Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01897:Zfp951'

179427

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp951

Ensembl Gene

ENSMUSG00000072774

Gene Name

zinc finger protein 951

Synonyms

Gm38611, C230055K05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

IGL01897

Quality Score

Status

Chromosome

Chromosomal Location

104961035-105007936 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 104963149 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Isoleucine at position 139 (S139I)

Ref Sequence

ENSEMBL: ENSMUSP00000087350 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089906] [ENSMUST00000186219]

AlphaFold

A0A087WRH0

Predicted Effect

probably benign
Transcript: ENSMUST00000089906
AA Change: S139I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000087350
Gene: ENSMUSG00000072774
AA Change: S139I

Domain	Start	End	E-Value	Type
KRAB	28	90	2e-14	SMART
ZnF_C2H2	176	198	2.79e-4	SMART
ZnF_C2H2	204	226	4.11e-2	SMART
ZnF_C2H2	232	254	3.11e-2	SMART
ZnF_C2H2	260	282	3.16e-3	SMART
ZnF_C2H2	288	310	2.53e-2	SMART
ZnF_C2H2	316	338	2.95e-3	SMART
ZnF_C2H2	344	366	1.18e-2	SMART
ZnF_C2H2	372	394	2.95e-3	SMART
ZnF_C2H2	400	422	2.57e-3	SMART
ZnF_C2H2	428	450	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186219
AA Change: S139I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000140625
Gene: ENSMUSG00000072774
AA Change: S139I

Domain	Start	End	E-Value	Type
KRAB	28	90	2e-14	SMART
ZnF_C2H2	176	198	2.79e-4	SMART
ZnF_C2H2	204	226	4.11e-2	SMART
ZnF_C2H2	232	254	3.11e-2	SMART
ZnF_C2H2	260	282	3.16e-3	SMART
ZnF_C2H2	288	310	2.53e-2	SMART
ZnF_C2H2	316	338	2.95e-3	SMART
ZnF_C2H2	344	366	1.18e-2	SMART
ZnF_C2H2	372	394	2.95e-3	SMART
ZnF_C2H2	400	422	2.57e-3	SMART
ZnF_C2H2	428	450	2.4e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr3	A	G	1: 125,346,025 (GRCm39)	Y21H	possibly damaging	Het
Adamts15	A	T	9: 30,813,448 (GRCm39)	S906T	probably damaging	Het
Brat1	A	G	5: 140,703,670 (GRCm39)	D641G	probably benign	Het
Ccdc42	G	A	11: 68,485,101 (GRCm39)	R205H	probably benign	Het
Cdadc1	T	C	14: 59,829,986 (GRCm39)		probably null	Het
Cfi	T	C	3: 129,652,034 (GRCm39)	V235A	probably damaging	Het
Ctps1	T	A	4: 120,424,476 (GRCm39)	D46V	probably damaging	Het
Cyb5d1	A	T	11: 69,284,587 (GRCm39)	D188E	probably benign	Het
Cyp19a1	G	T	9: 54,075,813 (GRCm39)	T414N	probably benign	Het
Cyp2c40	A	T	19: 39,792,217 (GRCm39)	C242*	probably null	Het
Eif3b	A	T	5: 140,411,202 (GRCm39)	T218S	possibly damaging	Het
Fasn	A	T	11: 120,698,765 (GRCm39)	L2475Q	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Heyl	A	T	4: 123,140,400 (GRCm39)	I320F	probably damaging	Het
Itpr3	T	A	17: 27,330,236 (GRCm39)	V1618E	probably damaging	Het
Kif7	A	T	7: 79,350,800 (GRCm39)	I1007N	probably damaging	Het
Lat2	A	G	5: 134,635,481 (GRCm39)		probably benign	Het
Lipm	A	T	19: 34,098,708 (GRCm39)	D394V	probably damaging	Het
Lmbrd1	T	A	1: 24,782,977 (GRCm39)	I307K	possibly damaging	Het
Mief1	T	C	15: 80,132,709 (GRCm39)		probably benign	Het
Mta2	C	T	19: 8,925,130 (GRCm39)	Q333*	probably null	Het
Neb	T	A	2: 52,170,587 (GRCm39)	E1695V	possibly damaging	Het
Npc1l1	A	T	11: 6,177,879 (GRCm39)	N510K	probably benign	Het
Or5af1	T	C	11: 58,722,465 (GRCm39)	F162L	probably damaging	Het
P2rx3	A	C	2: 84,853,825 (GRCm39)		probably benign	Het
Pdgfc	A	G	3: 81,111,639 (GRCm39)	E198G	possibly damaging	Het
Pkdcc	T	A	17: 83,527,548 (GRCm39)	I242N	probably damaging	Het
Pkn3	C	T	2: 29,972,824 (GRCm39)		probably benign	Het
Rcan2	T	G	17: 44,147,325 (GRCm39)	D54E	probably damaging	Het
Tmeff2	T	A	1: 51,171,369 (GRCm39)	Y202N	probably damaging	Het
Unc13c	A	G	9: 73,453,309 (GRCm39)	L1827P	probably damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Wfdc15a	G	T	2: 164,041,896 (GRCm39)	Q21K	probably benign	Het

Other mutations in Zfp951

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0594:Zfp951	UTSW	5	104,962,438 (GRCm39)	missense	possibly damaging	0.67
R1056:Zfp951	UTSW	5	104,963,151 (GRCm39)	missense	possibly damaging	0.90
R1857:Zfp951	UTSW	5	104,962,723 (GRCm39)	missense	probably damaging	0.97
R1967:Zfp951	UTSW	5	104,964,866 (GRCm39)	missense	possibly damaging	0.65
R2422:Zfp951	UTSW	5	104,963,143 (GRCm39)	missense	probably benign	0.14
R4358:Zfp951	UTSW	5	104,962,541 (GRCm39)	missense	probably damaging	1.00
R4671:Zfp951	UTSW	5	104,962,567 (GRCm39)	missense	probably benign	0.01
R5539:Zfp951	UTSW	5	104,962,712 (GRCm39)	missense	probably damaging	0.99
R5634:Zfp951	UTSW	5	104,963,155 (GRCm39)	missense	probably benign	0.00
R7894:Zfp951	UTSW	5	104,962,838 (GRCm39)	missense	probably benign	0.00
R8058:Zfp951	UTSW	5	104,962,312 (GRCm39)	missense	probably damaging	1.00
R8125:Zfp951	UTSW	5	104,963,169 (GRCm39)	nonsense	probably null
Z1177:Zfp951	UTSW	5	104,976,821 (GRCm39)	start codon destroyed	probably null	0.01

Posted On

2014-05-07