Incidental Mutation 'IGL01901:Vmn1r75'
ID179519
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Namevomeronasal 1 receptor 75
SynonymsV1rg6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL01901
Quality Score
Status
Chromosome7
Chromosomal Location11874630-11884307 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 11880812 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 157 (Y157C)
Ref Sequence ENSEMBL: ENSMUSP00000154577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
Predicted Effect probably damaging
Transcript: ENSMUST00000057229
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: Y157C

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226622
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000226855
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227611
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228268
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228463
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228646
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik A G 1: 26,682,584 F1172L probably benign Het
Adam2 A G 14: 66,035,229 probably benign Het
Aldh1a7 T G 19: 20,717,739 Y154S probably damaging Het
BC117090 C A 16: 36,334,263 A11S probably damaging Het
Casc3 A G 11: 98,823,121 D393G probably damaging Het
Cd180 A G 13: 102,706,428 I661V probably benign Het
Cdh1 T C 8: 106,657,760 S287P probably damaging Het
Clnk T C 5: 38,794,978 N6S probably damaging Het
Cyp17a1 C T 19: 46,671,092 V100M possibly damaging Het
Ddhd2 A G 8: 25,748,594 V53A probably damaging Het
Elovl7 T A 13: 108,274,393 probably null Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm14180 A G 11: 99,734,227 S22P unknown Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Golga5 G A 12: 102,479,802 probably null Het
Gpr162 A T 6: 124,861,407 F93L possibly damaging Het
Kcnh8 G A 17: 52,894,120 probably benign Het
Lamp3 A T 16: 19,673,419 F358L probably damaging Het
Mdn1 T G 4: 32,669,591 D409E probably damaging Het
Ms4a10 T C 19: 10,963,010 D211G probably benign Het
Ms4a3 T C 19: 11,639,266 E4G possibly damaging Het
Myo15 A G 11: 60,527,434 probably benign Het
Olfr1257 A G 2: 89,881,482 I219V probably damaging Het
Olfr1448 T C 19: 12,919,583 H242R probably damaging Het
Olfr612 A T 7: 103,538,970 L88Q probably damaging Het
Olfr638 A G 7: 104,004,067 H264R probably damaging Het
Olfr698 A G 7: 106,752,545 V281A possibly damaging Het
Olfr815 A G 10: 129,901,853 F286L probably benign Het
Penk T C 4: 4,134,465 I61V probably benign Het
Pkhd1 T A 1: 20,220,083 K2860N probably benign Het
Prtg C T 9: 72,855,066 P492S probably damaging Het
Tdrd7 T C 4: 45,989,225 probably benign Het
Terf2ip A G 8: 112,012,068 N196S probably benign Het
Tgtp1 T C 11: 48,987,555 N108D possibly damaging Het
Thumpd3 A G 6: 113,059,971 H277R probably benign Het
Tshz2 T A 2: 169,885,536 L215Q possibly damaging Het
Ube3c T A 5: 29,668,007 V1015E probably damaging Het
Utrn T A 10: 12,640,928 K2307N probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02175:Vmn1r75 APN 7 11880847 missense probably damaging 1.00
IGL02399:Vmn1r75 APN 7 11881166 missense possibly damaging 0.82
IGL02648:Vmn1r75 APN 7 11881164 missense probably benign 0.04
IGL03372:Vmn1r75 APN 7 11880569 missense probably benign 0.29
R0538:Vmn1r75 UTSW 7 11880870 missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11881262 unclassified probably null
R3910:Vmn1r75 UTSW 7 11880830 missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11880982 missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11880480 missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11881051 missense probably damaging 1.00
R6230:Vmn1r75 UTSW 7 11881039 missense probably damaging 0.98
R6490:Vmn1r75 UTSW 7 11881076 missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11880956 missense probably damaging 0.98
Posted On2014-05-07