Incidental Mutation 'IGL01942:Slc25a28'
ID180882
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc25a28
Ensembl Gene ENSMUSG00000040414
Gene Namesolute carrier family 25, member 28
Synonyms2210403D18Rik, Mrs3/4, Mfrn2
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.414) question?
Stock #IGL01942
Quality Score
Status
Chromosome19
Chromosomal Location43663822-43674881 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 43664508 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 238 (F238S)
Ref Sequence ENSEMBL: ENSMUSP00000036913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046038]
Predicted Effect probably damaging
Transcript: ENSMUST00000046038
AA Change: F238S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000036913
Gene: ENSMUSG00000040414
AA Change: F238S

DomainStartEndE-ValueType
low complexity region 4 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
Pfam:Mito_carr 69 162 6.2e-22 PFAM
Pfam:Mito_carr 167 257 1e-19 PFAM
Pfam:Mito_carr 257 357 2.5e-22 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 G A 7: 45,986,573 R1017W possibly damaging Het
Arhgef26 A G 3: 62,340,094 R200G probably benign Het
Arid4b A T 13: 14,136,164 probably benign Het
Atp1a2 A C 1: 172,286,309 S369A probably benign Het
Bag3 T A 7: 128,546,300 D546E probably benign Het
Bcl6b T A 11: 70,226,743 Y379F probably damaging Het
Cbln2 T C 18: 86,716,325 V136A probably benign Het
Ccnf A T 17: 24,242,320 D120E probably benign Het
Cd14 T A 18: 36,725,640 H254L possibly damaging Het
Chd3 A G 11: 69,350,105 probably null Het
Csf2rb G A 15: 78,340,492 R150H probably benign Het
Dhx35 T C 2: 158,831,864 L405P probably damaging Het
Dpf1 G A 7: 29,316,502 C383Y probably damaging Het
Dse T A 10: 34,155,993 Q345L probably benign Het
Gnaz A G 10: 75,014,874 M244V probably damaging Het
Gpr65 A T 12: 98,275,715 Y209F possibly damaging Het
Inpp5f T C 7: 128,667,769 I281T probably damaging Het
Kntc1 T C 5: 123,778,267 F721S probably damaging Het
Mapk8ip2 G A 15: 89,457,017 probably null Het
Med24 G A 11: 98,709,682 R646W probably damaging Het
Nup98 A T 7: 102,194,711 F102Y probably damaging Het
Olfr1260 G T 2: 89,977,978 V67L probably benign Het
Olfr150 A T 9: 39,737,666 M284L possibly damaging Het
Olfr354 A G 2: 36,907,857 M304V probably benign Het
Pgap3 T C 11: 98,397,954 Y125C probably damaging Het
Rasl12 T C 9: 65,408,362 V96A probably damaging Het
Rbm20 G A 19: 53,813,443 M127I probably damaging Het
Rnf114 T A 2: 167,512,626 probably null Het
Serpinb1b C T 13: 33,085,311 T9I possibly damaging Het
Setd1b T A 5: 123,163,426 F16I possibly damaging Het
Slc2a2 T C 3: 28,705,803 V30A probably damaging Het
Slc35f4 T C 14: 49,525,505 probably benign Het
Socs4 T A 14: 47,290,650 C347* probably null Het
Spock1 C T 13: 57,430,328 E367K probably damaging Het
Ubap2 C T 4: 41,251,608 R8H probably benign Het
Vmn1r44 T A 6: 89,893,824 M41K probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp575 T C 7: 24,585,815 T134A possibly damaging Het
Other mutations in Slc25a28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02572:Slc25a28 APN 19 43664446 missense probably damaging 1.00
IGL02678:Slc25a28 APN 19 43667147 splice site probably benign
R0732:Slc25a28 UTSW 19 43666953 missense probably benign 0.00
R1307:Slc25a28 UTSW 19 43667031 missense probably benign 0.28
R3950:Slc25a28 UTSW 19 43664269 missense probably benign 0.01
R6057:Slc25a28 UTSW 19 43666925 missense possibly damaging 0.69
R6292:Slc25a28 UTSW 19 43664592 missense probably benign 0.04
Posted On2014-05-07