Incidental Mutation 'IGL01946:Dhx16'
| ID |
180966 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dhx16
|
| Ensembl Gene |
ENSMUSG00000024422 |
| Gene Name |
DEAH-box helicase 16 |
| Synonyms |
DBP2, DEAH (Asp-Glu-Ala-His) box polypeptide 16, Ddx16, 2410006N22Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL01946
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
36190711-36203562 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 36196396 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 521
(M521I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133888
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025292]
[ENSMUST00000174366]
|
| AlphaFold |
G3X8X0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000025292
AA Change: M521I
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000025292
Gene: ENSMUSG00000024422
AA Change: M521I
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:DEXDc
|
55 |
310 |
6e-57 |
BLAST |
|
DEXDc
|
400 |
585 |
7.26e-33 |
SMART |
|
HELICc
|
636 |
733 |
1.7e-15 |
SMART |
|
HA2
|
794 |
885 |
2.24e-31 |
SMART |
|
Pfam:OB_NTP_bind
|
901 |
1018 |
3.6e-24 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000172730
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173596
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173967
|
| SMART Domains |
Protein: ENSMUSP00000133818
Gene: ENSMUSG00000024422
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:DEXDc
|
2 |
83 |
5e-35 |
BLAST |
|
PDB:3I4U|A
|
4 |
83 |
6e-14 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174330
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174366
AA Change: M521I
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000133888
Gene: ENSMUSG00000024422
AA Change: M521I
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:DEXDc
|
55 |
310 |
9e-58 |
BLAST |
|
DEXDc
|
400 |
585 |
7.26e-33 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174449
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2ml1 |
C |
T |
6: 128,547,442 (GRCm39) |
E343K |
possibly damaging |
Het |
| Abcc9 |
T |
C |
6: 142,571,763 (GRCm39) |
I1087V |
probably benign |
Het |
| Bcam |
A |
C |
7: 19,494,042 (GRCm39) |
Y416* |
probably null |
Het |
| Bhlhe22 |
T |
A |
3: 18,109,960 (GRCm39) |
C337S |
probably damaging |
Het |
| Cerkl |
T |
C |
2: 79,223,364 (GRCm39) |
D119G |
probably benign |
Het |
| Cog6 |
T |
C |
3: 52,909,825 (GRCm39) |
|
probably benign |
Het |
| Dchs1 |
T |
C |
7: 105,408,312 (GRCm39) |
D1840G |
probably damaging |
Het |
| Dnaja2 |
A |
G |
8: 86,273,329 (GRCm39) |
I196T |
probably damaging |
Het |
| Fbxw7 |
T |
C |
3: 84,811,369 (GRCm39) |
Y165H |
possibly damaging |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm3371 |
A |
G |
14: 44,646,178 (GRCm39) |
Y96H |
probably damaging |
Het |
| H2-T10 |
G |
A |
17: 36,431,608 (GRCm39) |
A82V |
possibly damaging |
Het |
| Hydin |
A |
G |
8: 111,217,350 (GRCm39) |
T1413A |
possibly damaging |
Het |
| Krt23 |
T |
A |
11: 99,383,665 (GRCm39) |
M76L |
possibly damaging |
Het |
| Lipe |
A |
T |
7: 25,082,701 (GRCm39) |
M504K |
possibly damaging |
Het |
| Lrrc37 |
T |
A |
11: 103,503,759 (GRCm39) |
R560S |
probably benign |
Het |
| Lta4h |
T |
A |
10: 93,307,232 (GRCm39) |
|
probably benign |
Het |
| Ltbp2 |
T |
C |
12: 84,877,522 (GRCm39) |
T348A |
probably damaging |
Het |
| Mybpc2 |
C |
A |
7: 44,159,322 (GRCm39) |
|
probably benign |
Het |
| Or51r1 |
T |
C |
7: 102,227,734 (GRCm39) |
|
probably null |
Het |
| Or52r1b |
T |
A |
7: 102,691,357 (GRCm39) |
S219T |
probably damaging |
Het |
| Pdp2 |
G |
A |
8: 105,320,824 (GRCm39) |
M224I |
probably benign |
Het |
| Pimreg |
C |
T |
11: 71,935,804 (GRCm39) |
|
probably benign |
Het |
| Pld1 |
A |
T |
3: 28,178,766 (GRCm39) |
S887C |
probably damaging |
Het |
| Ppp1r3g |
G |
A |
13: 36,152,978 (GRCm39) |
A133T |
possibly damaging |
Het |
| Prpf8 |
G |
A |
11: 75,390,818 (GRCm39) |
G1323D |
probably damaging |
Het |
| Rab3ip |
A |
G |
10: 116,773,300 (GRCm39) |
|
probably null |
Het |
| Rpain |
A |
G |
11: 70,861,358 (GRCm39) |
H9R |
possibly damaging |
Het |
| Scin |
T |
C |
12: 40,110,490 (GRCm39) |
|
probably benign |
Het |
| Serpinb6d |
A |
G |
13: 33,855,369 (GRCm39) |
T348A |
probably benign |
Het |
| Smad3 |
A |
G |
9: 63,664,835 (GRCm39) |
L42P |
probably damaging |
Het |
| Smr3a |
C |
T |
5: 88,156,014 (GRCm39) |
|
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r13 |
G |
A |
5: 109,322,085 (GRCm39) |
T204I |
probably benign |
Het |
| Zfhx3 |
A |
G |
8: 109,660,561 (GRCm39) |
N1272D |
probably damaging |
Het |
|
| Other mutations in Dhx16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00949:Dhx16
|
APN |
17 |
36,198,826 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01533:Dhx16
|
APN |
17 |
36,192,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01743:Dhx16
|
APN |
17 |
36,199,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02170:Dhx16
|
APN |
17 |
36,200,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Dhx16
|
APN |
17 |
36,194,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02334:Dhx16
|
APN |
17 |
36,194,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02417:Dhx16
|
APN |
17 |
36,203,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0403:Dhx16
|
UTSW |
17 |
36,193,942 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0410:Dhx16
|
UTSW |
17 |
36,201,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0544:Dhx16
|
UTSW |
17 |
36,192,551 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0835:Dhx16
|
UTSW |
17 |
36,192,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0845:Dhx16
|
UTSW |
17 |
36,194,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Dhx16
|
UTSW |
17 |
36,201,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Dhx16
|
UTSW |
17 |
36,196,511 (GRCm39) |
missense |
probably benign |
0.36 |
|
R1905:Dhx16
|
UTSW |
17 |
36,199,247 (GRCm39) |
missense |
probably benign |
|
|
R2233:Dhx16
|
UTSW |
17 |
36,198,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2234:Dhx16
|
UTSW |
17 |
36,198,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4647:Dhx16
|
UTSW |
17 |
36,196,527 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4648:Dhx16
|
UTSW |
17 |
36,196,527 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4665:Dhx16
|
UTSW |
17 |
36,190,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dhx16
|
UTSW |
17 |
36,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4862:Dhx16
|
UTSW |
17 |
36,194,154 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5089:Dhx16
|
UTSW |
17 |
36,194,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5122:Dhx16
|
UTSW |
17 |
36,194,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5665:Dhx16
|
UTSW |
17 |
36,201,978 (GRCm39) |
nonsense |
probably null |
|
|
R5748:Dhx16
|
UTSW |
17 |
36,194,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Dhx16
|
UTSW |
17 |
36,192,580 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5956:Dhx16
|
UTSW |
17 |
36,193,762 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6001:Dhx16
|
UTSW |
17 |
36,194,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Dhx16
|
UTSW |
17 |
36,193,864 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6420:Dhx16
|
UTSW |
17 |
36,193,906 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6467:Dhx16
|
UTSW |
17 |
36,197,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7326:Dhx16
|
UTSW |
17 |
36,197,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7338:Dhx16
|
UTSW |
17 |
36,199,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7457:Dhx16
|
UTSW |
17 |
36,201,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7736:Dhx16
|
UTSW |
17 |
36,192,568 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8508:Dhx16
|
UTSW |
17 |
36,196,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8552:Dhx16
|
UTSW |
17 |
36,192,183 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8733:Dhx16
|
UTSW |
17 |
36,192,267 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8831:Dhx16
|
UTSW |
17 |
36,199,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9014:Dhx16
|
UTSW |
17 |
36,193,490 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9194:Dhx16
|
UTSW |
17 |
36,200,173 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9350:Dhx16
|
UTSW |
17 |
36,200,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Dhx16
|
UTSW |
17 |
36,193,413 (GRCm39) |
missense |
probably benign |
0.11 |
|
| Posted On |
2014-05-07 |
Incidental Mutation