Htt T A 5: 34,876,830 I1920N probably damaging Het
Lsr A T 7: 30,962,232 V210E possibly damaging Het
Mbtd1 A T 11: 93,921,412 I181L probably null Het
Mettl16 A T 11: 74,805,271 T273S possibly damaging Het
Mlst8 T C 17: 24,477,987 N74D probably benign Het
Nek9 A G 12: 85,336,400 I102T probably damaging Het
Nme7 C T 1: 164,345,281 A187V probably damaging Het
Nphp1 A T 2: 127,769,644 W261R probably damaging Het
Olfr1148 G T 2: 87,833,863 G275* probably null Het
Olfr1306 A T 2: 111,912,244 S229T possibly damaging Het
Olfr90 A G 17: 37,085,868 L99P probably damaging Het
Orc6 A G 8: 85,307,643 D165G probably damaging Het
Ovca2 A G 11: 75,178,307 S89P probably benign Het
Pcdhb12 T G 18: 37,437,210 S470A probably benign Het
Phactr2 T C 10: 13,247,188 T397A probably benign Het
Pms2 T C 5: 143,923,519 L50P probably damaging Het
Prr36 G A 8: 4,215,243 P169L probably damaging Het
Skap2 T C 6: 51,874,576 T79A probably damaging Het
Tbx19 A T 1: 165,140,198 S327T possibly damaging Het
Themis3 A G 17: 66,559,627 L206P possibly damaging Het
Tmem132c T A 5: 127,463,029 L373Q possibly damaging Het
Unc13c G T 9: 73,693,366 N1365K probably benign Het
Vmn2r106 A T 17: 20,277,468 M503K probably benign Het
Vmn2r33 A G 7: 7,563,777 I112T probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Vps13a A C 19: 16,663,775 W2328G probably damaging Het
Other mutations in Serpinb11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01487:Serpinb11 APN 1 107379838 missense probably benign 0.01
IGL01893:Serpinb11 APN 1 107377658 missense probably benign 0.01
IGL03011:Serpinb11 APN 1 107379816 missense probably damaging 1.00
IGL03126:Serpinb11 APN 1 107379924 missense probably damaging 1.00
R0138:Serpinb11 UTSW 1 107377530 missense probably damaging 1.00
R0153:Serpinb11 UTSW 1 107372203 missense probably benign 0.07
R0419:Serpinb11 UTSW 1 107376860 nonsense probably null
R1550:Serpinb11 UTSW 1 107379688 missense possibly damaging 0.94
R1764:Serpinb11 UTSW 1 107376802 missense probably benign 0.03
R1972:Serpinb11 UTSW 1 107369480 missense probably damaging 1.00
R3103:Serpinb11 UTSW 1 107377608 missense probably benign 0.07
R3768:Serpinb11 UTSW 1 107377662 critical splice donor site probably null
R4332:Serpinb11 UTSW 1 107369564 critical splice donor site probably null
R5001:Serpinb11 UTSW 1 107376868 missense possibly damaging 0.92
R5010:Serpinb11 UTSW 1 107379649 missense probably benign
R5043:Serpinb11 UTSW 1 107369465 missense probably damaging 0.97
R5186:Serpinb11 UTSW 1 107379754 missense probably damaging 1.00
R5833:Serpinb11 UTSW 1 107377662 critical splice donor site probably null
R5907:Serpinb11 UTSW 1 107372189 missense probably benign 0.12
R6244:Serpinb11 UTSW 1 107372242 missense probably damaging 0.99
R6395:Serpinb11 UTSW 1 107372051 intron probably null
R7111:Serpinb11 UTSW 1 107376884 missense probably benign 0.00
Posted On2014-05-07