Incidental Mutation 'IGL01947:Adgrl4'
ID181285
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgrl4
Ensembl Gene ENSMUSG00000039167
Gene Nameadhesion G protein-coupled receptor L4
SynonymsEltd1, Etl, EGF-TM7 receptor, 1110033N21Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01947
Quality Score
Status
Chromosome3
Chromosomal Location151437887-151545086 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 151510791 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000041939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046977]
Predicted Effect probably null
Transcript: ENSMUST00000046977
SMART Domains Protein: ENSMUSP00000041939
Gene: ENSMUSG00000039167

DomainStartEndE-ValueType
EGF 21 57 9.13e0 SMART
EGF_CA 58 107 4.88e-9 SMART
EGF_CA 108 157 4.88e-9 SMART
Pfam:GAIN 182 390 6.8e-38 PFAM
GPS 414 467 1.25e-17 SMART
Pfam:7tm_2 473 709 2.5e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129283
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: For a targeted mutation, no significant differences were detected between homozygous mice and controls in a high-throughput screen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aloxe3 T A 11: 69,143,021 probably benign Het
Atic C T 1: 71,570,837 probably benign Het
Avpr1a T C 10: 122,452,182 V365A probably benign Het
Brd7 A G 8: 88,332,875 probably benign Het
Cc2d2a A G 5: 43,688,237 N332D probably damaging Het
Cdh20 C T 1: 104,993,924 P649S possibly damaging Het
Cgnl1 T C 9: 71,725,044 T342A probably damaging Het
Chst10 A G 1: 38,865,565 L349P probably damaging Het
Cox6b2 T A 7: 4,751,930 K77* probably null Het
Crnkl1 G A 2: 145,921,824 A498V probably benign Het
Cux1 A G 5: 136,275,125 L1394P probably benign Het
Dapp1 T C 3: 137,935,643 Y197C probably damaging Het
Dcc A G 18: 71,826,209 I164T probably benign Het
Disp3 T A 4: 148,260,519 I472F probably damaging Het
Gm10392 A T 11: 77,517,480 D104E probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gpd1 A G 15: 99,720,231 I143V possibly damaging Het
Hmcn1 T A 1: 150,732,892 N1513I possibly damaging Het
Jakmip2 T C 18: 43,547,094 I733V probably benign Het
Klhl12 T A 1: 134,463,951 L107H probably damaging Het
Lcn8 A G 2: 25,655,145 D109G probably damaging Het
Maz A T 7: 127,024,442 probably null Het
Mttp T A 3: 138,107,129 D595V probably damaging Het
Mymk A C 2: 27,066,394 L58R possibly damaging Het
Nckap1 A C 2: 80,508,753 I977S probably damaging Het
Nckap1l A T 15: 103,491,015 I1021F probably benign Het
Olfr102 A T 17: 37,313,665 C240S probably damaging Het
Olfr1307 A T 2: 111,944,994 M154K probably benign Het
Olfr1310 A T 2: 112,009,016 S57T possibly damaging Het
Olfr768 G A 10: 129,093,878 T32I possibly damaging Het
Pde5a T A 3: 122,835,610 F644L probably damaging Het
Pdzd2 A G 15: 12,592,354 I68T probably damaging Het
Pik3r4 T A 9: 105,686,150 V1242D possibly damaging Het
Ppp6r2 G T 15: 89,278,726 W517L probably damaging Het
Scrib A T 15: 76,061,767 I703K probably benign Het
Serpina1b T C 12: 103,729,317 S322G probably benign Het
Siglecg C A 7: 43,408,763 Q25K probably benign Het
Slc12a3 G A 8: 94,365,819 probably null Het
Slc6a13 G T 6: 121,325,157 probably null Het
Stard13 A T 5: 151,062,844 D282E probably damaging Het
Tpte A T 8: 22,355,473 Y513F possibly damaging Het
Ubox5 T A 2: 130,600,659 K36I possibly damaging Het
Other mutations in Adgrl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Adgrl4 APN 3 151542841 missense probably damaging 1.00
IGL00694:Adgrl4 APN 3 151439396 splice site probably benign
IGL01143:Adgrl4 APN 3 151500229 splice site probably null
IGL01359:Adgrl4 APN 3 151543286 missense probably damaging 1.00
IGL02149:Adgrl4 APN 3 151500354 missense possibly damaging 0.95
IGL02324:Adgrl4 APN 3 151497874 missense probably damaging 1.00
IGL02562:Adgrl4 APN 3 151439312 missense probably damaging 1.00
IGL02644:Adgrl4 APN 3 151492370 missense probably benign 0.00
trivial UTSW 3 151517610 missense probably benign 0.07
R0077:Adgrl4 UTSW 3 151517781 missense probably damaging 1.00
R0116:Adgrl4 UTSW 3 151517610 missense probably benign 0.07
R0331:Adgrl4 UTSW 3 151497940 missense probably benign 0.00
R0601:Adgrl4 UTSW 3 151498429 splice site probably benign
R0613:Adgrl4 UTSW 3 151543222 splice site probably benign
R1293:Adgrl4 UTSW 3 151507444 missense probably benign 0.00
R1463:Adgrl4 UTSW 3 151510596 missense probably damaging 0.98
R1697:Adgrl4 UTSW 3 151517611 missense probably damaging 1.00
R1731:Adgrl4 UTSW 3 151540986 missense possibly damaging 0.64
R1765:Adgrl4 UTSW 3 151543235 missense probably damaging 1.00
R1782:Adgrl4 UTSW 3 151542805 nonsense probably null
R1888:Adgrl4 UTSW 3 151439277 missense probably benign 0.11
R1888:Adgrl4 UTSW 3 151439277 missense probably benign 0.11
R1957:Adgrl4 UTSW 3 151510779 missense possibly damaging 0.94
R2128:Adgrl4 UTSW 3 151500201 missense probably benign 0.00
R2180:Adgrl4 UTSW 3 151500142 missense probably damaging 0.96
R2238:Adgrl4 UTSW 3 151500142 missense probably damaging 0.96
R2474:Adgrl4 UTSW 3 151542724 missense probably benign 0.01
R2697:Adgrl4 UTSW 3 151510623 missense probably damaging 1.00
R3835:Adgrl4 UTSW 3 151510617 missense probably damaging 1.00
R4499:Adgrl4 UTSW 3 151510785 missense possibly damaging 0.81
R4640:Adgrl4 UTSW 3 151500310 unclassified probably benign
R4747:Adgrl4 UTSW 3 151507440 missense probably benign 0.01
R5428:Adgrl4 UTSW 3 151542686 missense probably damaging 1.00
R5510:Adgrl4 UTSW 3 151497830 missense possibly damaging 0.89
R5717:Adgrl4 UTSW 3 151492334 missense probably benign 0.01
R6106:Adgrl4 UTSW 3 151540985 missense possibly damaging 0.67
R6343:Adgrl4 UTSW 3 151517806 missense probably damaging 1.00
R6419:Adgrl4 UTSW 3 151439316 missense probably damaging 1.00
R6468:Adgrl4 UTSW 3 151492375 missense probably benign
R6636:Adgrl4 UTSW 3 151517773 nonsense probably null
R6637:Adgrl4 UTSW 3 151517773 nonsense probably null
R6687:Adgrl4 UTSW 3 151542755 missense probably benign 0.00
R6856:Adgrl4 UTSW 3 151500118 missense probably benign 0.00
R6887:Adgrl4 UTSW 3 151542733 missense possibly damaging 0.46
R7041:Adgrl4 UTSW 3 151439322 missense probably benign 0.00
X0053:Adgrl4 UTSW 3 151497833 missense probably damaging 1.00
Z1088:Adgrl4 UTSW 3 151500175 missense probably benign 0.00
Posted On2014-05-07