Incidental Mutation 'IGL01908:Vmn1r40'
ID179718
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r40
Ensembl Gene ENSMUSG00000096051
Gene Namevomeronasal 1 receptor 40
SynonymsV1rb7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #IGL01908
Quality Score
Status
Chromosome6
Chromosomal Location89707540-89716657 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 89714303 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Valine at position 34 (A34V)
Ref Sequence ENSEMBL: ENSMUSP00000154581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075158] [ENSMUST00000226925] [ENSMUST00000227669] [ENSMUST00000228485] [ENSMUST00000228642]
Predicted Effect probably benign
Transcript: ENSMUST00000075158
AA Change: A34V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074655
Gene: ENSMUSG00000096051
AA Change: A34V

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 302 3.4e-143 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226925
AA Change: A34V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227669
Predicted Effect probably benign
Transcript: ENSMUST00000228485
Predicted Effect probably benign
Transcript: ENSMUST00000228642
AA Change: A34V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1 G T 6: 48,906,756 R522L probably damaging Het
Asic5 G T 3: 82,006,570 G184* probably null Het
Bcr T A 10: 75,061,873 I283N possibly damaging Het
Bscl2 A G 19: 8,845,276 T134A probably damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Clip1 A G 5: 123,623,207 probably benign Het
Clnk T A 5: 38,713,142 N358Y probably damaging Het
Crnkl1 A T 2: 145,928,155 V256E probably benign Het
Ctsm A T 13: 61,537,787 S270R probably benign Het
Dhx57 G T 17: 80,251,443 P1029H probably damaging Het
Dock3 A G 9: 106,906,662 M277T possibly damaging Het
Fbxo11 T C 17: 87,992,300 K874R probably benign Het
Fyco1 A T 9: 123,829,230 L627Q probably damaging Het
Ghr A T 15: 3,320,447 C416* probably null Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Kif13b T C 14: 64,757,558 C920R probably damaging Het
Lrp1b T C 2: 40,702,804 T3768A probably benign Het
Luzp2 T G 7: 55,172,196 S154A probably damaging Het
Olfr656 A T 7: 104,617,699 T7S probably damaging Het
Pisd C A 5: 32,739,132 probably null Het
Rad51ap2 T A 12: 11,458,591 V838D probably damaging Het
Sbf1 A T 15: 89,302,726 D816E probably damaging Het
Stim1 T C 7: 102,435,650 V603A probably benign Het
Tinagl1 G T 4: 130,167,430 T309K probably damaging Het
Trappc11 G A 8: 47,503,994 A799V probably damaging Het
Vmn1r113 T C 7: 20,788,018 L245P probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Vmn1r40
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Vmn1r40 APN 6 89714596 missense probably damaging 0.99
IGL01432:Vmn1r40 APN 6 89714219 missense probably benign
IGL01777:Vmn1r40 APN 6 89714222 missense probably benign 0.38
IGL01834:Vmn1r40 APN 6 89714572 missense possibly damaging 0.62
IGL01908:Vmn1r40 APN 6 89714309 missense probably damaging 0.97
IGL01999:Vmn1r40 APN 6 89714966 missense probably benign 0.00
IGL02728:Vmn1r40 APN 6 89715016 missense probably benign 0.05
IGL03169:Vmn1r40 APN 6 89715023 missense probably damaging 0.97
R0448:Vmn1r40 UTSW 6 89714660 missense probably benign 0.23
R0971:Vmn1r40 UTSW 6 89714290 missense probably benign 0.00
R1208:Vmn1r40 UTSW 6 89714344 missense probably benign 0.13
R1208:Vmn1r40 UTSW 6 89714344 missense probably benign 0.13
R1448:Vmn1r40 UTSW 6 89714576 missense probably damaging 1.00
R1739:Vmn1r40 UTSW 6 89714315 missense probably benign 0.00
R2170:Vmn1r40 UTSW 6 89714975 missense probably benign 0.11
R3151:Vmn1r40 UTSW 6 89714566 missense probably benign 0.01
R3804:Vmn1r40 UTSW 6 89715009 missense probably benign 0.29
R5098:Vmn1r40 UTSW 6 89714948 missense probably damaging 1.00
R6015:Vmn1r40 UTSW 6 89714606 missense probably damaging 1.00
Posted On2014-05-07