Incidental Mutation 'IGL01901:Ms4a10'
ID 179541
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ms4a10
Ensembl Gene ENSMUSG00000024731
Gene Name membrane-spanning 4-domains, subfamily A, member 10
Synonyms 2010001N17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL01901
Quality Score
Status
Chromosome 19
Chromosomal Location 10939657-10952034 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10940374 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 211 (D211G)
Ref Sequence ENSEMBL: ENSMUSP00000140111 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072748] [ENSMUST00000190246] [ENSMUST00000191343]
AlphaFold Q99N03
Predicted Effect probably benign
Transcript: ENSMUST00000072748
AA Change: D251G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072531
Gene: ENSMUSG00000024731
AA Change: D251G

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
Pfam:CD20 56 190 6e-10 PFAM
low complexity region 239 252 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000190246
SMART Domains Protein: ENSMUSP00000140826
Gene: ENSMUSG00000024731

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 39 53 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191343
AA Change: D211G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000140111
Gene: ENSMUSG00000024731
AA Change: D211G

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
Pfam:CD20 57 150 7.9e-14 PFAM
low complexity region 199 212 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A G 14: 66,272,678 (GRCm39) probably benign Het
Aldh1a7 T G 19: 20,695,103 (GRCm39) Y154S probably damaging Het
Casc3 A G 11: 98,713,947 (GRCm39) D393G probably damaging Het
Cd180 A G 13: 102,842,936 (GRCm39) I661V probably benign Het
Cdh1 T C 8: 107,384,392 (GRCm39) S287P probably damaging Het
Clnk T C 5: 38,952,321 (GRCm39) N6S probably damaging Het
Cstdc6 C A 16: 36,154,625 (GRCm39) A11S probably damaging Het
Cyp17a1 C T 19: 46,659,531 (GRCm39) V100M possibly damaging Het
Ddhd2 A G 8: 26,238,621 (GRCm39) V53A probably damaging Het
Elovl7 T A 13: 108,410,927 (GRCm39) probably null Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm14180 A G 11: 99,625,053 (GRCm39) S22P unknown Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Golga5 G A 12: 102,446,061 (GRCm39) probably null Het
Gpr162 A T 6: 124,838,370 (GRCm39) F93L possibly damaging Het
Kcnh8 G A 17: 53,201,148 (GRCm39) probably benign Het
Lamp3 A T 16: 19,492,169 (GRCm39) F358L probably damaging Het
Mdn1 T G 4: 32,669,591 (GRCm39) D409E probably damaging Het
Ms4a3 T C 19: 11,616,630 (GRCm39) E4G possibly damaging Het
Myo15a A G 11: 60,418,260 (GRCm39) probably benign Het
Or2ag16 A G 7: 106,351,752 (GRCm39) V281A possibly damaging Het
Or4c10b A G 2: 89,711,826 (GRCm39) I219V probably damaging Het
Or51aa2 A T 7: 103,188,177 (GRCm39) L88Q probably damaging Het
Or51q1c A G 7: 103,653,274 (GRCm39) H264R probably damaging Het
Or5b12 T C 19: 12,896,947 (GRCm39) H242R probably damaging Het
Or6c217 A G 10: 129,737,722 (GRCm39) F286L probably benign Het
Penk T C 4: 4,134,465 (GRCm39) I61V probably benign Het
Pkhd1 T A 1: 20,290,307 (GRCm39) K2860N probably benign Het
Prtg C T 9: 72,762,348 (GRCm39) P492S probably damaging Het
Spata31e2 A G 1: 26,721,665 (GRCm39) F1172L probably benign Het
Tdrd7 T C 4: 45,989,225 (GRCm39) probably benign Het
Terf2ip A G 8: 112,738,700 (GRCm39) N196S probably benign Het
Tgtp1 T C 11: 48,878,382 (GRCm39) N108D possibly damaging Het
Thumpd3 A G 6: 113,036,932 (GRCm39) H277R probably benign Het
Tshz2 T A 2: 169,727,456 (GRCm39) L215Q possibly damaging Het
Ube3c T A 5: 29,873,005 (GRCm39) V1015E probably damaging Het
Utrn T A 10: 12,516,672 (GRCm39) K2307N probably damaging Het
Vmn1r75 A G 7: 11,614,739 (GRCm39) Y157C probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Ms4a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03031:Ms4a10 APN 19 10,946,035 (GRCm39) missense probably benign 0.01
P0027:Ms4a10 UTSW 19 10,941,492 (GRCm39) missense probably damaging 0.99
R0863:Ms4a10 UTSW 19 10,945,957 (GRCm39) missense probably damaging 1.00
R1456:Ms4a10 UTSW 19 10,942,097 (GRCm39) missense possibly damaging 0.91
R1509:Ms4a10 UTSW 19 10,941,472 (GRCm39) missense probably benign 0.01
R1838:Ms4a10 UTSW 19 10,941,411 (GRCm39) missense possibly damaging 0.92
R4583:Ms4a10 UTSW 19 10,945,553 (GRCm39) missense possibly damaging 0.94
R4932:Ms4a10 UTSW 19 10,942,132 (GRCm39) missense probably damaging 1.00
R5548:Ms4a10 UTSW 19 10,945,484 (GRCm39) critical splice donor site probably null
R5819:Ms4a10 UTSW 19 10,946,054 (GRCm39) missense probably benign 0.00
R5952:Ms4a10 UTSW 19 10,941,486 (GRCm39) missense probably damaging 1.00
R7026:Ms4a10 UTSW 19 10,944,869 (GRCm39) splice site probably null
R8063:Ms4a10 UTSW 19 10,942,136 (GRCm39) missense probably benign 0.01
R8323:Ms4a10 UTSW 19 10,940,363 (GRCm39) nonsense probably null
R9616:Ms4a10 UTSW 19 10,944,440 (GRCm39) missense possibly damaging 0.47
R9631:Ms4a10 UTSW 19 10,944,451 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07