Incidental Mutation 'IGL01904:Zfand5'
ID179631
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfand5
Ensembl Gene ENSMUSG00000024750
Gene Namezinc finger, AN1-type domain 5
Synonyms2310057A04Rik, 5830475F03Rik, Zfp216, Za20d2
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.841) question?
Stock #IGL01904
Quality Score
Status
Chromosome19
Chromosomal Location21272278-21282289 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to T at 21279758 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025659] [ENSMUST00000149144] [ENSMUST00000152338]
Predicted Effect probably benign
Transcript: ENSMUST00000025659
SMART Domains Protein: ENSMUSP00000025659
Gene: ENSMUSG00000024750

DomainStartEndE-ValueType
ZnF_A20 11 35 1.91e-10 SMART
low complexity region 118 151 N/A INTRINSIC
ZnF_AN1 154 191 1.52e-18 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133175
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141568
Predicted Effect probably benign
Transcript: ENSMUST00000149144
SMART Domains Protein: ENSMUSP00000122782
Gene: ENSMUSG00000024750

DomainStartEndE-ValueType
ZnF_A20 11 35 1.91e-10 SMART
low complexity region 91 103 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000152338
SMART Domains Protein: ENSMUSP00000123555
Gene: ENSMUSG00000024750

DomainStartEndE-ValueType
ZnF_A20 11 35 1.2e-12 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice display resistance to age related obesity and resistance to induced muscular atrophy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N22Rik A C 5: 11,921,456 N125T probably benign Het
Dnah5 T C 15: 28,307,364 I1746T probably benign Het
Eml3 T C 19: 8,936,766 probably benign Het
Eml6 C A 11: 29,838,613 E491* probably null Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hs3st2 C T 7: 121,500,984 P351L probably damaging Het
Igf2r A T 17: 12,714,911 Y819N probably damaging Het
Kifc3 C A 8: 95,137,957 A42S possibly damaging Het
Mrps17 A G 5: 129,716,801 T20A probably damaging Het
Msh6 T C 17: 87,984,732 V305A probably benign Het
Olfr449 T C 6: 42,838,289 M136T possibly damaging Het
Olfr872 T G 9: 20,260,290 M150R probably damaging Het
Pappa2 A G 1: 158,783,941 L1484P probably damaging Het
Polr3c A T 3: 96,716,665 probably null Het
Ros1 C A 10: 52,077,911 E1877D probably damaging Het
Slc5a4b T C 10: 76,060,426 N565S probably damaging Het
Slf2 T C 19: 44,949,141 probably null Het
Suclg2 A T 6: 95,588,934 probably benign Het
Sult2a8 T C 7: 14,425,457 E79G probably damaging Het
Triobp A G 15: 78,967,364 T573A possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfhx4 C A 3: 5,412,709 H3461Q probably damaging Het
Other mutations in Zfand5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0089:Zfand5 UTSW 19 21279758 unclassified probably benign
R0321:Zfand5 UTSW 19 21276515 missense probably damaging 1.00
R1766:Zfand5 UTSW 19 21280524 missense probably damaging 1.00
R1774:Zfand5 UTSW 19 21276531 missense probably damaging 1.00
R4741:Zfand5 UTSW 19 21276481 missense probably damaging 0.99
R4812:Zfand5 UTSW 19 21277737 missense probably benign 0.04
R5117:Zfand5 UTSW 19 21279645 missense probably benign 0.00
R6273:Zfand5 UTSW 19 21279696 missense probably benign 0.02
Posted On2014-05-07