Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01939:Or8g33'

180792

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8g33

Ensembl Gene

ENSMUSG00000058856

Gene Name

olfactory receptor family 8 subfamily G member 33

Synonyms

GA_x6K02T2PVTD-33124064-33123120, MOR171-21, Olfr952

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL01939

Quality Score

Status

Chromosome

Chromosomal Location

39337389-39338444 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 39337634 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 244 (H244Q)

Ref Sequence

ENSEMBL: ENSMUSP00000073558 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073895]

AlphaFold

Q8VFD7

Predicted Effect

probably damaging
Transcript: ENSMUST00000073895
AA Change: H244Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073558
Gene: ENSMUSG00000058856
AA Change: H244Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8.5e-42	PFAM
Pfam:7tm_1	41	294	3.2e-18	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb2	G	T	4: 129,885,925 (GRCm39)	D22Y	probably damaging	Het
Ak7	T	C	12: 105,701,183 (GRCm39)	V242A	probably benign	Het
Cacna1b	T	C	2: 24,551,769 (GRCm39)	N1127S	probably damaging	Het
Cacnb2	A	T	2: 14,976,380 (GRCm39)	H267L	probably benign	Het
Ces1b	C	T	8: 93,806,059 (GRCm39)	G61R	probably damaging	Het
Cgnl1	T	A	9: 71,632,286 (GRCm39)	D355V	probably damaging	Het
Col24a1	T	C	3: 145,021,005 (GRCm39)	S459P	probably damaging	Het
Crygd	T	C	1: 65,101,185 (GRCm39)	T137A	probably benign	Het
Dctn4	T	A	18: 60,677,202 (GRCm39)	M174K	probably benign	Het
Evi5	A	G	5: 107,964,790 (GRCm39)		probably benign	Het
Fat2	T	G	11: 55,174,806 (GRCm39)	D1969A	probably benign	Het
Fcrl5	A	T	3: 87,353,606 (GRCm39)	E317V	probably damaging	Het
Foxf2	G	T	13: 31,810,697 (GRCm39)	S212I	probably damaging	Het
Gm21759	T	A	5: 8,230,685 (GRCm39)		probably benign	Het
Gm5414	A	G	15: 101,534,105 (GRCm39)		probably benign	Het
Gm7275	T	C	16: 47,893,946 (GRCm39)		noncoding transcript	Het
Hspa9	T	C	18: 35,071,761 (GRCm39)	E613G	possibly damaging	Het
Il1rl1	A	G	1: 40,501,168 (GRCm39)	I515V	possibly damaging	Het
Ins1	G	T	19: 52,253,173 (GRCm39)	A38S	probably damaging	Het
Klhl31	A	G	9: 77,562,488 (GRCm39)	N418D	probably benign	Het
Magi3	T	C	3: 103,961,778 (GRCm39)	K417E	probably damaging	Het
Msh4	A	G	3: 153,563,226 (GRCm39)	Y823H	probably damaging	Het
Myo6	T	A	9: 80,168,100 (GRCm39)	D421E	probably damaging	Het
Myom3	T	C	4: 135,492,900 (GRCm39)	S150P	possibly damaging	Het
Nectin1	C	T	9: 43,703,871 (GRCm39)		probably benign	Het
Nkx1-2	A	T	7: 132,201,203 (GRCm39)	I18N	probably damaging	Het
Or4s2b	A	G	2: 88,509,077 (GRCm39)	T286A	probably damaging	Het
Or5b113	A	T	19: 13,342,807 (GRCm39)	I272F	probably benign	Het
Or9g4	T	C	2: 85,505,285 (GRCm39)	D70G	probably damaging	Het
Pde8b	T	C	13: 95,232,232 (GRCm39)	R237G	probably damaging	Het
Pp2d1	G	A	17: 53,822,167 (GRCm39)	L300F	probably damaging	Het
Ptpn21	A	T	12: 98,655,420 (GRCm39)	Y516N	probably damaging	Het
Ptprm	T	A	17: 67,370,158 (GRCm39)		probably benign	Het
Rabggtb	A	G	3: 153,617,650 (GRCm39)	V16A	probably damaging	Het
Rangap1	A	T	15: 81,604,864 (GRCm39)	C82S	probably damaging	Het
Rasal2	T	C	1: 157,003,480 (GRCm39)	E393G	probably damaging	Het
Rasgrf1	A	T	9: 89,856,889 (GRCm39)	E449V	probably damaging	Het
Rrp12	A	T	19: 41,859,334 (GRCm39)	H1143Q	probably damaging	Het
Scap	T	C	9: 110,208,549 (GRCm39)	I530T	probably benign	Het
Sel1l	T	A	12: 91,783,021 (GRCm39)	Q482L	probably damaging	Het
Serpinb9b	T	C	13: 33,223,648 (GRCm39)	M280T	probably damaging	Het
Slc39a10	T	A	1: 46,871,895 (GRCm39)	H348L	probably benign	Het
Slc7a2	T	C	8: 41,367,120 (GRCm39)	L542P	possibly damaging	Het
Tas1r2	A	T	4: 139,396,488 (GRCm39)	Q609L	probably damaging	Het
Tbc1d14	A	T	5: 36,665,781 (GRCm39)		probably benign	Het
Tfb2m	A	G	1: 179,365,262 (GRCm39)		probably null	Het
Tpo	T	C	12: 30,134,646 (GRCm39)	T771A	possibly damaging	Het
Tpr	G	A	1: 150,289,496 (GRCm39)	R609H	possibly damaging	Het
Usp34	T	A	11: 23,295,141 (GRCm39)		probably benign	Het
Vmn1r193	G	T	13: 22,403,893 (GRCm39)	S33*	probably null	Het
Vmn2r104	A	C	17: 20,250,187 (GRCm39)	S695A	probably damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r24	A	G	6: 123,764,404 (GRCm39)	D427G	probably benign	Het
Zfp362	A	G	4: 128,680,846 (GRCm39)	S160P	probably benign	Het

Other mutations in Or8g33

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00976:Or8g33	APN	9	39,337,953 (GRCm39)	missense	probably benign	0.02
IGL01368:Or8g33	APN	9	39,337,476 (GRCm39)	missense	probably damaging	1.00
IGL01866:Or8g33	APN	9	39,338,025 (GRCm39)	missense	probably damaging	0.99
IGL03048:Or8g33	UTSW	9	39,338,065 (GRCm39)	missense	probably benign	0.00
R0069:Or8g33	UTSW	9	39,338,188 (GRCm39)	missense	probably damaging	0.98
R1460:Or8g33	UTSW	9	39,337,503 (GRCm39)	missense	probably benign	0.43
R1478:Or8g33	UTSW	9	39,337,888 (GRCm39)	missense	possibly damaging	0.91
R1737:Or8g33	UTSW	9	39,338,254 (GRCm39)	missense	probably damaging	0.99
R2112:Or8g33	UTSW	9	39,337,966 (GRCm39)	missense	probably benign	0.26
R2169:Or8g33	UTSW	9	39,337,654 (GRCm39)	missense	possibly damaging	0.95
R2225:Or8g33	UTSW	9	39,337,915 (GRCm39)	missense	probably benign	0.00
R3731:Or8g33	UTSW	9	39,338,365 (GRCm39)	start codon destroyed	probably benign	0.23
R3777:Or8g33	UTSW	9	39,337,901 (GRCm39)	missense	possibly damaging	0.75
R3802:Or8g33	UTSW	9	39,337,582 (GRCm39)	missense	probably damaging	1.00
R4600:Or8g33	UTSW	9	39,337,731 (GRCm39)	missense	probably benign	0.27
R4887:Or8g33	UTSW	9	39,337,531 (GRCm39)	missense	possibly damaging	0.80
R5215:Or8g33	UTSW	9	39,337,919 (GRCm39)	nonsense	probably null
R5813:Or8g33	UTSW	9	39,338,032 (GRCm39)	missense	probably damaging	1.00
R6140:Or8g33	UTSW	9	39,337,543 (GRCm39)	missense	possibly damaging	0.91
R6180:Or8g33	UTSW	9	39,338,008 (GRCm39)	missense	probably damaging	1.00
R6383:Or8g33	UTSW	9	39,337,530 (GRCm39)	missense	probably damaging	1.00
R6416:Or8g33	UTSW	9	39,338,187 (GRCm39)	missense	probably damaging	0.98
R6808:Or8g33	UTSW	9	39,337,836 (GRCm39)	missense	probably damaging	0.99
R7099:Or8g33	UTSW	9	39,337,599 (GRCm39)	missense	probably benign	0.01
R7826:Or8g33	UTSW	9	39,337,423 (GRCm39)	makesense	probably null
R8309:Or8g33	UTSW	9	39,337,966 (GRCm39)	missense	probably benign	0.40
R8870:Or8g33	UTSW	9	39,337,548 (GRCm39)	missense	probably damaging	0.97
R8879:Or8g33	UTSW	9	39,337,515 (GRCm39)	missense	possibly damaging	0.86
R9084:Or8g33	UTSW	9	39,337,521 (GRCm39)	missense	probably damaging	1.00
R9209:Or8g33	UTSW	9	39,337,635 (GRCm39)	missense	probably damaging	0.99
R9435:Or8g33	UTSW	9	39,337,506 (GRCm39)	missense	probably benign
R9583:Or8g33	UTSW	9	39,337,851 (GRCm39)	missense	possibly damaging	0.91

Posted On

2014-05-07