Incidental Mutation 'IGL01942:Olfr354'
ID180889
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr354
Ensembl Gene ENSMUSG00000055088
Gene Nameolfactory receptor 354
SynonymsGA_x6K02T2NLDC-33601476-33602429, MOR127-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.133) question?
Stock #IGL01942
Quality Score
Status
Chromosome2
Chromosomal Location36905680-36916038 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 36907857 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 304 (M304V)
Ref Sequence ENSEMBL: ENSMUSP00000149298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]
Predicted Effect probably benign
Transcript: ENSMUST00000068475
AA Change: M304V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088
AA Change: M304V

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2.1e-62 PFAM
Pfam:7tm_1 44 293 2.9e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121665
Predicted Effect probably benign
Transcript: ENSMUST00000217479
AA Change: M304V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218102
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 G A 7: 45,986,573 R1017W possibly damaging Het
Arhgef26 A G 3: 62,340,094 R200G probably benign Het
Arid4b A T 13: 14,136,164 probably benign Het
Atp1a2 A C 1: 172,286,309 S369A probably benign Het
Bag3 T A 7: 128,546,300 D546E probably benign Het
Bcl6b T A 11: 70,226,743 Y379F probably damaging Het
Cbln2 T C 18: 86,716,325 V136A probably benign Het
Ccnf A T 17: 24,242,320 D120E probably benign Het
Cd14 T A 18: 36,725,640 H254L possibly damaging Het
Chd3 A G 11: 69,350,105 probably null Het
Csf2rb G A 15: 78,340,492 R150H probably benign Het
Dhx35 T C 2: 158,831,864 L405P probably damaging Het
Dpf1 G A 7: 29,316,502 C383Y probably damaging Het
Dse T A 10: 34,155,993 Q345L probably benign Het
Gnaz A G 10: 75,014,874 M244V probably damaging Het
Gpr65 A T 12: 98,275,715 Y209F possibly damaging Het
Inpp5f T C 7: 128,667,769 I281T probably damaging Het
Kntc1 T C 5: 123,778,267 F721S probably damaging Het
Mapk8ip2 G A 15: 89,457,017 probably null Het
Med24 G A 11: 98,709,682 R646W probably damaging Het
Nup98 A T 7: 102,194,711 F102Y probably damaging Het
Olfr1260 G T 2: 89,977,978 V67L probably benign Het
Olfr150 A T 9: 39,737,666 M284L possibly damaging Het
Pgap3 T C 11: 98,397,954 Y125C probably damaging Het
Rasl12 T C 9: 65,408,362 V96A probably damaging Het
Rbm20 G A 19: 53,813,443 M127I probably damaging Het
Rnf114 T A 2: 167,512,626 probably null Het
Serpinb1b C T 13: 33,085,311 T9I possibly damaging Het
Setd1b T A 5: 123,163,426 F16I possibly damaging Het
Slc25a28 A G 19: 43,664,508 F238S probably damaging Het
Slc2a2 T C 3: 28,705,803 V30A probably damaging Het
Slc35f4 T C 14: 49,525,505 probably benign Het
Socs4 T A 14: 47,290,650 C347* probably null Het
Spock1 C T 13: 57,430,328 E367K probably damaging Het
Ubap2 C T 4: 41,251,608 R8H probably benign Het
Vmn1r44 T A 6: 89,893,824 M41K probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp575 T C 7: 24,585,815 T134A possibly damaging Het
Other mutations in Olfr354
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02573:Olfr354 APN 2 36907554 missense probably damaging 1.00
P0027:Olfr354 UTSW 2 36907570 missense probably benign 0.00
R0040:Olfr354 UTSW 2 36907458 missense probably damaging 1.00
R0610:Olfr354 UTSW 2 36907659 missense probably damaging 1.00
R0760:Olfr354 UTSW 2 36907221 missense probably benign 0.25
R1727:Olfr354 UTSW 2 36907393 missense probably benign 0.00
R2972:Olfr354 UTSW 2 36907404 missense probably benign 0.03
R4671:Olfr354 UTSW 2 36907393 missense probably benign 0.00
R4750:Olfr354 UTSW 2 36907716 missense probably benign 0.13
R5043:Olfr354 UTSW 2 36906965 missense probably benign 0.01
R5400:Olfr354 UTSW 2 36907821 missense probably damaging 1.00
R5543:Olfr354 UTSW 2 36907357 missense possibly damaging 0.75
R5792:Olfr354 UTSW 2 36907101 missense probably benign 0.00
R6639:Olfr354 UTSW 2 36907678 missense probably damaging 1.00
R6876:Olfr354 UTSW 2 36907822 missense probably damaging 1.00
T0722:Olfr354 UTSW 2 36907570 missense probably benign 0.00
Posted On2014-05-07