Incidental Mutation 'IGL01941:Wdr26'
ID 181182
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr26
Ensembl Gene ENSMUSG00000038733
Gene Name WD repeat domain 26
Synonyms Gid7, 1600024A01Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.915) question?
Stock # IGL01941
Quality Score
Status
Chromosome 1
Chromosomal Location 181000793-181039566 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 181038635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162819] [ENSMUST00000162963]
AlphaFold Q8C6G8
Predicted Effect probably benign
Transcript: ENSMUST00000036329
SMART Domains Protein: ENSMUSP00000045177
Gene: ENSMUSG00000038733

DomainStartEndE-ValueType
low complexity region 1 16 N/A INTRINSIC
low complexity region 43 70 N/A INTRINSIC
low complexity region 71 83 N/A INTRINSIC
LisH 100 132 9.73e-1 SMART
Blast:CTLH 133 183 6e-28 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000162819
SMART Domains Protein: ENSMUSP00000124592
Gene: ENSMUSG00000038733

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
low complexity region 46 73 N/A INTRINSIC
low complexity region 74 86 N/A INTRINSIC
LisH 103 135 9.73e-1 SMART
CTLH 136 211 2.41e-5 SMART
low complexity region 276 287 N/A INTRINSIC
WD40 324 363 4.76e-6 SMART
WD40 370 411 1.35e-5 SMART
WD40 414 454 2.12e-3 SMART
WD40 537 579 2.77e-1 SMART
WD40 582 622 3.83e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162963
SMART Domains Protein: ENSMUSP00000124186
Gene: ENSMUSG00000038733

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
low complexity region 46 73 N/A INTRINSIC
low complexity region 74 86 N/A INTRINSIC
LisH 103 135 9.73e-1 SMART
CTLH 136 195 4.97e-7 SMART
low complexity region 260 271 N/A INTRINSIC
WD40 308 347 4.76e-6 SMART
WD40 354 395 1.35e-5 SMART
WD40 398 438 2.12e-3 SMART
WD40 521 563 2.77e-1 SMART
WD40 566 606 3.83e-10 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624G23Rik A T 12: 24,094,802 (GRCm39) L123Q probably benign Het
Abca2 C T 2: 25,333,107 (GRCm39) S1602F probably benign Het
Abcc9 C A 6: 142,551,630 (GRCm39) C1191F probably damaging Het
Adam3 G T 8: 25,171,462 (GRCm39) probably benign Het
Aldh1l1 G T 6: 90,539,677 (GRCm39) G202V probably damaging Het
Ankrd46 T C 15: 36,486,083 (GRCm39) N57D possibly damaging Het
Asic1 A T 15: 99,596,982 (GRCm39) H548L possibly damaging Het
Atpaf2 A G 11: 60,294,724 (GRCm39) I233T probably benign Het
Ccdc185 G T 1: 182,575,769 (GRCm39) Q307K probably benign Het
Cep120 T C 18: 53,856,220 (GRCm39) D399G probably benign Het
Cnn2 G A 10: 79,828,388 (GRCm39) V122M probably benign Het
Dgkd T C 1: 87,852,281 (GRCm39) S472P probably damaging Het
Dock5 A C 14: 68,049,681 (GRCm39) I701S probably damaging Het
Efl1 A G 7: 82,347,184 (GRCm39) E570G probably benign Het
Eln G A 5: 134,747,024 (GRCm39) probably benign Het
Fat2 A G 11: 55,202,831 (GRCm39) V81A probably benign Het
Fbxw21 T G 9: 108,977,224 (GRCm39) I162L probably benign Het
Fhl2 G A 1: 43,170,832 (GRCm39) Q161* probably null Het
Gabrg2 A G 11: 41,862,548 (GRCm39) Y179H probably damaging Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Grik5 A T 7: 24,764,607 (GRCm39) I152N probably damaging Het
H2-Ab1 A T 17: 34,486,408 (GRCm39) K156* probably null Het
Hecw1 T C 13: 14,490,895 (GRCm39) Y699C probably benign Het
Ipo9 A C 1: 135,335,811 (GRCm39) V202G possibly damaging Het
Itprid1 A G 6: 55,945,030 (GRCm39) R584G probably benign Het
Jmjd6 A T 11: 116,732,184 (GRCm39) probably null Het
Lama5 A G 2: 179,834,185 (GRCm39) I1416T possibly damaging Het
Matn1 T C 4: 130,679,572 (GRCm39) probably benign Het
Mavs T C 2: 131,088,525 (GRCm39) V443A probably damaging Het
Mpdz A T 4: 81,204,624 (GRCm39) S1798R possibly damaging Het
Muc6 A C 7: 141,218,497 (GRCm39) S2059A probably benign Het
Or4a78 A T 2: 89,497,812 (GRCm39) C139* probably null Het
Otud7b G T 3: 96,062,776 (GRCm39) G672C probably benign Het
Palld T A 8: 61,988,734 (GRCm39) T572S probably benign Het
Pde6b T A 5: 108,570,902 (GRCm39) V379E probably benign Het
Peak1 A G 9: 56,166,059 (GRCm39) V623A probably damaging Het
Prr12 C T 7: 44,698,083 (GRCm39) probably benign Het
Rxra T C 2: 27,644,253 (GRCm39) I315T probably damaging Het
Slc11a1 C T 1: 74,416,338 (GRCm39) A55V probably damaging Het
Slitrk3 T C 3: 72,958,404 (GRCm39) N123D possibly damaging Het
Smr2l A G 5: 88,430,301 (GRCm39) S66G probably benign Het
Spcs1 A G 14: 30,722,829 (GRCm39) M82T probably damaging Het
Sspo A G 6: 48,472,116 (GRCm39) E113G probably benign Het
Syne2 A G 12: 76,013,994 (GRCm39) K3062E probably benign Het
Traf3ip2 T C 10: 39,510,656 (GRCm39) S310P probably benign Het
Ubp1 T C 9: 113,785,826 (GRCm39) L167S probably damaging Het
Vmn1r196 T A 13: 22,477,869 (GRCm39) C169* probably null Het
Vmn1r223 T A 13: 23,434,407 (GRCm39) F334I possibly damaging Het
Vmn2r10 A T 5: 109,143,820 (GRCm39) I710N probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Wnt7a A G 6: 91,371,645 (GRCm39) F106L probably benign Het
Zfp940 C T 7: 29,546,295 (GRCm39) V34M probably damaging Het
Other mutations in Wdr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01625:Wdr26 APN 1 181,019,381 (GRCm39) missense possibly damaging 0.86
IGL02612:Wdr26 APN 1 181,005,361 (GRCm39) utr 3 prime probably benign
IGL02660:Wdr26 APN 1 181,026,463 (GRCm39) missense probably damaging 1.00
IGL02685:Wdr26 APN 1 181,011,345 (GRCm39) missense possibly damaging 0.64
IGL02884:Wdr26 APN 1 181,010,349 (GRCm39) missense probably damaging 1.00
R0396:Wdr26 UTSW 1 181,008,216 (GRCm39) intron probably benign
R0453:Wdr26 UTSW 1 181,010,444 (GRCm39) nonsense probably null
R0530:Wdr26 UTSW 1 181,013,635 (GRCm39) splice site probably null
R0729:Wdr26 UTSW 1 181,013,470 (GRCm39) splice site probably null
R1170:Wdr26 UTSW 1 181,008,859 (GRCm39) splice site probably benign
R1466:Wdr26 UTSW 1 181,013,499 (GRCm39) splice site probably benign
R1830:Wdr26 UTSW 1 181,019,340 (GRCm39) missense probably damaging 1.00
R2883:Wdr26 UTSW 1 181,038,685 (GRCm39) missense probably damaging 0.99
R4090:Wdr26 UTSW 1 181,030,679 (GRCm39) missense probably damaging 1.00
R4097:Wdr26 UTSW 1 181,010,352 (GRCm39) missense probably benign 0.00
R4953:Wdr26 UTSW 1 181,025,216 (GRCm39) missense probably damaging 1.00
R5223:Wdr26 UTSW 1 181,015,251 (GRCm39) missense probably benign 0.07
R5834:Wdr26 UTSW 1 181,030,712 (GRCm39) missense probably damaging 1.00
R5884:Wdr26 UTSW 1 181,015,106 (GRCm39) intron probably benign
R6174:Wdr26 UTSW 1 181,019,433 (GRCm39) missense probably damaging 1.00
R6334:Wdr26 UTSW 1 181,030,771 (GRCm39)
R7161:Wdr26 UTSW 1 181,030,695 (GRCm39) missense probably damaging 1.00
R7255:Wdr26 UTSW 1 181,008,889 (GRCm39) missense probably benign 0.24
R7406:Wdr26 UTSW 1 181,015,240 (GRCm39) missense probably damaging 1.00
R7804:Wdr26 UTSW 1 181,010,387 (GRCm39) missense probably damaging 1.00
R7815:Wdr26 UTSW 1 181,036,638 (GRCm39) missense probably benign 0.28
R8717:Wdr26 UTSW 1 181,011,913 (GRCm39) missense possibly damaging 0.92
R9072:Wdr26 UTSW 1 181,010,351 (GRCm39) missense probably damaging 0.99
R9358:Wdr26 UTSW 1 181,019,423 (GRCm39) missense probably damaging 0.98
R9520:Wdr26 UTSW 1 181,036,587 (GRCm39) missense probably benign 0.06
R9523:Wdr26 UTSW 1 181,013,620 (GRCm39) missense probably benign 0.38
R9719:Wdr26 UTSW 1 181,015,224 (GRCm39) missense possibly damaging 0.89
R9793:Wdr26 UTSW 1 181,036,812 (GRCm39) missense probably damaging 0.98
R9795:Wdr26 UTSW 1 181,036,812 (GRCm39) missense probably damaging 0.98
Posted On 2014-05-07