Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01919:Mrgprx3-ps'

180048

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprx3-ps

Ensembl Gene

ENSMUSG00000099560

Gene Name

MAS-related GPR, member X3, pseudogene

Synonyms

LOC269919, Gm660, Gm19419

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.238) question?

Stock #

IGL01919

Quality Score

Status

Chromosome

Chromosomal Location

46959126-46960043 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 46959959 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 11 (T11A)

Ref Sequence

ENSEMBL: ENSMUSP00000136396 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179005]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000179005
AA Change: T11A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: T11A

Domain	Start	End	E-Value	Type
Pfam:7tm_1	12	178	3.4e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187741

Meta Mutation Damage Score

0.0898

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700062C07Rik	A	G	18: 24,608,580 (GRCm39)		probably null	Het
Alms1	T	C	6: 85,604,986 (GRCm39)	F2212S	possibly damaging	Het
Anpep	T	C	7: 79,475,098 (GRCm39)	I155V	possibly damaging	Het
Aoc1	G	A	6: 48,885,223 (GRCm39)	V653M	probably damaging	Het
Arl8b	T	C	6: 108,798,518 (GRCm39)		probably benign	Het
Bax	A	C	7: 45,115,552 (GRCm39)		probably null	Het
Cpne7	G	A	8: 123,852,382 (GRCm39)	E195K	probably damaging	Het
Csmd3	A	G	15: 47,539,168 (GRCm39)	I2330T	possibly damaging	Het
Dnajc16	A	G	4: 141,501,940 (GRCm39)	S297P	probably benign	Het
Farp2	A	G	1: 93,504,155 (GRCm39)	K311E	probably damaging	Het
Fhad1	A	G	4: 141,691,906 (GRCm39)	L410P	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm12185	T	C	11: 48,798,886 (GRCm39)	T536A	possibly damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Hydin	C	T	8: 111,245,806 (GRCm39)	T2173I	possibly damaging	Het
Kpnb1	A	G	11: 97,055,556 (GRCm39)	V783A	probably benign	Het
Krt1	A	G	15: 101,754,811 (GRCm39)	V509A	unknown	Het
Lrwd1	A	T	5: 136,164,729 (GRCm39)	L26*	probably null	Het
Mal2	T	A	15: 54,451,728 (GRCm39)	W50R	probably damaging	Het
Map3k21	A	T	8: 126,668,871 (GRCm39)	E819V	probably damaging	Het
Mroh2b	T	C	15: 4,953,170 (GRCm39)	F635L	probably benign	Het
Mylip	G	A	13: 45,562,178 (GRCm39)	E327K	probably damaging	Het
Nfix	T	C	8: 85,453,103 (GRCm39)	D308G	probably damaging	Het
Or1l8	G	A	2: 36,817,824 (GRCm39)	Q101*	probably null	Het
Or7e166	G	A	9: 19,624,638 (GRCm39)	V172I	probably benign	Het
Psma6	A	G	12: 55,454,254 (GRCm39)	E26G	probably damaging	Het
Rgs16	T	A	1: 153,617,804 (GRCm39)	S105T	probably damaging	Het
Slc25a23	T	A	17: 57,354,291 (GRCm39)	N372Y	possibly damaging	Het
Slc35e2	A	G	4: 155,697,187 (GRCm39)	M234V	probably benign	Het
Tbc1d8	A	G	1: 39,431,334 (GRCm39)	V346A	probably damaging	Het
Tgfb1i1	C	T	7: 127,847,654 (GRCm39)		probably benign	Het
Triml2	A	C	8: 43,643,349 (GRCm39)	T177P	probably damaging	Het
Uba6	T	C	5: 86,267,245 (GRCm39)	T959A	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het

Other mutations in Mrgprx3-ps

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01629:Mrgprx3-ps	APN	7	46,959,353 (GRCm39)	nonsense	probably null	0.00
IGL02455:Mrgprx3-ps	APN	7	46,959,263 (GRCm39)	exon	noncoding transcript
R0218:Mrgprx3-ps	UTSW	7	46,959,154 (GRCm39)	missense	possibly damaging	0.87
R0308:Mrgprx3-ps	UTSW	7	46,959,766 (GRCm39)	missense	probably benign	0.25
R4003:Mrgprx3-ps	UTSW	7	46,959,959 (GRCm39)	missense	probably benign	0.00
R4274:Mrgprx3-ps	UTSW	7	46,959,574 (GRCm39)	exon	noncoding transcript
R4411:Mrgprx3-ps	UTSW	7	46,959,746 (GRCm39)	exon	noncoding transcript
R4413:Mrgprx3-ps	UTSW	7	46,959,746 (GRCm39)	exon	noncoding transcript
R5254:Mrgprx3-ps	UTSW	7	46,959,184 (GRCm39)	exon	noncoding transcript

Posted On

2014-05-07