Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01925:Yeats2'

180281

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Yeats2

Ensembl Gene

ENSMUSG00000041215

Gene Name

YEATS domain containing 2

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.964) question?

Stock #

IGL01925

Quality Score

Status

Chromosome

Chromosomal Location

19959813-20051323 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 19998430 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000155891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]

AlphaFold

Q3TUF7

Predicted Effect

probably benign
Transcript: ENSMUST00000090052

SMART Domains

Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215

Domain	Start	End	E-Value	Type
Pfam:YEATS	179	262	2.6e-27	PFAM
low complexity region	299	309	N/A	INTRINSIC
low complexity region	312	333	N/A	INTRINSIC
low complexity region	409	429	N/A	INTRINSIC
low complexity region	458	467	N/A	INTRINSIC
internal_repeat_1	471	675	3.72e-6	PROSPERO
low complexity region	683	702	N/A	INTRINSIC
low complexity region	738	775	N/A	INTRINSIC
internal_repeat_1	785	978	3.72e-6	PROSPERO
low complexity region	1240	1249	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115560

SMART Domains

Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215

Domain	Start	End	E-Value	Type
Pfam:YEATS	232	314	2.1e-28	PFAM
low complexity region	352	362	N/A	INTRINSIC
low complexity region	365	386	N/A	INTRINSIC
low complexity region	462	482	N/A	INTRINSIC
low complexity region	511	520	N/A	INTRINSIC
internal_repeat_1	524	728	4.68e-6	PROSPERO
low complexity region	736	755	N/A	INTRINSIC
low complexity region	791	828	N/A	INTRINSIC
internal_repeat_1	838	1031	4.68e-6	PROSPERO
low complexity region	1293	1302	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117664

Predicted Effect

probably benign
Transcript: ENSMUST00000232019

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232172

Predicted Effect

probably benign
Transcript: ENSMUST00000232338

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aloxe3	A	G	11: 69,019,459 (GRCm39)	D124G	probably damaging	Het
Arap3	C	T	18: 38,117,299 (GRCm39)	V926I	probably benign	Het
Catspere2	T	A	1: 177,842,687 (GRCm39)		probably benign	Het
Col6a3	C	T	1: 90,729,958 (GRCm39)	V1176M	possibly damaging	Het
D5Ertd579e	A	T	5: 36,771,628 (GRCm39)	D922E	possibly damaging	Het
Dipk2a	A	C	9: 94,402,509 (GRCm39)	D384E	probably damaging	Het
Epm2a	T	A	10: 11,324,502 (GRCm39)	I197N	possibly damaging	Het
Faim	T	G	9: 98,872,972 (GRCm39)		probably benign	Het
Fkbp15	A	G	4: 62,241,450 (GRCm39)	I565T	probably damaging	Het
Fli1	G	A	9: 32,377,127 (GRCm39)	P47L	probably damaging	Het
Gli2	T	C	1: 118,781,106 (GRCm39)	K187R	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Hspa5	G	A	2: 34,664,730 (GRCm39)	V395I	probably benign	Het
Ide	T	C	19: 37,255,296 (GRCm39)	T836A	unknown	Het
Il9	T	A	13: 56,629,684 (GRCm39)		probably benign	Het
Ints8	C	T	4: 11,235,617 (GRCm39)		probably benign	Het
Lrrc37a	T	A	11: 103,389,245 (GRCm39)	H2060L	probably benign	Het
Mok	T	C	12: 110,774,646 (GRCm39)	N208S	probably benign	Het
Morn3	T	C	5: 123,184,825 (GRCm39)	K5R	probably damaging	Het
Nalcn	C	T	14: 123,529,260 (GRCm39)	C1405Y	possibly damaging	Het
Ndufv3	T	C	17: 31,746,460 (GRCm39)	S117P	possibly damaging	Het
Ninl	A	T	2: 150,812,979 (GRCm39)	C226S	probably damaging	Het
Onecut2	T	C	18: 64,474,585 (GRCm39)	W360R	probably damaging	Het
Or10al4	A	G	17: 38,037,002 (GRCm39)	E29G	probably benign	Het
Or13f5	A	G	4: 52,825,910 (GRCm39)	N171S	probably benign	Het
Or1af1	A	G	2: 37,110,058 (GRCm39)	T186A	probably benign	Het
Or2d3b	T	A	7: 106,514,235 (GRCm39)	F277I	probably damaging	Het
Or2w2	T	C	13: 21,758,341 (GRCm39)	D95G	possibly damaging	Het
Or51e1	T	C	7: 102,359,410 (GRCm39)	S315P	probably damaging	Het
Rai14	A	G	15: 10,595,948 (GRCm39)	S118P	possibly damaging	Het
Serpinb7	T	C	1: 107,379,399 (GRCm39)	S269P	probably benign	Het
Sesn3	C	T	9: 14,231,696 (GRCm39)	T209I	probably damaging	Het
Slit1	T	A	19: 41,596,817 (GRCm39)	N1094I	probably damaging	Het
Tep1	C	T	14: 51,061,955 (GRCm39)		probably benign	Het
Top1mt	A	G	15: 75,528,992 (GRCm39)	F584S	possibly damaging	Het
Trim44	A	T	2: 102,230,362 (GRCm39)	L223Q	probably benign	Het
Trim69	T	A	2: 121,998,397 (GRCm39)	L123Q	probably damaging	Het
Ubr2	A	T	17: 47,265,875 (GRCm39)	L1153I	possibly damaging	Het
Unc13a	G	A	8: 72,087,187 (GRCm39)	T1520I	possibly damaging	Het
Vmn2r105	A	C	17: 20,428,973 (GRCm39)	I701S	possibly damaging	Het
Wrn	T	C	8: 33,809,208 (GRCm39)	T263A	probably benign	Het
Ythdf2	T	C	4: 131,938,085 (GRCm39)	Y37C	probably damaging	Het
Zfp169	T	C	13: 48,644,239 (GRCm39)		probably benign	Het

Other mutations in Yeats2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01118:Yeats2	APN	16	20,005,054 (GRCm39)	missense	probably damaging	0.99
IGL01128:Yeats2	APN	16	19,980,718 (GRCm39)	splice site	probably benign
IGL01139:Yeats2	APN	16	20,033,143 (GRCm39)	missense	probably damaging	1.00
IGL01394:Yeats2	APN	16	19,980,782 (GRCm39)	missense	probably damaging	0.99
IGL01482:Yeats2	APN	16	20,041,671 (GRCm39)	missense	probably damaging	1.00
IGL01924:Yeats2	APN	16	20,024,917 (GRCm39)	missense	probably damaging	1.00
IGL02106:Yeats2	APN	16	20,011,970 (GRCm39)	missense	possibly damaging	0.79
IGL02370:Yeats2	APN	16	19,969,221 (GRCm39)	missense	probably damaging	0.99
IGL02447:Yeats2	APN	16	20,012,429 (GRCm39)	missense	probably benign	0.00
IGL02669:Yeats2	APN	16	20,005,033 (GRCm39)	missense	probably benign	0.13
IGL03155:Yeats2	APN	16	20,048,323 (GRCm39)	critical splice donor site	probably null
tyrion	UTSW	16	20,032,151 (GRCm39)	splice site	probably benign
P0045:Yeats2	UTSW	16	19,975,695 (GRCm39)	missense	possibly damaging	0.47
R0051:Yeats2	UTSW	16	20,012,474 (GRCm39)	nonsense	probably null
R0051:Yeats2	UTSW	16	20,012,474 (GRCm39)	nonsense	probably null
R0118:Yeats2	UTSW	16	19,975,692 (GRCm39)	nonsense	probably null
R0157:Yeats2	UTSW	16	20,040,427 (GRCm39)	makesense	probably null
R0184:Yeats2	UTSW	16	20,022,435 (GRCm39)	missense	possibly damaging	0.79
R0194:Yeats2	UTSW	16	19,971,719 (GRCm39)	start codon destroyed	probably null	1.00
R0612:Yeats2	UTSW	16	20,005,175 (GRCm39)	missense	probably benign	0.00
R0655:Yeats2	UTSW	16	20,012,574 (GRCm39)	nonsense	probably null
R0826:Yeats2	UTSW	16	20,011,966 (GRCm39)	nonsense	probably null
R1526:Yeats2	UTSW	16	20,024,836 (GRCm39)	missense	probably damaging	1.00
R1535:Yeats2	UTSW	16	20,008,115 (GRCm39)	missense	probably damaging	0.99
R1749:Yeats2	UTSW	16	20,005,018 (GRCm39)	nonsense	probably null
R1842:Yeats2	UTSW	16	19,989,988 (GRCm39)	missense	probably damaging	1.00
R1843:Yeats2	UTSW	16	20,048,314 (GRCm39)	missense	probably benign	0.01
R1926:Yeats2	UTSW	16	20,033,176 (GRCm39)	missense	probably benign
R2000:Yeats2	UTSW	16	20,005,141 (GRCm39)	missense	probably benign	0.20
R2017:Yeats2	UTSW	16	19,977,931 (GRCm39)	missense	probably benign	0.01
R2076:Yeats2	UTSW	16	20,005,032 (GRCm39)	missense	possibly damaging	0.47
R2153:Yeats2	UTSW	16	19,972,916 (GRCm39)	missense	probably damaging	1.00
R2167:Yeats2	UTSW	16	20,032,151 (GRCm39)	splice site	probably benign
R2981:Yeats2	UTSW	16	20,005,051 (GRCm39)	missense	probably damaging	0.99
R3160:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3161:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3162:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3774:Yeats2	UTSW	16	19,969,245 (GRCm39)	missense	probably damaging	1.00
R4250:Yeats2	UTSW	16	19,975,685 (GRCm39)	missense	possibly damaging	0.90
R4305:Yeats2	UTSW	16	20,027,172 (GRCm39)	missense	probably damaging	1.00
R4455:Yeats2	UTSW	16	19,980,743 (GRCm39)	missense	possibly damaging	0.88
R4458:Yeats2	UTSW	16	20,032,071 (GRCm39)	missense	probably damaging	0.99
R4811:Yeats2	UTSW	16	19,971,645 (GRCm39)	splice site	probably null
R4902:Yeats2	UTSW	16	20,026,418 (GRCm39)	missense	probably benign	0.00
R5043:Yeats2	UTSW	16	20,027,215 (GRCm39)	missense	probably damaging	1.00
R5047:Yeats2	UTSW	16	20,027,215 (GRCm39)	missense	probably damaging	1.00
R5319:Yeats2	UTSW	16	20,005,175 (GRCm39)	missense	probably benign	0.01
R5328:Yeats2	UTSW	16	19,989,955 (GRCm39)	missense	probably damaging	1.00
R5360:Yeats2	UTSW	16	19,972,912 (GRCm39)	missense	probably damaging	0.97
R5416:Yeats2	UTSW	16	20,030,319 (GRCm39)	missense	probably benign	0.01
R5672:Yeats2	UTSW	16	19,980,779 (GRCm39)	missense	probably damaging	1.00
R5684:Yeats2	UTSW	16	20,012,553 (GRCm39)	missense	possibly damaging	0.94
R5932:Yeats2	UTSW	16	20,011,913 (GRCm39)	missense	probably benign	0.06
R5946:Yeats2	UTSW	16	20,026,513 (GRCm39)	nonsense	probably null
R6168:Yeats2	UTSW	16	19,998,308 (GRCm39)	missense	probably benign	0.01
R6169:Yeats2	UTSW	16	20,038,417 (GRCm39)	missense	probably damaging	1.00
R6179:Yeats2	UTSW	16	20,033,225 (GRCm39)	missense	probably benign	0.16
R6371:Yeats2	UTSW	16	20,040,460 (GRCm39)	missense	possibly damaging	0.54
R6877:Yeats2	UTSW	16	19,998,344 (GRCm39)	missense	probably benign	0.00
R7149:Yeats2	UTSW	16	19,972,939 (GRCm39)	missense	probably damaging	1.00
R7405:Yeats2	UTSW	16	20,041,663 (GRCm39)	missense	probably damaging	1.00
R8353:Yeats2	UTSW	16	20,041,637 (GRCm39)	nonsense	probably null
R8367:Yeats2	UTSW	16	20,041,575 (GRCm39)	missense	probably damaging	1.00
R8453:Yeats2	UTSW	16	20,041,637 (GRCm39)	nonsense	probably null
R8506:Yeats2	UTSW	16	19,971,684 (GRCm39)	missense	probably damaging	0.98
R8535:Yeats2	UTSW	16	19,977,926 (GRCm39)	missense	probably damaging	1.00
R8828:Yeats2	UTSW	16	19,969,260 (GRCm39)	missense	probably benign	0.45
R8905:Yeats2	UTSW	16	20,009,144 (GRCm39)	missense	probably benign	0.02
R8924:Yeats2	UTSW	16	19,969,312 (GRCm39)	critical splice donor site	probably null
R9087:Yeats2	UTSW	16	20,030,500 (GRCm39)	critical splice donor site	probably null
R9276:Yeats2	UTSW	16	19,975,786 (GRCm39)	missense	probably benign	0.34
R9338:Yeats2	UTSW	16	20,041,533 (GRCm39)	missense	probably damaging	0.99
R9338:Yeats2	UTSW	16	20,032,078 (GRCm39)	missense	possibly damaging	0.69
R9378:Yeats2	UTSW	16	20,033,228 (GRCm39)	missense	probably benign
R9569:Yeats2	UTSW	16	19,972,902 (GRCm39)	missense	probably damaging	1.00
R9664:Yeats2	UTSW	16	20,047,491 (GRCm39)	nonsense	probably null

Posted On

2014-05-07