Incidental Mutation 'IGL01900:Vmn2r62'
| ID |
179499 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r62
|
| Ensembl Gene |
ENSMUSG00000091926 |
| Gene Name |
vomeronasal 2, receptor 62 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.127)
|
| Stock # |
IGL01900
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
42413862-42442920 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 42438495 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 114
(N114Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130557
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169130]
|
| AlphaFold |
K7N712 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169130
AA Change: N114Y
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000130557
Gene: ENSMUSG00000091926
AA Change: N114Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
2.1e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
2.7e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aoc2 |
T |
C |
11: 101,219,649 (GRCm39) |
Y627H |
probably damaging |
Het |
| Car14 |
T |
C |
3: 95,808,533 (GRCm39) |
D27G |
probably benign |
Het |
| Col6a3 |
A |
G |
1: 90,722,732 (GRCm39) |
|
probably null |
Het |
| Ddx60 |
T |
C |
8: 62,453,743 (GRCm39) |
|
probably benign |
Het |
| Dhrs4 |
A |
G |
14: 55,725,654 (GRCm39) |
E236G |
probably benign |
Het |
| Fpr1 |
T |
A |
17: 18,097,783 (GRCm39) |
T69S |
probably damaging |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,618,011 (GRCm39) |
|
probably benign |
Het |
| Hook2 |
T |
C |
8: 85,727,940 (GRCm39) |
|
probably benign |
Het |
| Krt6b |
C |
T |
15: 101,585,981 (GRCm39) |
R364H |
possibly damaging |
Het |
| Myh2 |
T |
A |
11: 67,074,609 (GRCm39) |
I720N |
probably benign |
Het |
| Optc |
A |
G |
1: 133,829,867 (GRCm39) |
V181A |
possibly damaging |
Het |
| Or52n5 |
A |
G |
7: 104,588,369 (GRCm39) |
D212G |
probably damaging |
Het |
| Ptprn |
A |
G |
1: 75,228,892 (GRCm39) |
|
probably benign |
Het |
| Rnf213 |
A |
G |
11: 119,333,841 (GRCm39) |
T3018A |
probably benign |
Het |
| Rps27l |
T |
A |
9: 66,854,225 (GRCm39) |
|
probably benign |
Het |
| Serpinb6c |
A |
T |
13: 34,064,173 (GRCm39) |
M294K |
possibly damaging |
Het |
| Spef1l |
A |
T |
7: 139,552,483 (GRCm39) |
V274E |
probably damaging |
Het |
| Tekt2 |
G |
T |
4: 126,218,421 (GRCm39) |
T83K |
probably benign |
Het |
|
| Other mutations in Vmn2r62 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01726:Vmn2r62
|
APN |
7 |
42,414,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r62
|
APN |
7 |
42,437,930 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02799:Vmn2r62
|
UTSW |
7 |
42,437,396 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0144:Vmn2r62
|
UTSW |
7 |
42,438,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r62
|
UTSW |
7 |
42,414,261 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1846:Vmn2r62
|
UTSW |
7 |
42,438,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3738:Vmn2r62
|
UTSW |
7 |
42,437,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4519:Vmn2r62
|
UTSW |
7 |
42,413,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Vmn2r62
|
UTSW |
7 |
42,414,240 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5381:Vmn2r62
|
UTSW |
7 |
42,437,219 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6855:Vmn2r62
|
UTSW |
7 |
42,438,412 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6872:Vmn2r62
|
UTSW |
7 |
42,438,412 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6968:Vmn2r62
|
UTSW |
7 |
42,437,866 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7030:Vmn2r62
|
UTSW |
7 |
42,438,473 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7067:Vmn2r62
|
UTSW |
7 |
42,414,302 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7148:Vmn2r62
|
UTSW |
7 |
42,414,640 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7305:Vmn2r62
|
UTSW |
7 |
42,414,235 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7493:Vmn2r62
|
UTSW |
7 |
42,437,316 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7583:Vmn2r62
|
UTSW |
7 |
42,437,466 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7593:Vmn2r62
|
UTSW |
7 |
42,437,213 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7851:Vmn2r62
|
UTSW |
7 |
42,438,539 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7974:Vmn2r62
|
UTSW |
7 |
42,437,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7974:Vmn2r62
|
UTSW |
7 |
42,414,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8085:Vmn2r62
|
UTSW |
7 |
42,437,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8514:Vmn2r62
|
UTSW |
7 |
42,413,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8935:Vmn2r62
|
UTSW |
7 |
42,437,791 (GRCm39) |
missense |
probably benign |
|
|
R9053:Vmn2r62
|
UTSW |
7 |
42,413,920 (GRCm39) |
missense |
|
|
|
| Posted On |
2014-05-07 |
Incidental Mutation