Incidental Mutation 'IGL01913:Tmem151a'
| ID |
179854 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tmem151a
|
| Ensembl Gene |
ENSMUSG00000061451 |
| Gene Name |
transmembrane protein 151A |
| Synonyms |
LOC381199, Gm30627, Tmem151 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.081)
|
| Stock # |
IGL01913
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
5120859-5135519 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 5131920 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 429
(R429C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076321
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077066]
[ENSMUST00000140389]
[ENSMUST00000151413]
|
| AlphaFold |
Q6GQT5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077066
AA Change: R429C
PolyPhen 2
Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000076321
Gene: ENSMUSG00000061451
AA Change: R429C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TMEM151
|
26 |
373 |
8.6e-179 |
PFAM |
|
low complexity region
|
420 |
431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136372
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140389
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151413
|
| SMART Domains |
Protein: ENSMUSP00000121084
Gene: ENSMUSG00000061451
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
48 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acvr2a |
A |
G |
2: 48,789,625 (GRCm39) |
E456G |
probably damaging |
Het |
| Ahnak |
A |
T |
19: 8,983,428 (GRCm39) |
K1571* |
probably null |
Het |
| Arhgef2 |
G |
A |
3: 88,539,226 (GRCm39) |
V58M |
probably damaging |
Het |
| Ash2l |
A |
G |
8: 26,309,652 (GRCm39) |
|
probably null |
Het |
| C3 |
T |
C |
17: 57,520,767 (GRCm39) |
N1163S |
probably null |
Het |
| Cbfa2t2 |
A |
G |
2: 154,359,693 (GRCm39) |
T253A |
probably damaging |
Het |
| Dnah5 |
T |
C |
15: 28,313,899 (GRCm39) |
V1905A |
possibly damaging |
Het |
| Dsg1a |
C |
T |
18: 20,455,293 (GRCm39) |
R86C |
probably damaging |
Het |
| Fastkd1 |
A |
T |
2: 69,538,845 (GRCm39) |
|
probably benign |
Het |
| Fat3 |
T |
C |
9: 15,910,086 (GRCm39) |
D1972G |
probably damaging |
Het |
| Fxyd5 |
T |
C |
7: 30,734,637 (GRCm39) |
T163A |
probably damaging |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| H6pd |
A |
T |
4: 150,078,920 (GRCm39) |
|
probably benign |
Het |
| Klhdc2 |
T |
G |
12: 69,349,132 (GRCm39) |
S90A |
probably benign |
Het |
| Lcn2 |
A |
G |
2: 32,277,157 (GRCm39) |
V139A |
possibly damaging |
Het |
| Nup205 |
A |
G |
6: 35,204,365 (GRCm39) |
E1417G |
probably benign |
Het |
| Or4a77 |
T |
G |
2: 89,487,684 (GRCm39) |
I34L |
probably benign |
Het |
| Or5ac25 |
A |
T |
16: 59,182,294 (GRCm39) |
C96S |
probably damaging |
Het |
| Or5t17 |
A |
T |
2: 86,833,164 (GRCm39) |
M284L |
possibly damaging |
Het |
| Pcdh18 |
C |
A |
3: 49,709,698 (GRCm39) |
S539I |
possibly damaging |
Het |
| Stat1 |
T |
C |
1: 52,165,716 (GRCm39) |
I104T |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Wdpcp |
A |
G |
11: 21,698,931 (GRCm39) |
D570G |
probably damaging |
Het |
| Zbtb47 |
T |
C |
9: 121,593,035 (GRCm39) |
C452R |
probably damaging |
Het |
| Zfp429 |
T |
C |
13: 67,544,793 (GRCm39) |
Y27C |
probably damaging |
Het |
| Zfp462 |
T |
C |
4: 55,012,138 (GRCm39) |
V1368A |
probably benign |
Het |
|
| Other mutations in Tmem151a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02708:Tmem151a
|
APN |
19 |
5,132,875 (GRCm39) |
nonsense |
probably null |
|
|
IGL02887:Tmem151a
|
APN |
19 |
5,132,993 (GRCm39) |
missense |
probably benign |
|
|
IGL03144:Tmem151a
|
APN |
19 |
5,135,400 (GRCm39) |
start codon destroyed |
probably benign |
0.01 |
|
R0395:Tmem151a
|
UTSW |
19 |
5,132,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Tmem151a
|
UTSW |
19 |
5,132,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Tmem151a
|
UTSW |
19 |
5,132,966 (GRCm39) |
missense |
probably benign |
|
|
R4399:Tmem151a
|
UTSW |
19 |
5,133,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4612:Tmem151a
|
UTSW |
19 |
5,121,862 (GRCm39) |
unclassified |
probably benign |
|
|
R5171:Tmem151a
|
UTSW |
19 |
5,132,061 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6921:Tmem151a
|
UTSW |
19 |
5,133,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7205:Tmem151a
|
UTSW |
19 |
5,132,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7413:Tmem151a
|
UTSW |
19 |
5,132,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7544:Tmem151a
|
UTSW |
19 |
5,121,895 (GRCm39) |
missense |
unknown |
|
|
R8017:Tmem151a
|
UTSW |
19 |
5,132,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9662:Tmem151a
|
UTSW |
19 |
5,132,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9709:Tmem151a
|
UTSW |
19 |
5,131,876 (GRCm39) |
nonsense |
probably null |
|
|
R9732:Tmem151a
|
UTSW |
19 |
5,131,937 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9786:Tmem151a
|
UTSW |
19 |
5,131,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tmem151a
|
UTSW |
19 |
5,133,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation