Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01942:Zfp575'

180884

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp575

Ensembl Gene

ENSMUSG00000066721

Gene Name

zinc finger protein 575

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

IGL01942

Quality Score

Status

Chromosome

Chromosomal Location

24283942-24287049 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 24285240 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 134 (T134A)

Ref Sequence

ENSEMBL: ENSMUSP00000092294 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077191] [ENSMUST00000094705]

AlphaFold

Q3TXZ1

Predicted Effect

probably benign
Transcript: ENSMUST00000077191

SMART Domains

Protein: ENSMUSP00000076433
Gene: ENSMUSG00000064254

Domain	Start	End	E-Value	Type
Lactamase_B	34	195	1.05e-22	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094705
AA Change: T134A

PolyPhen 2 Score 0.579 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000092294
Gene: ENSMUSG00000066721
AA Change: T134A

Domain	Start	End	E-Value	Type
ZnF_C2H2	57	79	3.58e-2	SMART
ZnF_C2H2	85	107	4.11e-2	SMART
ZnF_C2H2	113	135	1.14e0	SMART
ZnF_C2H2	141	163	2.71e-2	SMART
ZnF_C2H2	171	193	1.08e-1	SMART
ZnF_C2H2	207	229	8.81e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	G	A	7: 45,635,997 (GRCm39)	R1017W	possibly damaging	Het
Arhgef26	A	G	3: 62,247,515 (GRCm39)	R200G	probably benign	Het
Arid4b	A	T	13: 14,310,749 (GRCm39)		probably benign	Het
Atp1a2	A	C	1: 172,113,876 (GRCm39)	S369A	probably benign	Het
Bag3	T	A	7: 128,148,024 (GRCm39)	D546E	probably benign	Het
Bcl6b	T	A	11: 70,117,569 (GRCm39)	Y379F	probably damaging	Het
Cbln2	T	C	18: 86,734,450 (GRCm39)	V136A	probably benign	Het
Ccnf	A	T	17: 24,461,294 (GRCm39)	D120E	probably benign	Het
Cd14	T	A	18: 36,858,693 (GRCm39)	H254L	possibly damaging	Het
Chd3	A	G	11: 69,240,931 (GRCm39)		probably null	Het
Csf2rb	G	A	15: 78,224,692 (GRCm39)	R150H	probably benign	Het
Dhx35	T	C	2: 158,673,784 (GRCm39)	L405P	probably damaging	Het
Dpf1	G	A	7: 29,015,927 (GRCm39)	C383Y	probably damaging	Het
Dse	T	A	10: 34,031,989 (GRCm39)	Q345L	probably benign	Het
Gnaz	A	G	10: 74,850,706 (GRCm39)	M244V	probably damaging	Het
Gpr65	A	T	12: 98,241,974 (GRCm39)	Y209F	possibly damaging	Het
Inpp5f	T	C	7: 128,269,493 (GRCm39)	I281T	probably damaging	Het
Kntc1	T	C	5: 123,916,330 (GRCm39)	F721S	probably damaging	Het
Mapk8ip2	G	A	15: 89,341,220 (GRCm39)		probably null	Het
Med24	G	A	11: 98,600,508 (GRCm39)	R646W	probably damaging	Het
Nup98	A	T	7: 101,843,918 (GRCm39)	F102Y	probably damaging	Het
Or1n2	A	G	2: 36,797,869 (GRCm39)	M304V	probably benign	Het
Or4c35	G	T	2: 89,808,322 (GRCm39)	V67L	probably benign	Het
Or8g50	A	T	9: 39,648,962 (GRCm39)	M284L	possibly damaging	Het
Pgap3	T	C	11: 98,288,780 (GRCm39)	Y125C	probably damaging	Het
Rasl12	T	C	9: 65,315,644 (GRCm39)	V96A	probably damaging	Het
Rbm20	G	A	19: 53,801,874 (GRCm39)	M127I	probably damaging	Het
Rnf114	T	A	2: 167,354,546 (GRCm39)		probably null	Het
Serpinb1b	C	T	13: 33,269,294 (GRCm39)	T9I	possibly damaging	Het
Setd1b	T	A	5: 123,301,489 (GRCm39)	F16I	possibly damaging	Het
Slc25a28	A	G	19: 43,652,947 (GRCm39)	F238S	probably damaging	Het
Slc2a2	T	C	3: 28,759,952 (GRCm39)	V30A	probably damaging	Het
Slc35f4	T	C	14: 49,762,962 (GRCm39)		probably benign	Het
Socs4	T	A	14: 47,528,107 (GRCm39)	C347*	probably null	Het
Spock1	C	T	13: 57,578,141 (GRCm39)	E367K	probably damaging	Het
Ubap2	C	T	4: 41,251,608 (GRCm39)	R8H	probably benign	Het
Vmn1r44	T	A	6: 89,870,806 (GRCm39)	M41K	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het

Other mutations in Zfp575

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01293:Zfp575	APN	7	24,285,182 (GRCm39)	missense	probably damaging	1.00
IGL03136:Zfp575	APN	7	24,285,381 (GRCm39)	missense	probably damaging	1.00
R0051:Zfp575	UTSW	7	24,285,512 (GRCm39)	missense	probably benign
R0834:Zfp575	UTSW	7	24,285,245 (GRCm39)	missense	probably damaging	1.00
R2251:Zfp575	UTSW	7	24,285,015 (GRCm39)	missense	probably damaging	1.00
R4036:Zfp575	UTSW	7	24,285,440 (GRCm39)	missense	possibly damaging	0.94
R5416:Zfp575	UTSW	7	24,286,147 (GRCm39)	missense	probably benign
R5625:Zfp575	UTSW	7	24,285,077 (GRCm39)	missense	possibly damaging	0.61
R5782:Zfp575	UTSW	7	24,285,027 (GRCm39)	missense	possibly damaging	0.64
R7599:Zfp575	UTSW	7	24,286,093 (GRCm39)	missense	probably benign	0.24
R9666:Zfp575	UTSW	7	24,285,323 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07