MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008] PHENOTYPE: Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury. [provided by MGI curators]
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Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl4fm4 |
A |
T |
4: 144,396,741 (GRCm39) |
D330E |
probably damaging |
Het |
Acsm3 |
T |
C |
7: 119,374,306 (GRCm39) |
|
probably benign |
Het |
Ankrd26 |
T |
A |
6: 118,535,966 (GRCm39) |
Y156F |
possibly damaging |
Het |
Bcr |
G |
A |
10: 75,011,173 (GRCm39) |
|
probably null |
Het |
Cpn2 |
C |
T |
16: 30,079,138 (GRCm39) |
A188T |
probably benign |
Het |
Ctdsp1 |
T |
C |
1: 74,433,242 (GRCm39) |
|
probably benign |
Het |
Cts7 |
T |
A |
13: 61,500,637 (GRCm39) |
R303S |
probably benign |
Het |
Dock7 |
T |
C |
4: 98,971,388 (GRCm39) |
D59G |
probably damaging |
Het |
Garre1 |
A |
T |
7: 33,944,460 (GRCm39) |
W91R |
probably damaging |
Het |
Gpr149 |
T |
C |
3: 62,438,348 (GRCm39) |
N603S |
probably benign |
Het |
Gucy2g |
A |
G |
19: 55,187,123 (GRCm39) |
I1099T |
probably benign |
Het |
Gzf1 |
G |
A |
2: 148,525,981 (GRCm39) |
A151T |
probably benign |
Het |
Ighv1-80 |
A |
T |
12: 115,876,253 (GRCm39) |
V21D |
probably benign |
Het |
Klhl18 |
T |
C |
9: 110,257,934 (GRCm39) |
Y432C |
probably damaging |
Het |
Lama4 |
A |
G |
10: 38,963,295 (GRCm39) |
D1289G |
probably benign |
Het |
Mab21l4 |
T |
A |
1: 93,079,794 (GRCm39) |
D432V |
probably damaging |
Het |
Mcm7 |
T |
C |
5: 138,165,507 (GRCm39) |
T466A |
probably damaging |
Het |
Megf8 |
A |
G |
7: 25,048,439 (GRCm39) |
E1704G |
possibly damaging |
Het |
Mettl25 |
C |
T |
10: 105,659,068 (GRCm39) |
C405Y |
probably damaging |
Het |
Muc6 |
A |
C |
7: 141,218,497 (GRCm39) |
S2059A |
probably benign |
Het |
Ndc1 |
T |
A |
4: 107,253,001 (GRCm39) |
I590N |
probably damaging |
Het |
Npnt |
G |
T |
3: 132,615,724 (GRCm39) |
N137K |
probably damaging |
Het |
Numa1 |
C |
T |
7: 101,645,300 (GRCm39) |
R309* |
probably null |
Het |
Ogfod3 |
G |
A |
11: 121,093,851 (GRCm39) |
T53I |
probably benign |
Het |
Or11i1 |
A |
G |
3: 106,729,311 (GRCm39) |
I188T |
possibly damaging |
Het |
Or5v1 |
C |
A |
17: 37,809,540 (GRCm39) |
|
probably benign |
Het |
Pcdhb9 |
G |
T |
18: 37,534,794 (GRCm39) |
V263F |
probably damaging |
Het |
Pld4 |
T |
C |
12: 112,734,355 (GRCm39) |
|
probably null |
Het |
Ppp2r3c |
A |
G |
12: 55,339,353 (GRCm39) |
L170P |
probably damaging |
Het |
Prex2 |
T |
A |
1: 11,210,235 (GRCm39) |
D558E |
possibly damaging |
Het |
Rasal2 |
A |
G |
1: 157,005,269 (GRCm39) |
S227P |
possibly damaging |
Het |
Rasal2 |
A |
T |
1: 157,003,686 (GRCm39) |
D324E |
probably damaging |
Het |
Rcbtb1 |
A |
G |
14: 59,467,416 (GRCm39) |
Y418C |
probably damaging |
Het |
Rhag |
T |
C |
17: 41,139,341 (GRCm39) |
F92S |
possibly damaging |
Het |
Scel |
T |
C |
14: 103,840,678 (GRCm39) |
|
probably benign |
Het |
Serinc5 |
A |
G |
13: 92,819,441 (GRCm39) |
N125S |
probably damaging |
Het |
Sgpl1 |
A |
T |
10: 60,936,672 (GRCm39) |
M561K |
probably benign |
Het |
Them6 |
A |
G |
15: 74,593,538 (GRCm39) |
Y132C |
probably damaging |
Het |
Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
Vmn2r27 |
A |
T |
6: 124,169,207 (GRCm39) |
F641Y |
probably damaging |
Het |
Vps13c |
A |
G |
9: 67,876,580 (GRCm39) |
Y3384C |
probably damaging |
Het |
Zbtb32 |
G |
T |
7: 30,289,353 (GRCm39) |
|
probably null |
Het |
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Other mutations in Sostdc1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0588:Sostdc1
|
UTSW |
12 |
36,367,020 (GRCm39) |
splice site |
probably benign |
|
R0671:Sostdc1
|
UTSW |
12 |
36,367,340 (GRCm39) |
missense |
probably damaging |
0.99 |
R2184:Sostdc1
|
UTSW |
12 |
36,367,295 (GRCm39) |
missense |
probably damaging |
0.97 |
R4320:Sostdc1
|
UTSW |
12 |
36,367,419 (GRCm39) |
missense |
probably benign |
0.04 |
R4480:Sostdc1
|
UTSW |
12 |
36,367,165 (GRCm39) |
missense |
probably damaging |
0.99 |
R5511:Sostdc1
|
UTSW |
12 |
36,367,165 (GRCm39) |
missense |
probably damaging |
1.00 |
R5589:Sostdc1
|
UTSW |
12 |
36,367,246 (GRCm39) |
nonsense |
probably null |
|
R5665:Sostdc1
|
UTSW |
12 |
36,364,407 (GRCm39) |
missense |
probably benign |
0.39 |
R6453:Sostdc1
|
UTSW |
12 |
36,364,407 (GRCm39) |
missense |
probably benign |
0.39 |
R6752:Sostdc1
|
UTSW |
12 |
36,364,411 (GRCm39) |
missense |
probably benign |
0.00 |
R7232:Sostdc1
|
UTSW |
12 |
36,367,310 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8810:Sostdc1
|
UTSW |
12 |
36,367,229 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9019:Sostdc1
|
UTSW |
12 |
36,364,431 (GRCm39) |
missense |
probably benign |
0.07 |
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