Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01906:Scgb1b24'

179667

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scgb1b24

Ensembl Gene

ENSMUSG00000078753

Gene Name

secretoglobin, family 1B, member 24

Synonyms

Abpa24, Gm12769

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL01906

Quality Score

Status

Chromosome

Chromosomal Location

33443224-33444407 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 33443538 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 66 (C66R)

Ref Sequence

ENSEMBL: ENSMUSP00000103722 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055444] [ENSMUST00000108087]

AlphaFold

B1B0N6

Predicted Effect

probably benign
Transcript: ENSMUST00000055444

SMART Domains

Protein: ENSMUSP00000052456
Gene: ENSMUSG00000046438

Domain	Start	End	E-Value	Type
low complexity region	5	11	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	5.9e-33	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108087
AA Change: C66R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000103722
Gene: ENSMUSG00000078753
AA Change: C66R

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
UTG	23	92	4.95e-15	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,166,225 (GRCm39)	Q24L	probably damaging	Het
Adam1b	A	T	5: 121,639,538 (GRCm39)	N502K	probably benign	Het
Adam6a	T	A	12: 113,507,951 (GRCm39)	M108K	probably benign	Het
Akr1b10	A	G	6: 34,364,746 (GRCm39)	K69R	probably benign	Het
Ap5b1	T	A	19: 5,621,007 (GRCm39)	L809*	probably null	Het
Asxl3	A	T	18: 22,655,338 (GRCm39)	H1116L	probably benign	Het
Birc6	A	G	17: 74,945,353 (GRCm39)	T2794A	probably damaging	Het
Bst1	T	C	5: 43,994,861 (GRCm39)	F248L	probably damaging	Het
Cep120	A	T	18: 53,847,984 (GRCm39)	V625E	probably benign	Het
Cgnl1	T	C	9: 71,631,849 (GRCm39)	M501V	probably benign	Het
Col19a1	T	A	1: 24,356,510 (GRCm39)	D661V	probably damaging	Het
Copb2	A	T	9: 98,462,383 (GRCm39)	E456V	probably benign	Het
Csk	A	G	9: 57,536,304 (GRCm39)	I201T	probably damaging	Het
Cttnbp2	G	T	6: 18,378,375 (GRCm39)	S977*	probably null	Het
Ddr2	A	G	1: 169,809,668 (GRCm39)	W770R	probably damaging	Het
Dnah7b	T	C	1: 46,214,613 (GRCm39)	I1126T	probably damaging	Het
Ephb4	A	T	5: 137,359,456 (GRCm39)	E342V	probably damaging	Het
Erc2	T	A	14: 27,863,263 (GRCm39)	L496Q	probably damaging	Het
Faim2	G	A	15: 99,412,314 (GRCm39)	T140I	probably damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Haus3	A	C	5: 34,325,667 (GRCm39)		probably benign	Het
Hmcn1	T	C	1: 150,543,638 (GRCm39)	T2846A	probably benign	Het
Mto1	T	C	9: 78,372,213 (GRCm39)	V561A	probably benign	Het
Myb	T	C	10: 21,028,533 (GRCm39)	Y110C	probably damaging	Het
Or4k36	T	C	2: 111,146,246 (GRCm39)	C141R	probably damaging	Het
Plcd3	T	C	11: 102,967,682 (GRCm39)	Y420C	probably damaging	Het
Plk4	G	T	3: 40,764,816 (GRCm39)	M603I	probably null	Het
Sec23a	T	C	12: 59,053,830 (GRCm39)	Y56C	probably damaging	Het
Setd1b	C	A	5: 123,295,730 (GRCm39)	D1099E	unknown	Het
Sh2d7	G	A	9: 54,446,750 (GRCm39)		probably benign	Het
Slc30a10	A	T	1: 185,188,593 (GRCm39)	K221*	probably null	Het
Slc5a1	T	C	5: 33,311,997 (GRCm39)	L463P	probably damaging	Het
Sp140l2	A	G	1: 85,231,907 (GRCm39)		probably benign	Het
Strc	T	C	2: 121,208,115 (GRCm39)	T419A	probably benign	Het
Styxl2	A	C	1: 165,927,092 (GRCm39)	L840R	probably damaging	Het
Ttc39a	T	C	4: 109,278,591 (GRCm39)	M82T	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vps13b	T	C	15: 35,639,993 (GRCm39)		probably benign	Het

Other mutations in Scgb1b24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01072:Scgb1b24	APN	7	33,443,434 (GRCm39)	missense	probably damaging	1.00
IGL02268:Scgb1b24	APN	7	33,444,388 (GRCm39)	missense	possibly damaging	0.95
R0268:Scgb1b24	UTSW	7	33,443,278 (GRCm39)	missense	probably null	1.00
R1869:Scgb1b24	UTSW	7	33,443,469 (GRCm39)	missense	probably damaging	0.99
R5229:Scgb1b24	UTSW	7	33,443,520 (GRCm39)	missense	possibly damaging	0.95
R6292:Scgb1b24	UTSW	7	33,443,577 (GRCm39)	missense	possibly damaging	0.90
R7444:Scgb1b24	UTSW	7	33,443,566 (GRCm39)	missense	possibly damaging	0.64
R9428:Scgb1b24	UTSW	7	33,443,493 (GRCm39)	nonsense	probably null

Posted On

2014-05-07