Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01922:Or2t46'

180125

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2t46

Ensembl Gene

ENSMUSG00000060765

Gene Name

olfactory receptor family 2 subfamily T member 46

Synonyms

MOR275-11_p, Olfr325, GA_x6K02T2NKPP-844642-843680, MOR275-5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01922

Quality Score

Status

Chromosome

Chromosomal Location

58471663-58472703 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 58471899 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 76 (M76I)

Ref Sequence

ENSEMBL: ENSMUSP00000145386 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]

AlphaFold

Q5NCD2

Predicted Effect

probably benign
Transcript: ENSMUST00000169428
AA Change: M76I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: M76I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	312	2.3e-46	PFAM
Pfam:7TM_GPCR_Srsx	39	290	1.4e-6	PFAM
Pfam:7tm_1	45	294	1.6e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203418
AA Change: M76I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: M76I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	130	7.6e-14	PFAM
Pfam:7TM_GPCR_Srsx	36	130	1.1e-4	PFAM
Pfam:7tm_1	45	130	2.6e-16	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam12	C	A	7: 133,539,201 (GRCm39)	G104*	probably null	Het
Adamtsl1	A	G	4: 86,168,139 (GRCm39)	K477R	probably damaging	Het
Arhgap35	A	C	7: 16,298,180 (GRCm39)	V295G	possibly damaging	Het
Cacna1c	A	T	6: 118,629,629 (GRCm39)	I1234N	probably damaging	Het
Cntnap5c	A	G	17: 58,637,114 (GRCm39)	E997G	possibly damaging	Het
Cog6	T	C	3: 52,893,846 (GRCm39)	N601S	probably benign	Het
Col28a1	G	T	6: 8,158,133 (GRCm39)	D308E	probably damaging	Het
Cplane1	A	G	15: 8,300,305 (GRCm39)	K3204R	unknown	Het
Cspg4	G	A	9: 56,795,171 (GRCm39)	D969N	probably damaging	Het
Dhx8	G	A	11: 101,630,633 (GRCm39)	V347I	probably damaging	Het
Dnah9	G	T	11: 65,965,860 (GRCm39)		probably benign	Het
Erap1	T	C	13: 74,810,506 (GRCm39)	Y282H	probably damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
H2-T3	A	G	17: 36,497,992 (GRCm39)	M307T	possibly damaging	Het
Ifi204	T	C	1: 173,589,288 (GRCm39)	I48V	possibly damaging	Het
Myh1	T	C	11: 67,101,292 (GRCm39)		probably null	Het
Nphp1	T	C	2: 127,621,989 (GRCm39)	Y46C	possibly damaging	Het
Odad3	G	T	9: 21,904,826 (GRCm39)		probably benign	Het
Or14j7	A	T	17: 38,234,850 (GRCm39)	H131L	possibly damaging	Het
Piezo1	G	T	8: 123,219,431 (GRCm39)	S1066R	probably benign	Het
Plekhh1	T	C	12: 79,126,353 (GRCm39)	S1353P	probably benign	Het
Prl6a1	A	T	13: 27,499,343 (GRCm39)	D37V	possibly damaging	Het
Scn4a	A	G	11: 106,229,978 (GRCm39)		probably null	Het
Selenoo	T	C	15: 88,983,852 (GRCm39)	V585A	probably benign	Het
Tmf1	T	C	6: 97,153,891 (GRCm39)	T61A	probably benign	Het
Tshz3	A	G	7: 36,469,030 (GRCm39)	T340A	probably damaging	Het
Unc50	A	G	1: 37,476,284 (GRCm39)	D148G	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Xpc	C	T	6: 91,482,407 (GRCm39)	R192H	probably damaging	Het

Other mutations in Or2t46

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00953:Or2t46	APN	11	58,472,636 (GRCm39)	missense	probably benign
IGL02440:Or2t46	APN	11	58,472,035 (GRCm39)	missense	probably damaging	1.00
IGL02456:Or2t46	APN	11	58,472,024 (GRCm39)	missense	possibly damaging	0.48
IGL03088:Or2t46	APN	11	58,472,653 (GRCm39)	utr 3 prime	probably benign
IGL03328:Or2t46	APN	11	58,472,539 (GRCm39)	missense	probably damaging	1.00
R0604:Or2t46	UTSW	11	58,472,174 (GRCm39)	missense	probably damaging	0.99
R1698:Or2t46	UTSW	11	58,472,077 (GRCm39)	missense	probably damaging	1.00
R2473:Or2t46	UTSW	11	58,472,401 (GRCm39)	missense	probably damaging	1.00
R2888:Or2t46	UTSW	11	58,471,988 (GRCm39)	missense	possibly damaging	0.96
R4133:Or2t46	UTSW	11	58,471,901 (GRCm39)	missense	probably damaging	0.97
R4710:Or2t46	UTSW	11	58,472,548 (GRCm39)	missense	probably damaging	1.00
R4715:Or2t46	UTSW	11	58,472,255 (GRCm39)	missense	probably damaging	1.00
R4898:Or2t46	UTSW	11	58,472,546 (GRCm39)	missense	probably damaging	1.00
R4939:Or2t46	UTSW	11	58,472,037 (GRCm39)	missense	probably damaging	1.00
R4977:Or2t46	UTSW	11	58,472,455 (GRCm39)	missense	possibly damaging	0.57
R5389:Or2t46	UTSW	11	58,471,825 (GRCm39)	missense	possibly damaging	0.78
R5393:Or2t46	UTSW	11	58,471,825 (GRCm39)	missense	possibly damaging	0.78
R6137:Or2t46	UTSW	11	58,471,894 (GRCm39)	missense	probably benign
R6302:Or2t46	UTSW	11	58,472,464 (GRCm39)	missense	probably benign
R6655:Or2t46	UTSW	11	58,472,036 (GRCm39)	missense	probably damaging	1.00
R6927:Or2t46	UTSW	11	58,472,491 (GRCm39)	missense	possibly damaging	0.81
R7451:Or2t46	UTSW	11	58,472,516 (GRCm39)	missense	probably damaging	1.00
R7494:Or2t46	UTSW	11	58,472,038 (GRCm39)	missense	probably damaging	0.97
R7626:Or2t46	UTSW	11	58,471,999 (GRCm39)	missense	probably damaging	0.97
R7724:Or2t46	UTSW	11	58,472,208 (GRCm39)	missense	probably benign	0.01
R7874:Or2t46	UTSW	11	58,472,573 (GRCm39)	missense	possibly damaging	0.93
R8217:Or2t46	UTSW	11	58,471,792 (GRCm39)	missense	probably benign	0.00
R8252:Or2t46	UTSW	11	58,471,958 (GRCm39)	missense	probably damaging	1.00
R8992:Or2t46	UTSW	11	58,471,738 (GRCm39)	missense	probably benign	0.00
R9376:Or2t46	UTSW	11	58,472,636 (GRCm39)	missense	probably benign
R9439:Or2t46	UTSW	11	58,472,104 (GRCm39)	missense	probably benign	0.38
Z1177:Or2t46	UTSW	11	58,472,137 (GRCm39)	missense	probably damaging	1.00
Z1186:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1186:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1187:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1188:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1189:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1190:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1191:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1192:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign

Posted On

2014-05-07