Incidental Mutation 'IGL01905:Apol10b'
| ID |
179643 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Apol10b
|
| Ensembl Gene |
ENSMUSG00000050014 |
| Gene Name |
apolipoprotein L 10B |
| Synonyms |
9130218O11Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01905
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
77468019-77480325 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 77469559 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 206
(I206T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086890
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000089465]
|
| AlphaFold |
G3X9K7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000089465
AA Change: I206T
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000086890
Gene: ENSMUSG00000050014
AA Change: I206T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ApoL
|
28 |
328 |
2.8e-88 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610008E11Rik |
A |
T |
10: 78,903,582 (GRCm39) |
C245S |
probably damaging |
Het |
| Bax |
A |
T |
7: 45,115,542 (GRCm39) |
I31N |
probably damaging |
Het |
| Ccdc116 |
C |
A |
16: 16,960,425 (GRCm39) |
V131L |
probably damaging |
Het |
| Ces2b |
C |
A |
8: 105,560,594 (GRCm39) |
N136K |
probably damaging |
Het |
| Csnk1d |
A |
T |
11: 120,864,789 (GRCm39) |
I65N |
probably damaging |
Het |
| Fam167b |
A |
G |
4: 129,470,892 (GRCm39) |
M152T |
probably damaging |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gm5862 |
A |
C |
5: 26,227,769 (GRCm39) |
W41G |
probably benign |
Het |
| Heatr6 |
C |
T |
11: 83,672,538 (GRCm39) |
S1182L |
probably benign |
Het |
| Lpcat4 |
T |
C |
2: 112,073,388 (GRCm39) |
|
probably null |
Het |
| Myh8 |
T |
C |
11: 67,175,477 (GRCm39) |
Y311H |
possibly damaging |
Het |
| Naaladl1 |
G |
A |
19: 6,165,577 (GRCm39) |
D744N |
possibly damaging |
Het |
| Pik3r4 |
C |
A |
9: 105,522,077 (GRCm39) |
Y214* |
probably null |
Het |
| Proca1 |
A |
G |
11: 78,095,716 (GRCm39) |
H29R |
probably damaging |
Het |
| Prrc2c |
T |
C |
1: 162,532,898 (GRCm39) |
|
probably benign |
Het |
| Rcor3 |
G |
A |
1: 191,785,302 (GRCm39) |
P489S |
probably damaging |
Het |
| Rela |
A |
T |
19: 5,695,592 (GRCm39) |
N337I |
probably benign |
Het |
| Rnf123 |
C |
T |
9: 107,948,569 (GRCm39) |
|
probably benign |
Het |
| Septin9 |
T |
A |
11: 117,109,715 (GRCm39) |
S12T |
probably benign |
Het |
| Serpina1c |
A |
T |
12: 103,863,318 (GRCm39) |
L294Q |
possibly damaging |
Het |
| Slc12a5 |
A |
G |
2: 164,832,301 (GRCm39) |
D740G |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp473 |
T |
C |
7: 44,383,151 (GRCm39) |
K394R |
probably benign |
Het |
| Zkscan7 |
C |
T |
9: 122,719,826 (GRCm39) |
P171S |
possibly damaging |
Het |
| Zmynd19 |
T |
A |
2: 24,841,541 (GRCm39) |
F36L |
probably benign |
Het |
|
| Other mutations in Apol10b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Apol10b
|
APN |
15 |
77,469,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01654:Apol10b
|
APN |
15 |
77,472,996 (GRCm39) |
missense |
probably benign |
|
|
IGL01969:Apol10b
|
APN |
15 |
77,472,885 (GRCm39) |
splice site |
probably null |
|
|
IGL02305:Apol10b
|
APN |
15 |
77,469,630 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0361:Apol10b
|
UTSW |
15 |
77,469,586 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0395:Apol10b
|
UTSW |
15 |
77,469,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0437:Apol10b
|
UTSW |
15 |
77,469,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0502:Apol10b
|
UTSW |
15 |
77,476,349 (GRCm39) |
splice site |
probably benign |
|
|
R0688:Apol10b
|
UTSW |
15 |
77,469,419 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1663:Apol10b
|
UTSW |
15 |
77,472,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1763:Apol10b
|
UTSW |
15 |
77,469,215 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4884:Apol10b
|
UTSW |
15 |
77,473,006 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6177:Apol10b
|
UTSW |
15 |
77,469,987 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7062:Apol10b
|
UTSW |
15 |
77,469,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7480:Apol10b
|
UTSW |
15 |
77,472,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8511:Apol10b
|
UTSW |
15 |
77,469,211 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8511:Apol10b
|
UTSW |
15 |
77,469,210 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8703:Apol10b
|
UTSW |
15 |
77,472,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation