Incidental Mutation 'IGL01919:Olfr355'
ID180055
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr355
Ensembl Gene ENSMUSG00000075380
Gene Nameolfactory receptor 355
SynonymsMOR138-2, GA_x6K02T2NLDC-33622642-33621710
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.281) question?
Stock #IGL01919
Quality Score
Status
Chromosome2
Chromosomal Location36925190-36928897 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 36927812 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 101 (Q101*)
Ref Sequence ENSEMBL: ENSMUSP00000151206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100147] [ENSMUST00000213574]
Predicted Effect probably null
Transcript: ENSMUST00000100147
AA Change: Q101*
SMART Domains Protein: ENSMUSP00000097725
Gene: ENSMUSG00000075380
AA Change: Q101*

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.9e-55 PFAM
Pfam:7tm_1 42 290 2.2e-26 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213574
AA Change: Q101*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,475,523 probably null Het
Alms1 T C 6: 85,628,004 F2212S possibly damaging Het
Anpep T C 7: 79,825,350 I155V possibly damaging Het
Aoc1 G A 6: 48,908,289 V653M probably damaging Het
Arl8b T C 6: 108,821,557 probably benign Het
Bax A C 7: 45,466,128 probably null Het
Cpne7 G A 8: 123,125,643 E195K probably damaging Het
Csmd3 A G 15: 47,675,772 I2330T possibly damaging Het
Dnajc16 A G 4: 141,774,629 S297P probably benign Het
Farp2 A G 1: 93,576,433 K311E probably damaging Het
Fhad1 A G 4: 141,964,595 L410P probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm12185 T C 11: 48,908,059 T536A possibly damaging Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hydin C T 8: 110,519,174 T2173I possibly damaging Het
Kpnb1 A G 11: 97,164,730 V783A probably benign Het
Krt1 A G 15: 101,846,376 V509A unknown Het
Lrwd1 A T 5: 136,135,875 L26* probably null Het
Mal2 T A 15: 54,588,332 W50R probably damaging Het
Map3k21 A T 8: 125,942,132 E819V probably damaging Het
Mrgprx3-ps T C 7: 47,310,211 T11A probably benign Het
Mroh2b T C 15: 4,923,688 F635L probably benign Het
Mylip G A 13: 45,408,702 E327K probably damaging Het
Nfix T C 8: 84,726,474 D308G probably damaging Het
Olfr857 G A 9: 19,713,342 V172I probably benign Het
Psma6 A G 12: 55,407,469 E26G probably damaging Het
Rgs16 T A 1: 153,742,058 S105T probably damaging Het
Slc25a23 T A 17: 57,047,291 N372Y possibly damaging Het
Slc35e2 A G 4: 155,612,730 M234V probably benign Het
Tbc1d8 A G 1: 39,392,253 V346A probably damaging Het
Tgfb1i1 C T 7: 128,248,482 probably benign Het
Triml2 A C 8: 43,190,312 T177P probably damaging Het
Uba6 T C 5: 86,119,386 T959A probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Olfr355
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02523:Olfr355 APN 2 36927955 missense probably damaging 0.99
IGL03050:Olfr355 UTSW 2 36927808 missense probably damaging 0.99
R0458:Olfr355 UTSW 2 36927337 missense probably damaging 1.00
R1019:Olfr355 UTSW 2 36927752 missense probably benign 0.00
R1115:Olfr355 UTSW 2 36927502 missense possibly damaging 0.72
R1460:Olfr355 UTSW 2 36927808 missense probably damaging 0.99
R1663:Olfr355 UTSW 2 36927334 missense probably damaging 1.00
R1902:Olfr355 UTSW 2 36927185 missense probably benign 0.00
R2964:Olfr355 UTSW 2 36927407 missense probably benign 0.00
R4751:Olfr355 UTSW 2 36927583 missense probably damaging 1.00
R4884:Olfr355 UTSW 2 36928012 missense possibly damaging 0.65
R4935:Olfr355 UTSW 2 36927701 missense probably benign 0.05
R6114:Olfr355 UTSW 2 36927689 missense possibly damaging 0.93
R6184:Olfr355 UTSW 2 36927392 missense probably damaging 1.00
R6476:Olfr355 UTSW 2 36927583 missense possibly damaging 0.75
X0025:Olfr355 UTSW 2 36927950 missense probably benign 0.33
Posted On2014-05-07