Incidental Mutation 'IGL01950:Zfp958'
| ID |
181306 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp958
|
| Ensembl Gene |
ENSMUSG00000058748 |
| Gene Name |
zinc finger protein 958 |
| Synonyms |
BC003267 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
IGL01950
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
4663167-4680231 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 4678917 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 314
(L314P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073201]
[ENSMUST00000202692]
|
| AlphaFold |
Q99LG7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073201
AA Change: L313P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000072937
Gene: ENSMUSG00000058748
AA Change: L313P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
65 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
102 |
124 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
130 |
152 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
158 |
180 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
186 |
208 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
214 |
236 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
242 |
264 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
354 |
376 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
382 |
404 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
410 |
432 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
438 |
460 |
6.88e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202692
AA Change: L314P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000143842
Gene: ENSMUSG00000058748
AA Change: L314P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
6.88e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adm |
G |
A |
7: 110,228,107 (GRCm39) |
R96H |
probably damaging |
Het |
| Aebp1 |
C |
T |
11: 5,819,108 (GRCm39) |
T198I |
probably benign |
Het |
| Arid3b |
A |
T |
9: 57,702,257 (GRCm39) |
I500N |
probably damaging |
Het |
| Clec1b |
T |
A |
6: 129,377,043 (GRCm39) |
W29R |
probably damaging |
Het |
| Cyp2e1 |
T |
C |
7: 140,344,874 (GRCm39) |
|
probably null |
Het |
| Dnah5 |
A |
G |
15: 28,290,435 (GRCm39) |
E1275G |
probably null |
Het |
| Dnajc13 |
A |
T |
9: 104,067,631 (GRCm39) |
I1171N |
possibly damaging |
Het |
| Dpf3 |
T |
G |
12: 83,371,723 (GRCm39) |
T171P |
probably benign |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Hk1 |
T |
C |
10: 62,151,173 (GRCm39) |
D57G |
probably damaging |
Het |
| Kcnc2 |
T |
G |
10: 112,297,980 (GRCm39) |
|
probably benign |
Het |
| Kcnj11 |
A |
T |
7: 45,748,573 (GRCm39) |
F250Y |
probably damaging |
Het |
| Kirrel3 |
C |
T |
9: 34,939,625 (GRCm39) |
|
probably benign |
Het |
| Lmbrd1 |
T |
C |
1: 24,750,683 (GRCm39) |
|
probably null |
Het |
| Mga |
T |
C |
2: 119,772,135 (GRCm39) |
V1665A |
possibly damaging |
Het |
| Ms4a3 |
G |
T |
19: 11,610,199 (GRCm39) |
A121E |
probably damaging |
Het |
| Nfix |
T |
C |
8: 85,440,415 (GRCm39) |
*392W |
probably null |
Het |
| Noxred1 |
C |
T |
12: 87,268,190 (GRCm39) |
V314M |
probably damaging |
Het |
| Or2t47 |
A |
T |
11: 58,442,560 (GRCm39) |
C168* |
probably null |
Het |
| Or51aa5 |
T |
A |
7: 103,167,472 (GRCm39) |
T40S |
probably benign |
Het |
| Phospho1 |
A |
G |
11: 95,719,548 (GRCm39) |
|
probably benign |
Het |
| Prr5 |
G |
A |
15: 84,650,550 (GRCm39) |
A237T |
probably benign |
Het |
| Rev3l |
C |
T |
10: 39,697,153 (GRCm39) |
T550M |
probably damaging |
Het |
| Sbf2 |
A |
G |
7: 109,965,032 (GRCm39) |
F955L |
probably benign |
Het |
| Slc38a9 |
C |
T |
13: 112,831,787 (GRCm39) |
T179M |
probably damaging |
Het |
| Trpv5 |
T |
G |
6: 41,652,912 (GRCm39) |
D87A |
probably benign |
Het |
| Tubgcp5 |
A |
G |
7: 55,455,836 (GRCm39) |
Q288R |
possibly damaging |
Het |
| Uqcc1 |
A |
G |
2: 155,700,058 (GRCm39) |
Y172H |
probably damaging |
Het |
| Vmn2r23 |
T |
C |
6: 123,718,845 (GRCm39) |
F733L |
possibly damaging |
Het |
| Vmn2r71 |
A |
G |
7: 85,264,827 (GRCm39) |
Y53C |
probably damaging |
Het |
| Vwa5a |
T |
A |
9: 38,638,266 (GRCm39) |
M263K |
probably damaging |
Het |
| Zfp503 |
C |
A |
14: 22,036,488 (GRCm39) |
A143S |
probably benign |
Het |
|
| Other mutations in Zfp958 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02185:Zfp958
|
APN |
8 |
4,678,990 (GRCm39) |
nonsense |
probably null |
|
|
IGL02716:Zfp958
|
APN |
8 |
4,675,967 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1118:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1119:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1478:Zfp958
|
UTSW |
8 |
4,679,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Zfp958
|
UTSW |
8 |
4,679,147 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1837:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3763:Zfp958
|
UTSW |
8 |
4,676,226 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5257:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5258:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5304:Zfp958
|
UTSW |
8 |
4,676,196 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5512:Zfp958
|
UTSW |
8 |
4,675,838 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5907:Zfp958
|
UTSW |
8 |
4,679,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6604:Zfp958
|
UTSW |
8 |
4,678,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6688:Zfp958
|
UTSW |
8 |
4,678,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6727:Zfp958
|
UTSW |
8 |
4,678,247 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6981:Zfp958
|
UTSW |
8 |
4,676,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7010:Zfp958
|
UTSW |
8 |
4,678,377 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7140:Zfp958
|
UTSW |
8 |
4,678,481 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8096:Zfp958
|
UTSW |
8 |
4,663,273 (GRCm39) |
start gained |
probably benign |
|
|
R8491:Zfp958
|
UTSW |
8 |
4,676,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8673:Zfp958
|
UTSW |
8 |
4,678,268 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8847:Zfp958
|
UTSW |
8 |
4,678,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9612:Zfp958
|
UTSW |
8 |
4,678,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation