Incidental Mutation 'IGL01903:Leng9'
| ID |
179591 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Leng9
|
| Ensembl Gene |
ENSMUSG00000043432 |
| Gene Name |
leukocyte receptor cluster (LRC) member 9 |
| Synonyms |
9530024C23Rik, F630035L11Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
IGL01903
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
4151182-4152871 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 4151746 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 310
(A310V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000061079
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037472]
[ENSMUST00000058358]
[ENSMUST00000076831]
[ENSMUST00000121270]
[ENSMUST00000140410]
[ENSMUST00000143825]
|
| AlphaFold |
Q8BTN6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037472
|
| SMART Domains |
Protein: ENSMUSP00000046465
Gene: ENSMUSG00000035545
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
47 |
69 |
N/A |
INTRINSIC |
|
low complexity region
|
73 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
447 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
468 |
N/A |
INTRINSIC |
|
Pfam:SAC3_GANP
|
567 |
762 |
8.2e-66 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000058358
AA Change: A310V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000061079
Gene: ENSMUSG00000043432
AA Change: A310V
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C3H1
|
8 |
34 |
1.72e-4 |
SMART |
|
Pfam:DUF504
|
77 |
128 |
1.9e-11 |
PFAM |
|
Pfam:AKAP7_NLS
|
305 |
484 |
2.5e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076831
|
| SMART Domains |
Protein: ENSMUSP00000092508
Gene: ENSMUSG00000063838
| Domain | Start | End | E-Value | Type |
|---|
|
PBD
|
23 |
57 |
5.86e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121270
|
| SMART Domains |
Protein: ENSMUSP00000112428
Gene: ENSMUSG00000035545
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
47 |
69 |
N/A |
INTRINSIC |
|
low complexity region
|
73 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
447 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
468 |
N/A |
INTRINSIC |
|
Pfam:SAC3_GANP
|
567 |
764 |
7.4e-67 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127723
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140410
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143825
|
| SMART Domains |
Protein: ENSMUSP00000117257
Gene: ENSMUSG00000063838
| Domain | Start | End | E-Value | Type |
|---|
|
PBD
|
23 |
57 |
5.86e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146434
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
T |
A |
3: 121,949,050 (GRCm39) |
|
probably benign |
Het |
| Adad1 |
T |
A |
3: 37,139,231 (GRCm39) |
|
probably null |
Het |
| Asxl3 |
T |
A |
18: 22,567,633 (GRCm39) |
D70E |
probably benign |
Het |
| Atat1 |
T |
A |
17: 36,208,692 (GRCm39) |
I380L |
probably benign |
Het |
| Ccnj |
A |
G |
19: 40,834,454 (GRCm39) |
E351G |
probably damaging |
Het |
| Clca4b |
A |
T |
3: 144,634,020 (GRCm39) |
Y132N |
probably damaging |
Het |
| Cttnbp2 |
A |
C |
6: 18,501,964 (GRCm39) |
V16G |
probably damaging |
Het |
| Gcdh |
A |
T |
8: 85,615,233 (GRCm39) |
L389Q |
probably damaging |
Het |
| Ggta1 |
A |
T |
2: 35,292,569 (GRCm39) |
F258Y |
possibly damaging |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gm3696 |
T |
A |
14: 18,434,983 (GRCm39) |
|
probably benign |
Het |
| Gramd2b |
A |
T |
18: 56,607,101 (GRCm39) |
S72C |
probably damaging |
Het |
| Hal |
G |
A |
10: 93,336,469 (GRCm39) |
|
probably benign |
Het |
| Haus4 |
A |
T |
14: 54,779,886 (GRCm39) |
S288T |
possibly damaging |
Het |
| Herc1 |
A |
T |
9: 66,294,154 (GRCm39) |
K499* |
probably null |
Het |
| Hyou1 |
C |
T |
9: 44,292,438 (GRCm39) |
|
probably benign |
Het |
| Kng2 |
C |
T |
16: 22,806,540 (GRCm39) |
R553Q |
possibly damaging |
Het |
| Magi3 |
G |
T |
3: 103,958,526 (GRCm39) |
Q520K |
possibly damaging |
Het |
| Mark1 |
A |
G |
1: 184,661,577 (GRCm39) |
|
probably benign |
Het |
| Mybl1 |
T |
A |
1: 9,741,801 (GRCm39) |
|
probably null |
Het |
| Ncapd2 |
A |
G |
6: 125,154,423 (GRCm39) |
S598P |
probably benign |
Het |
| Or14j5 |
T |
C |
17: 37,920,758 (GRCm39) |
I295V |
possibly damaging |
Het |
| Or4k47 |
T |
C |
2: 111,452,003 (GRCm39) |
K139E |
probably benign |
Het |
| Or5a3 |
G |
A |
19: 12,400,047 (GRCm39) |
V125I |
probably benign |
Het |
| Or5aq1 |
A |
C |
2: 86,965,723 (GRCm39) |
|
probably null |
Het |
| Otud6b |
C |
T |
4: 14,818,458 (GRCm39) |
E148K |
probably benign |
Het |
| Pgghg |
A |
G |
7: 140,526,741 (GRCm39) |
Q686R |
probably benign |
Het |
| Pkhd1 |
C |
A |
1: 20,268,361 (GRCm39) |
C3339F |
probably damaging |
Het |
| Pla2g4a |
T |
C |
1: 149,716,370 (GRCm39) |
D697G |
possibly damaging |
Het |
| Serping1 |
A |
T |
2: 84,600,116 (GRCm39) |
|
probably null |
Het |
| Sfxn4 |
T |
C |
19: 60,847,118 (GRCm39) |
Y55C |
probably damaging |
Het |
| Sh3bp5l |
A |
G |
11: 58,236,864 (GRCm39) |
R274G |
probably damaging |
Het |
| Snx13 |
A |
G |
12: 35,135,968 (GRCm39) |
T88A |
probably benign |
Het |
| Spz1 |
G |
T |
13: 92,711,407 (GRCm39) |
N356K |
probably damaging |
Het |
| Taf2 |
A |
T |
15: 54,923,412 (GRCm39) |
F288L |
probably benign |
Het |
| Tti1 |
T |
C |
2: 157,842,542 (GRCm39) |
E829G |
probably benign |
Het |
| Ube2z |
T |
C |
11: 95,955,826 (GRCm39) |
D92G |
possibly damaging |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r7 |
A |
G |
3: 64,626,864 (GRCm39) |
Y142H |
probably benign |
Het |
| Zfp397 |
T |
A |
18: 24,093,086 (GRCm39) |
N190K |
probably benign |
Het |
|
| Other mutations in Leng9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01970:Leng9
|
APN |
7 |
4,151,326 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02197:Leng9
|
APN |
7 |
4,151,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Leng9
|
APN |
7 |
4,151,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1616:Leng9
|
UTSW |
7 |
4,151,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2352:Leng9
|
UTSW |
7 |
4,152,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Leng9
|
UTSW |
7 |
4,151,626 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4156:Leng9
|
UTSW |
7 |
4,152,433 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4832:Leng9
|
UTSW |
7 |
4,152,029 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4841:Leng9
|
UTSW |
7 |
4,152,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Leng9
|
UTSW |
7 |
4,152,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7468:Leng9
|
UTSW |
7 |
4,151,800 (GRCm39) |
missense |
probably benign |
|
|
R7627:Leng9
|
UTSW |
7 |
4,151,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7679:Leng9
|
UTSW |
7 |
4,152,659 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8885:Leng9
|
UTSW |
7 |
4,151,774 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8951:Leng9
|
UTSW |
7 |
4,152,782 (GRCm39) |
unclassified |
probably benign |
|
|
R9062:Leng9
|
UTSW |
7 |
4,151,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Leng9
|
UTSW |
7 |
4,152,657 (GRCm39) |
missense |
probably benign |
|
|
R9275:Leng9
|
UTSW |
7 |
4,151,447 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9418:Leng9
|
UTSW |
7 |
4,151,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9582:Leng9
|
UTSW |
7 |
4,152,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Leng9
|
UTSW |
7 |
4,152,382 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Posted On |
2014-05-07 |
Incidental Mutation