Incidental Mutation 'IGL01913:Fastkd1'
ID179872
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fastkd1
Ensembl Gene ENSMUSG00000027086
Gene NameFAST kinase domains 1
Synonyms5330408N05Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.386) question?
Stock #IGL01913
Quality Score
Status
Chromosome2
Chromosomal Location69686815-69713516 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 69708501 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000099767 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073152] [ENSMUST00000102706]
Predicted Effect probably benign
Transcript: ENSMUST00000073152
SMART Domains Protein: ENSMUSP00000072896
Gene: ENSMUSG00000027086

DomainStartEndE-ValueType
low complexity region 179 191 N/A INTRINSIC
low complexity region 316 324 N/A INTRINSIC
low complexity region 385 396 N/A INTRINSIC
low complexity region 461 472 N/A INTRINSIC
Pfam:FAST_1 560 628 6.6e-25 PFAM
Pfam:FAST_2 645 730 6.4e-26 PFAM
RAP 763 822 4.38e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102706
SMART Domains Protein: ENSMUSP00000099767
Gene: ENSMUSG00000027086

DomainStartEndE-ValueType
low complexity region 179 191 N/A INTRINSIC
low complexity region 316 324 N/A INTRINSIC
low complexity region 385 396 N/A INTRINSIC
low complexity region 461 472 N/A INTRINSIC
Pfam:FAST_1 530 600 2.2e-26 PFAM
Pfam:FAST_2 614 701 4.4e-31 PFAM
RAP 734 793 4.38e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129260
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140776
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr2a A G 2: 48,899,613 E456G probably damaging Het
Ahnak A T 19: 9,006,064 K1571* probably null Het
Arhgef2 G A 3: 88,631,919 V58M probably damaging Het
Ash2l A G 8: 25,819,624 probably null Het
C3 T C 17: 57,213,767 N1163S probably null Het
Cbfa2t2 A G 2: 154,517,773 T253A probably damaging Het
Dnah5 T C 15: 28,313,753 V1905A possibly damaging Het
Dsg1a C T 18: 20,322,236 R86C probably damaging Het
Fat3 T C 9: 15,998,790 D1972G probably damaging Het
Fxyd5 T C 7: 31,035,212 T163A probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
H6pd A T 4: 149,994,463 probably benign Het
Klhdc2 T G 12: 69,302,358 S90A probably benign Het
Lcn2 A G 2: 32,387,145 V139A possibly damaging Het
Nup205 A G 6: 35,227,430 E1417G probably benign Het
Olfr1102 A T 2: 87,002,820 M284L possibly damaging Het
Olfr1250 T G 2: 89,657,340 I34L probably benign Het
Olfr209 A T 16: 59,361,931 C96S probably damaging Het
Pcdh18 C A 3: 49,755,249 S539I possibly damaging Het
Stat1 T C 1: 52,126,557 I104T probably benign Het
Tmem151a G A 19: 5,081,892 R429C probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Wdpcp A G 11: 21,748,931 D570G probably damaging Het
Zfp429 T C 13: 67,396,674 Y27C probably damaging Het
Zfp462 T C 4: 55,012,138 V1368A probably benign Het
Zfp651 T C 9: 121,763,969 C452R probably damaging Het
Other mutations in Fastkd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Fastkd1 APN 2 69707549 missense probably benign 0.02
IGL00702:Fastkd1 APN 2 69708545 missense probably damaging 0.99
IGL00960:Fastkd1 APN 2 69694653 splice site probably benign
IGL01154:Fastkd1 APN 2 69690060 splice site probably null
IGL01463:Fastkd1 APN 2 69690061 critical splice donor site probably null
IGL01977:Fastkd1 APN 2 69694588 missense possibly damaging 0.64
IGL02408:Fastkd1 APN 2 69702601 missense probably benign
IGL02715:Fastkd1 APN 2 69712125 critical splice donor site probably null
IGL03411:Fastkd1 APN 2 69707359 missense probably damaging 0.99
R0541:Fastkd1 UTSW 2 69702406 missense probably damaging 1.00
R0612:Fastkd1 UTSW 2 69712383 missense probably benign 0.03
R1170:Fastkd1 UTSW 2 69708649 splice site probably benign
R1499:Fastkd1 UTSW 2 69708638 critical splice acceptor site probably null
R1586:Fastkd1 UTSW 2 69712148 missense probably benign 0.43
R1698:Fastkd1 UTSW 2 69702469 missense probably benign 0.22
R2172:Fastkd1 UTSW 2 69700133 missense probably damaging 1.00
R2240:Fastkd1 UTSW 2 69696953 missense probably benign 0.01
R2327:Fastkd1 UTSW 2 69705528 nonsense probably null
R2897:Fastkd1 UTSW 2 69702616 missense probably damaging 1.00
R4120:Fastkd1 UTSW 2 69707310 missense probably damaging 0.98
R4544:Fastkd1 UTSW 2 69712311 missense probably damaging 1.00
R4546:Fastkd1 UTSW 2 69712311 missense probably damaging 1.00
R4798:Fastkd1 UTSW 2 69691307 missense probably benign 0.38
R4993:Fastkd1 UTSW 2 69702740 missense probably damaging 0.99
R5284:Fastkd1 UTSW 2 69712188 missense probably benign 0.01
R5668:Fastkd1 UTSW 2 69707381 missense possibly damaging 0.92
R6869:Fastkd1 UTSW 2 69702760 missense probably benign 0.02
R6870:Fastkd1 UTSW 2 69708614 missense probably benign 0.05
R7062:Fastkd1 UTSW 2 69704322 missense possibly damaging 0.74
Posted On2014-05-07