Incidental Mutation 'IGL01919:Arl8b'
ID180061
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arl8b
Ensembl Gene ENSMUSG00000030105
Gene NameADP-ribosylation factor-like 8B
Synonyms3100002J04Rik, 2610313E07Rik, Arl10c
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.210) question?
Stock #IGL01919
Quality Score
Status
Chromosome6
Chromosomal Location108783099-108825278 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to C at 108821557 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032196] [ENSMUST00000204483]
Predicted Effect probably benign
Transcript: ENSMUST00000032196
SMART Domains Protein: ENSMUSP00000032196
Gene: ENSMUSG00000030105

DomainStartEndE-ValueType
ARF 1 185 4.46e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000204483
SMART Domains Protein: ENSMUSP00000145035
Gene: ENSMUSG00000030105

DomainStartEndE-ValueType
small_GTPase 2 136 3.8e-7 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display perinatal lethality with impaired visceral yolk sac function and reduced embryo size. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,475,523 probably null Het
Alms1 T C 6: 85,628,004 F2212S possibly damaging Het
Anpep T C 7: 79,825,350 I155V possibly damaging Het
Aoc1 G A 6: 48,908,289 V653M probably damaging Het
Bax A C 7: 45,466,128 probably null Het
Cpne7 G A 8: 123,125,643 E195K probably damaging Het
Csmd3 A G 15: 47,675,772 I2330T possibly damaging Het
Dnajc16 A G 4: 141,774,629 S297P probably benign Het
Farp2 A G 1: 93,576,433 K311E probably damaging Het
Fhad1 A G 4: 141,964,595 L410P probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm12185 T C 11: 48,908,059 T536A possibly damaging Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hydin C T 8: 110,519,174 T2173I possibly damaging Het
Kpnb1 A G 11: 97,164,730 V783A probably benign Het
Krt1 A G 15: 101,846,376 V509A unknown Het
Lrwd1 A T 5: 136,135,875 L26* probably null Het
Mal2 T A 15: 54,588,332 W50R probably damaging Het
Map3k21 A T 8: 125,942,132 E819V probably damaging Het
Mrgprx3-ps T C 7: 47,310,211 T11A probably benign Het
Mroh2b T C 15: 4,923,688 F635L probably benign Het
Mylip G A 13: 45,408,702 E327K probably damaging Het
Nfix T C 8: 84,726,474 D308G probably damaging Het
Olfr355 G A 2: 36,927,812 Q101* probably null Het
Olfr857 G A 9: 19,713,342 V172I probably benign Het
Psma6 A G 12: 55,407,469 E26G probably damaging Het
Rgs16 T A 1: 153,742,058 S105T probably damaging Het
Slc25a23 T A 17: 57,047,291 N372Y possibly damaging Het
Slc35e2 A G 4: 155,612,730 M234V probably benign Het
Tbc1d8 A G 1: 39,392,253 V346A probably damaging Het
Tgfb1i1 C T 7: 128,248,482 probably benign Het
Triml2 A C 8: 43,190,312 T177P probably damaging Het
Uba6 T C 5: 86,119,386 T959A probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Arl8b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03135:Arl8b APN 6 108818545 missense probably benign 0.10
R0486:Arl8b UTSW 6 108815326 missense possibly damaging 0.84
R0544:Arl8b UTSW 6 108783228 start gained probably benign
R1018:Arl8b UTSW 6 108818611 missense probably damaging 0.98
R2248:Arl8b UTSW 6 108783343 missense probably benign 0.00
R2351:Arl8b UTSW 6 108821523 missense possibly damaging 0.84
R3815:Arl8b UTSW 6 108813697 missense probably damaging 1.00
R3816:Arl8b UTSW 6 108813697 missense probably damaging 1.00
R5538:Arl8b UTSW 6 108783336 missense probably damaging 1.00
R6480:Arl8b UTSW 6 108815049 missense possibly damaging 0.79
R7147:Arl8b UTSW 6 108815015 missense not run
Posted On2014-05-07