Incidental Mutation 'IGL01931:Oas1c'
ID180424
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1c
Ensembl Gene ENSMUSG00000001166
Gene Name2'-5' oligoadenylate synthetase 1C
SynonymsOasl5
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01931
Quality Score
Status
Chromosome5
Chromosomal Location120800194-120812514 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 120805495 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Serine at position 193 (I193S)
Ref Sequence ENSEMBL: ENSMUSP00000112584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117193] [ENSMUST00000125547]
Predicted Effect probably benign
Transcript: ENSMUST00000117193
AA Change: I193S

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166
AA Change: I193S

DomainStartEndE-ValueType
Pfam:OAS1_C 168 354 1.4e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130045
SMART Domains Protein: ENSMUSP00000122510
Gene: ENSMUSG00000001166

DomainStartEndE-ValueType
Pfam:OAS1_C 89 146 3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201006
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930533L02Rik A G 7: 125,318,697 E87G unknown Het
Ano2 A G 6: 125,982,745 Y656C probably damaging Het
Cckbr T C 7: 105,426,103 S27P probably benign Het
Celsr1 T A 15: 85,907,660 N2580I probably damaging Het
Cfap221 A G 1: 119,932,895 L667P probably damaging Het
Col16a1 T C 4: 130,072,841 C555R possibly damaging Het
Dync2h1 A G 9: 7,114,973 V162A probably damaging Het
Dync2h1 G A 9: 7,011,207 S3669L probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm4922 A G 10: 18,784,294 S227P probably benign Het
Grin2c A G 11: 115,253,910 F597L probably damaging Het
Hook3 G A 8: 26,088,055 probably benign Het
Ltv1 A G 10: 13,185,501 I106T probably damaging Het
Mdc1 T C 17: 35,848,231 V501A probably benign Het
Myo15 T A 11: 60,496,138 C667S probably damaging Het
Myom3 T C 4: 135,789,639 V840A probably benign Het
Naip1 G T 13: 100,409,032 C1329* probably null Het
Osbp2 C T 11: 3,705,388 probably null Het
Phf1 T C 17: 26,935,535 probably benign Het
Pisd C A 5: 32,739,132 probably null Het
Ppox T C 1: 171,277,883 Q302R probably null Het
Sec24b G A 3: 130,009,799 P305S probably benign Het
Spink5 A T 18: 44,015,638 I923F probably benign Het
Thsd7a A T 6: 12,504,099 V352E probably damaging Het
Tpi1 A G 6: 124,812,640 V152A possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Wdfy4 C T 14: 33,155,753 G85S probably damaging Het
Wnk4 A G 11: 101,268,484 T139A possibly damaging Het
Zfp345 T C 2: 150,473,350 H89R probably benign Het
Other mutations in Oas1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Oas1c APN 5 120808679 missense probably benign 0.00
IGL01472:Oas1c APN 5 120802921 missense probably damaging 1.00
IGL02429:Oas1c APN 5 120802068 missense probably benign 0.30
IGL02498:Oas1c APN 5 120805526 missense possibly damaging 0.83
IGL02696:Oas1c APN 5 120805463 missense probably benign 0.44
IGL02957:Oas1c APN 5 120805413 nonsense probably null
sandshrew UTSW 5 120808139 missense probably damaging 0.99
R0562:Oas1c UTSW 5 120805604 splice site probably benign
R1819:Oas1c UTSW 5 120808735 missense possibly damaging 0.89
R1853:Oas1c UTSW 5 120807995 missense probably damaging 1.00
R1937:Oas1c UTSW 5 120802984 missense probably benign 0.00
R2248:Oas1c UTSW 5 120802861 missense possibly damaging 0.48
R2258:Oas1c UTSW 5 120803017 missense probably null 1.00
R2570:Oas1c UTSW 5 120805438 missense probably benign 0.05
R3965:Oas1c UTSW 5 120808718 missense probably damaging 1.00
R4164:Oas1c UTSW 5 120808139 missense probably damaging 0.99
R5146:Oas1c UTSW 5 120802094 missense probably benign 0.08
R5875:Oas1c UTSW 5 120805562 missense probably damaging 1.00
R5938:Oas1c UTSW 5 120805533 missense probably benign 0.05
Posted On2014-05-07