Incidental Mutation 'IGL01919:Rgs16'
ID 180039
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rgs16
Ensembl Gene ENSMUSG00000026475
Gene Name regulator of G-protein signaling 16
Synonyms Rgsr
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # IGL01919
Quality Score
Status
Chromosome 1
Chromosomal Location 153616099-153621212 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 153617804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 105 (S105T)
Ref Sequence ENSEMBL: ENSMUSP00000027748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027748]
AlphaFold P97428
PDB Structure Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000027748
AA Change: S105T

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000027748
Gene: ENSMUSG00000026475
AA Change: S105T

DomainStartEndE-ValueType
RGS 64 180 3.69e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190663
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191474
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility toparasitic infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,608,580 (GRCm39) probably null Het
Alms1 T C 6: 85,604,986 (GRCm39) F2212S possibly damaging Het
Anpep T C 7: 79,475,098 (GRCm39) I155V possibly damaging Het
Aoc1 G A 6: 48,885,223 (GRCm39) V653M probably damaging Het
Arl8b T C 6: 108,798,518 (GRCm39) probably benign Het
Bax A C 7: 45,115,552 (GRCm39) probably null Het
Cpne7 G A 8: 123,852,382 (GRCm39) E195K probably damaging Het
Csmd3 A G 15: 47,539,168 (GRCm39) I2330T possibly damaging Het
Dnajc16 A G 4: 141,501,940 (GRCm39) S297P probably benign Het
Farp2 A G 1: 93,504,155 (GRCm39) K311E probably damaging Het
Fhad1 A G 4: 141,691,906 (GRCm39) L410P probably damaging Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm12185 T C 11: 48,798,886 (GRCm39) T536A possibly damaging Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Hydin C T 8: 111,245,806 (GRCm39) T2173I possibly damaging Het
Kpnb1 A G 11: 97,055,556 (GRCm39) V783A probably benign Het
Krt1 A G 15: 101,754,811 (GRCm39) V509A unknown Het
Lrwd1 A T 5: 136,164,729 (GRCm39) L26* probably null Het
Mal2 T A 15: 54,451,728 (GRCm39) W50R probably damaging Het
Map3k21 A T 8: 126,668,871 (GRCm39) E819V probably damaging Het
Mrgprx3-ps T C 7: 46,959,959 (GRCm39) T11A probably benign Het
Mroh2b T C 15: 4,953,170 (GRCm39) F635L probably benign Het
Mylip G A 13: 45,562,178 (GRCm39) E327K probably damaging Het
Nfix T C 8: 85,453,103 (GRCm39) D308G probably damaging Het
Or1l8 G A 2: 36,817,824 (GRCm39) Q101* probably null Het
Or7e166 G A 9: 19,624,638 (GRCm39) V172I probably benign Het
Psma6 A G 12: 55,454,254 (GRCm39) E26G probably damaging Het
Slc25a23 T A 17: 57,354,291 (GRCm39) N372Y possibly damaging Het
Slc35e2 A G 4: 155,697,187 (GRCm39) M234V probably benign Het
Tbc1d8 A G 1: 39,431,334 (GRCm39) V346A probably damaging Het
Tgfb1i1 C T 7: 127,847,654 (GRCm39) probably benign Het
Triml2 A C 8: 43,643,349 (GRCm39) T177P probably damaging Het
Uba6 T C 5: 86,267,245 (GRCm39) T959A probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Rgs16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02319:Rgs16 APN 1 153,617,852 (GRCm39) missense probably damaging 1.00
LCD18:Rgs16 UTSW 1 153,619,976 (GRCm39) utr 3 prime probably benign
R0295:Rgs16 UTSW 1 153,619,483 (GRCm39) missense probably damaging 1.00
R1355:Rgs16 UTSW 1 153,619,414 (GRCm39) missense probably damaging 0.99
R4639:Rgs16 UTSW 1 153,617,781 (GRCm39) missense probably damaging 1.00
R5398:Rgs16 UTSW 1 153,616,246 (GRCm39) missense probably benign 0.01
R6566:Rgs16 UTSW 1 153,619,546 (GRCm39) missense unknown
R6629:Rgs16 UTSW 1 153,619,420 (GRCm39) missense probably damaging 0.98
R7208:Rgs16 UTSW 1 153,617,416 (GRCm39) missense probably damaging 1.00
R8195:Rgs16 UTSW 1 153,616,689 (GRCm39) missense probably benign 0.00
R9125:Rgs16 UTSW 1 153,617,874 (GRCm39) missense probably null 1.00
R9140:Rgs16 UTSW 1 153,619,381 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07