Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01927:Vmn2r1'

180326

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r1

Ensembl Gene

ENSMUSG00000027824

Gene Name

vomeronasal 2, receptor 1

Synonyms

V2r83, EG56544

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL01927

Quality Score

Status

Chromosome

Chromosomal Location

63988968-64016905 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 63989105 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 15 (F15L)

Ref Sequence

ENSEMBL: ENSMUSP00000029406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029406]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000029406
AA Change: F15L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: F15L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	86	504	6e-92	PFAM
Pfam:NCD3G	546	599	2.4e-17	PFAM
Pfam:7tm_3	632	866	4.1e-48	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	A	G	2: 35,266,026 (GRCm39)	Y215H	probably damaging	Het
Acsm2	T	C	7: 119,177,435 (GRCm39)	F317L	possibly damaging	Het
Akr1d1	A	G	6: 37,541,394 (GRCm39)	D297G	probably benign	Het
Atp10b	A	G	11: 43,150,231 (GRCm39)		probably benign	Het
Atp8b4	T	C	2: 126,164,896 (GRCm39)	Y1140C	probably damaging	Het
Cap2	T	A	13: 46,789,109 (GRCm39)	S105T	probably benign	Het
Cspg5	A	T	9: 110,091,152 (GRCm39)	I414F	probably damaging	Het
Dipk1b	A	G	2: 26,526,127 (GRCm39)	M354V	probably benign	Het
Ereg	T	A	5: 91,234,671 (GRCm39)	V28E	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Ift81	G	A	5: 122,731,192 (GRCm39)	T321M	probably benign	Het
Kcnip2	T	A	19: 45,784,044 (GRCm39)	Q95L	probably damaging	Het
Meis1	C	T	11: 18,831,811 (GRCm39)	R409H	probably benign	Het
Opa1	T	C	16: 29,405,813 (GRCm39)	I126T	probably benign	Het
Osbpl8	T	C	10: 111,106,477 (GRCm39)	Y295H	probably benign	Het
Ppip5k2	A	T	1: 97,640,848 (GRCm39)	V1005E	probably damaging	Het
Prdm10	A	G	9: 31,246,694 (GRCm39)		probably benign	Het
Rptor	T	A	11: 119,548,500 (GRCm39)	V58E	probably damaging	Het
Togaram1	C	T	12: 65,023,476 (GRCm39)	A687V	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r82	T	C	10: 79,213,906 (GRCm39)	L164P	probably damaging	Het
Zfp623	T	A	15: 75,819,354 (GRCm39)	N103K	possibly damaging	Het

Other mutations in Vmn2r1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Vmn2r1	APN	3	64,012,389 (GRCm39)	nonsense	probably null
IGL00335:Vmn2r1	APN	3	64,012,809 (GRCm39)	missense	probably damaging	0.96
IGL01509:Vmn2r1	APN	3	64,010,466 (GRCm39)	missense	probably benign	0.03
IGL01641:Vmn2r1	APN	3	64,011,924 (GRCm39)	missense	probably benign	0.19
IGL01656:Vmn2r1	APN	3	63,989,274 (GRCm39)	missense	probably damaging	0.96
IGL02093:Vmn2r1	APN	3	64,012,130 (GRCm39)	missense	probably benign
IGL02146:Vmn2r1	APN	3	64,012,104 (GRCm39)	missense	probably benign	0.39
IGL02186:Vmn2r1	APN	3	63,989,138 (GRCm39)	missense	probably benign	0.01
IGL02320:Vmn2r1	APN	3	63,989,180 (GRCm39)	missense	possibly damaging	0.61
IGL02423:Vmn2r1	APN	3	63,997,665 (GRCm39)	missense	probably benign	0.00
IGL02709:Vmn2r1	APN	3	64,012,355 (GRCm39)	missense	probably benign	0.24
R0034:Vmn2r1	UTSW	3	63,997,435 (GRCm39)	missense	probably damaging	1.00
R0064:Vmn2r1	UTSW	3	64,012,209 (GRCm39)	missense	possibly damaging	0.76
R0152:Vmn2r1	UTSW	3	63,989,240 (GRCm39)	missense	possibly damaging	0.92
R0305:Vmn2r1	UTSW	3	63,997,087 (GRCm39)	missense	probably damaging	1.00
R0314:Vmn2r1	UTSW	3	63,993,980 (GRCm39)	missense	probably damaging	1.00
R0317:Vmn2r1	UTSW	3	63,989,240 (GRCm39)	missense	possibly damaging	0.92
R0465:Vmn2r1	UTSW	3	63,989,180 (GRCm39)	missense	possibly damaging	0.61
R1144:Vmn2r1	UTSW	3	63,997,541 (GRCm39)	missense	probably damaging	1.00
R1163:Vmn2r1	UTSW	3	63,994,046 (GRCm39)	missense	probably benign	0.03
R1448:Vmn2r1	UTSW	3	64,008,734 (GRCm39)	missense	probably damaging	1.00
R1491:Vmn2r1	UTSW	3	63,997,034 (GRCm39)	missense	probably damaging	1.00
R1543:Vmn2r1	UTSW	3	63,996,994 (GRCm39)	missense	probably damaging	1.00
R1611:Vmn2r1	UTSW	3	64,011,958 (GRCm39)	nonsense	probably null
R1676:Vmn2r1	UTSW	3	63,997,603 (GRCm39)	nonsense	probably null
R1727:Vmn2r1	UTSW	3	63,989,163 (GRCm39)	missense	probably benign
R1851:Vmn2r1	UTSW	3	64,008,926 (GRCm39)	missense	probably benign	0.32
R3080:Vmn2r1	UTSW	3	63,997,205 (GRCm39)	missense	probably damaging	1.00
R3790:Vmn2r1	UTSW	3	63,994,185 (GRCm39)	critical splice donor site	probably null
R4111:Vmn2r1	UTSW	3	63,997,176 (GRCm39)	missense	probably benign	0.23
R4689:Vmn2r1	UTSW	3	64,012,074 (GRCm39)	missense	possibly damaging	0.94
R4747:Vmn2r1	UTSW	3	63,989,267 (GRCm39)	missense	probably benign	0.00
R4970:Vmn2r1	UTSW	3	63,997,544 (GRCm39)	missense	possibly damaging	0.81
R5033:Vmn2r1	UTSW	3	64,012,501 (GRCm39)	missense	probably damaging	1.00
R5086:Vmn2r1	UTSW	3	63,997,418 (GRCm39)	missense	probably benign	0.00
R5112:Vmn2r1	UTSW	3	63,997,544 (GRCm39)	missense	possibly damaging	0.81
R5385:Vmn2r1	UTSW	3	64,008,819 (GRCm39)	missense	possibly damaging	0.89
R5629:Vmn2r1	UTSW	3	64,012,538 (GRCm39)	missense	possibly damaging	0.87
R5762:Vmn2r1	UTSW	3	63,997,474 (GRCm39)	missense	probably benign	0.24
R5867:Vmn2r1	UTSW	3	64,011,990 (GRCm39)	missense	probably benign
R5893:Vmn2r1	UTSW	3	63,993,974 (GRCm39)	missense	probably damaging	1.00
R6037:Vmn2r1	UTSW	3	63,989,150 (GRCm39)	missense	probably benign	0.00
R6037:Vmn2r1	UTSW	3	63,989,150 (GRCm39)	missense	probably benign	0.00
R6290:Vmn2r1	UTSW	3	64,012,873 (GRCm39)	missense	probably benign	0.02
R6443:Vmn2r1	UTSW	3	64,012,374 (GRCm39)	missense	possibly damaging	0.78
R6464:Vmn2r1	UTSW	3	64,008,766 (GRCm39)	missense	probably benign
R6826:Vmn2r1	UTSW	3	64,012,567 (GRCm39)	nonsense	probably null
R6874:Vmn2r1	UTSW	3	64,012,376 (GRCm39)	missense	probably damaging	1.00
R6882:Vmn2r1	UTSW	3	63,997,529 (GRCm39)	missense	possibly damaging	0.64
R6983:Vmn2r1	UTSW	3	63,989,118 (GRCm39)	missense	probably benign
R7010:Vmn2r1	UTSW	3	64,012,146 (GRCm39)	missense	probably benign	0.19
R7144:Vmn2r1	UTSW	3	63,997,362 (GRCm39)	missense	probably damaging	1.00
R7341:Vmn2r1	UTSW	3	64,012,877 (GRCm39)	makesense	probably null
R7510:Vmn2r1	UTSW	3	63,993,922 (GRCm39)	missense	probably damaging	1.00
R7557:Vmn2r1	UTSW	3	63,997,475 (GRCm39)	missense	probably damaging	0.99
R7895:Vmn2r1	UTSW	3	63,997,130 (GRCm39)	missense	possibly damaging	0.90
R8108:Vmn2r1	UTSW	3	64,010,471 (GRCm39)	missense	probably damaging	0.98
R8209:Vmn2r1	UTSW	3	63,997,199 (GRCm39)	missense	possibly damaging	0.64
R8365:Vmn2r1	UTSW	3	63,994,034 (GRCm39)	missense	possibly damaging	0.80
R8514:Vmn2r1	UTSW	3	63,993,942 (GRCm39)	missense	probably benign	0.11
R8554:Vmn2r1	UTSW	3	63,997,334 (GRCm39)	missense	probably damaging	0.98
R8980:Vmn2r1	UTSW	3	64,010,501 (GRCm39)	missense
R9140:Vmn2r1	UTSW	3	63,997,465 (GRCm39)	missense	probably benign	0.05
R9239:Vmn2r1	UTSW	3	64,011,959 (GRCm39)	missense	probably damaging	0.99
R9441:Vmn2r1	UTSW	3	64,012,674 (GRCm39)	missense	probably damaging	1.00
R9549:Vmn2r1	UTSW	3	63,997,493 (GRCm39)	missense	probably benign	0.17
R9771:Vmn2r1	UTSW	3	63,997,559 (GRCm39)	missense	possibly damaging	0.79
X0065:Vmn2r1	UTSW	3	63,997,678 (GRCm39)	nonsense	probably null

Posted On

2014-05-07