Incidental Mutation 'IGL01934:Il24'
ID 180583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il24
Ensembl Gene ENSMUSG00000026420
Gene Name interleukin 24
Synonyms FISP, Mda-7
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01934
Quality Score
Status
Chromosome 1
Chromosomal Location 130809801-130815153 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130811614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 115 (L115Q)
Ref Sequence ENSEMBL: ENSMUSP00000140149 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038829] [ENSMUST00000121040] [ENSMUST00000187650] [ENSMUST00000188148] [ENSMUST00000191279]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000038829
SMART Domains Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:V-set 21 122 1.3e-10 PFAM
low complexity region 212 223 N/A INTRINSIC
transmembrane domain 264 283 N/A INTRINSIC
low complexity region 285 311 N/A INTRINSIC
low complexity region 344 363 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000121040
AA Change: L154Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113064
Gene: ENSMUSG00000026420
AA Change: L154Q

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
IL10 76 219 1.14e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126821
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145446
Predicted Effect probably damaging
Transcript: ENSMUST00000187650
AA Change: L115Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140149
Gene: ENSMUSG00000026420
AA Change: L115Q

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IL10 37 180 5.4e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188148
SMART Domains Protein: ENSMUSP00000139907
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 37 50 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000191279
SMART Domains Protein: ENSMUSP00000140821
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Blast:IL10 76 118 2e-21 BLAST
SCOP:d2ilk__ 80 119 2e-9 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display normal induction of epidermal hyperplasia in response to intradermal IL-23 treatment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik T C 14: 54,823,112 (GRCm39) K362E probably damaging Het
4932438H23Rik T A 16: 90,852,753 (GRCm39) T128S probably damaging Het
Aars1 T A 8: 111,774,650 (GRCm39) I593N probably damaging Het
Abca6 A T 11: 110,079,481 (GRCm39) N1224K probably benign Het
Abcc5 A T 16: 20,241,191 (GRCm39) probably benign Het
Adam7 A G 14: 68,770,048 (GRCm39) L35P probably damaging Het
Ahnak T A 19: 8,980,021 (GRCm39) L435Q probably damaging Het
Ankef1 A G 2: 136,394,451 (GRCm39) E620G possibly damaging Het
Aoc1l3 A T 6: 48,965,695 (GRCm39) I568F probably damaging Het
Ap3d1 A T 10: 80,545,092 (GRCm39) L1082* probably null Het
Atp6v0a4 T A 6: 38,028,481 (GRCm39) I712F possibly damaging Het
Bco1 T A 8: 117,822,784 (GRCm39) F5L possibly damaging Het
Cacna2d4 A T 6: 119,285,729 (GRCm39) S794C probably damaging Het
Camk2d T C 3: 126,628,304 (GRCm39) probably null Het
Capn15 T C 17: 26,181,998 (GRCm39) T604A probably damaging Het
Cd180 A T 13: 102,839,366 (GRCm39) D83V probably damaging Het
Ces1a C A 8: 93,759,278 (GRCm39) R286L probably damaging Het
Col6a6 A G 9: 105,575,858 (GRCm39) probably null Het
Crnkl1 A G 2: 145,773,202 (GRCm39) V148A probably benign Het
Epas1 A T 17: 87,131,157 (GRCm39) K312N probably damaging Het
Fbxw2 T C 2: 34,712,618 (GRCm39) S148G probably damaging Het
Fig4 T C 10: 41,104,108 (GRCm39) T791A probably benign Het
Galnt9 A T 5: 110,750,502 (GRCm39) I340F possibly damaging Het
Gfap G A 11: 102,785,286 (GRCm39) A230V probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm454 T C 5: 138,205,424 (GRCm39) noncoding transcript Het
Ipp C A 4: 116,367,852 (GRCm39) N28K probably damaging Het
Kalrn A T 16: 34,018,882 (GRCm39) probably null Het
Klf10 C T 15: 38,297,528 (GRCm39) V171M probably benign Het
Man1b1 T C 2: 25,235,523 (GRCm39) S350P probably benign Het
Mfsd4a T C 1: 131,974,049 (GRCm39) Y343C probably damaging Het
Mrpl58 C A 11: 115,301,555 (GRCm39) probably benign Het
Myo7b A G 18: 32,134,394 (GRCm39) probably null Het
Nbas T C 12: 13,339,880 (GRCm39) probably benign Het
Nisch A G 14: 30,898,696 (GRCm39) probably benign Het
Or1o2 A T 17: 37,542,439 (GRCm39) V274D probably damaging Het
Or52z14 T C 7: 103,253,182 (GRCm39) F107S probably damaging Het
Or5p69 A G 7: 107,967,368 (GRCm39) I224V probably damaging Het
Parva T A 7: 112,187,760 (GRCm39) C352* probably null Het
Ptf1a T A 2: 19,451,431 (GRCm39) C254S possibly damaging Het
R3hdm1 G T 1: 128,164,272 (GRCm39) R1062L probably benign Het
Rnf44 A G 13: 54,829,763 (GRCm39) V407A probably damaging Het
Shank3 T C 15: 89,434,049 (GRCm39) L1598P probably damaging Het
Slit2 T C 5: 48,395,747 (GRCm39) S717P possibly damaging Het
Tdpoz4 A G 3: 93,704,779 (GRCm39) K359E probably damaging Het
Tmtc4 A T 14: 123,165,047 (GRCm39) L604* probably null Het
Tnfrsf21 A T 17: 43,376,078 (GRCm39) N488I probably benign Het
Tnfsf8 A G 4: 63,752,747 (GRCm39) probably benign Het
Tnpo3 A T 6: 29,575,019 (GRCm39) L382M probably benign Het
Tut1 T C 19: 8,931,355 (GRCm39) C18R probably damaging Het
Ugt8a A G 3: 125,708,424 (GRCm39) S229P probably benign Het
Usp22 T C 11: 61,046,114 (GRCm39) E476G probably damaging Het
Vill G T 9: 118,895,877 (GRCm39) A146S probably damaging Het
Vmn1r178 T C 7: 23,593,362 (GRCm39) Y137H probably damaging Het
Wdfy1 A T 1: 79,717,833 (GRCm39) W51R probably damaging Het
Zc3hav1 A T 6: 38,296,768 (GRCm39) probably null Het
Zfp236 A T 18: 82,651,245 (GRCm39) V889E probably damaging Het
Zscan20 T C 4: 128,486,277 (GRCm39) D141G possibly damaging Het
Other mutations in Il24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02540:Il24 APN 1 130,815,040 (GRCm39) unclassified probably benign
IGL02959:Il24 APN 1 130,813,470 (GRCm39) nonsense probably null
IGL03191:Il24 APN 1 130,812,584 (GRCm39) missense probably benign 0.06
R0360:Il24 UTSW 1 130,811,674 (GRCm39) missense probably damaging 1.00
R1738:Il24 UTSW 1 130,815,099 (GRCm39) splice site probably null
R1755:Il24 UTSW 1 130,811,680 (GRCm39) missense possibly damaging 0.58
R1984:Il24 UTSW 1 130,810,268 (GRCm39) missense probably benign 0.01
R1985:Il24 UTSW 1 130,810,268 (GRCm39) missense probably benign 0.01
R1986:Il24 UTSW 1 130,810,268 (GRCm39) missense probably benign 0.01
R2090:Il24 UTSW 1 130,812,574 (GRCm39) missense possibly damaging 0.90
R4970:Il24 UTSW 1 130,811,179 (GRCm39) splice site probably null
R5112:Il24 UTSW 1 130,811,179 (GRCm39) splice site probably null
R5590:Il24 UTSW 1 130,810,253 (GRCm39) missense possibly damaging 0.72
R6128:Il24 UTSW 1 130,813,435 (GRCm39) missense probably damaging 0.97
R7061:Il24 UTSW 1 130,811,108 (GRCm39) missense possibly damaging 0.81
R9114:Il24 UTSW 1 130,813,483 (GRCm39) missense possibly damaging 0.86
R9465:Il24 UTSW 1 130,813,462 (GRCm39) missense probably benign 0.18
X0021:Il24 UTSW 1 130,813,322 (GRCm39) missense probably benign 0.06
Posted On 2014-05-07