Incidental Mutation 'IGL01964:Cdyl2'
| ID |
181509 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cdyl2
|
| Ensembl Gene |
ENSMUSG00000031758 |
| Gene Name |
chromodomain protein, Y chromosome-like 2 |
| Synonyms |
1700029M19Rik, 4930453I21Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.122)
|
| Stock # |
IGL01964
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
117301139-117459730 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 117350768 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Leucine
at position 121
(S121L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109102]
|
| AlphaFold |
Q9D5D8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109102
AA Change: S121L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000104730
Gene: ENSMUSG00000031758
AA Change: S121L
| Domain | Start | End | E-Value | Type |
|---|
|
CHROMO
|
6 |
60 |
1.25e-17 |
SMART |
|
Pfam:ECH_1
|
252 |
499 |
5e-33 |
PFAM |
|
Pfam:ECH_2
|
258 |
501 |
1.6e-14 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam34l |
A |
C |
8: 44,079,798 (GRCm39) |
I142S |
probably benign |
Het |
| Aknad1 |
T |
C |
3: 108,685,593 (GRCm39) |
V579A |
probably benign |
Het |
| Ankrd11 |
A |
G |
8: 123,616,475 (GRCm39) |
I2438T |
probably damaging |
Het |
| Cdh11 |
A |
G |
8: 103,391,375 (GRCm39) |
V287A |
probably benign |
Het |
| Cyp2e1 |
A |
T |
7: 140,343,779 (GRCm39) |
I6F |
probably damaging |
Het |
| Cyp3a16 |
A |
T |
5: 145,392,372 (GRCm39) |
D194E |
probably benign |
Het |
| Eapp |
G |
T |
12: 54,732,720 (GRCm39) |
P126Q |
probably damaging |
Het |
| Efr3b |
A |
T |
12: 4,032,928 (GRCm39) |
L143Q |
probably damaging |
Het |
| Grin2c |
C |
T |
11: 115,144,673 (GRCm39) |
E618K |
probably damaging |
Het |
| Haus3 |
A |
T |
5: 34,323,405 (GRCm39) |
Y402N |
probably benign |
Het |
| Iffo1 |
A |
G |
6: 125,128,364 (GRCm39) |
D316G |
probably damaging |
Het |
| Kctd19 |
A |
T |
8: 106,115,157 (GRCm39) |
M468K |
probably damaging |
Het |
| Kdm4b |
T |
A |
17: 56,696,256 (GRCm39) |
|
probably null |
Het |
| Naip6 |
T |
A |
13: 100,435,238 (GRCm39) |
|
probably benign |
Het |
| Or5k15 |
A |
T |
16: 58,709,827 (GRCm39) |
I252K |
probably damaging |
Het |
| Polr3c |
T |
C |
3: 96,619,291 (GRCm39) |
|
probably benign |
Het |
| Poteg |
A |
T |
8: 27,938,036 (GRCm39) |
E60V |
probably damaging |
Het |
| Rnd2 |
T |
C |
11: 101,361,632 (GRCm39) |
|
probably null |
Het |
| Rufy3 |
A |
G |
5: 88,762,929 (GRCm39) |
Q153R |
probably damaging |
Het |
| Shank1 |
T |
A |
7: 43,975,102 (GRCm39) |
I399N |
unknown |
Het |
| Sin3a |
T |
C |
9: 57,014,631 (GRCm39) |
|
probably benign |
Het |
| Sppl2b |
T |
A |
10: 80,701,220 (GRCm39) |
|
probably null |
Het |
| Srgap1 |
G |
A |
10: 121,640,871 (GRCm39) |
P665L |
possibly damaging |
Het |
| Srgap2 |
G |
T |
1: 131,217,316 (GRCm39) |
Q999K |
probably benign |
Het |
| Tbxas1 |
G |
A |
6: 39,060,748 (GRCm39) |
V496I |
probably benign |
Het |
| Vmn1r198 |
A |
G |
13: 22,538,576 (GRCm39) |
M21V |
probably benign |
Het |
| Wdr90 |
T |
C |
17: 26,067,383 (GRCm39) |
I1479V |
probably benign |
Het |
|
| Other mutations in Cdyl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00953:Cdyl2
|
APN |
8 |
117,321,928 (GRCm39) |
splice site |
probably benign |
|
|
IGL01670:Cdyl2
|
APN |
8 |
117,351,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02148:Cdyl2
|
APN |
8 |
117,315,983 (GRCm39) |
splice site |
probably benign |
|
|
IGL02186:Cdyl2
|
APN |
8 |
117,306,025 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Allein
|
UTSW |
8 |
117,305,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Cdyl2
|
UTSW |
8 |
117,309,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cdyl2
|
UTSW |
8 |
117,350,774 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1430:Cdyl2
|
UTSW |
8 |
117,306,056 (GRCm39) |
splice site |
probably benign |
|
|
R1883:Cdyl2
|
UTSW |
8 |
117,321,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2326:Cdyl2
|
UTSW |
8 |
117,350,537 (GRCm39) |
missense |
probably benign |
|
|
R4194:Cdyl2
|
UTSW |
8 |
117,305,903 (GRCm39) |
splice site |
probably null |
|
|
R4916:Cdyl2
|
UTSW |
8 |
117,305,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4977:Cdyl2
|
UTSW |
8 |
117,302,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5092:Cdyl2
|
UTSW |
8 |
117,350,679 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R5320:Cdyl2
|
UTSW |
8 |
117,321,794 (GRCm39) |
nonsense |
probably null |
|
|
R5727:Cdyl2
|
UTSW |
8 |
117,309,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5830:Cdyl2
|
UTSW |
8 |
117,321,823 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6077:Cdyl2
|
UTSW |
8 |
117,316,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6086:Cdyl2
|
UTSW |
8 |
117,316,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6145:Cdyl2
|
UTSW |
8 |
117,321,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Cdyl2
|
UTSW |
8 |
117,309,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7152:Cdyl2
|
UTSW |
8 |
117,351,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Cdyl2
|
UTSW |
8 |
117,350,733 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7244:Cdyl2
|
UTSW |
8 |
117,301,999 (GRCm39) |
nonsense |
probably null |
|
|
R7394:Cdyl2
|
UTSW |
8 |
117,350,790 (GRCm39) |
missense |
not run |
|
|
R7457:Cdyl2
|
UTSW |
8 |
117,305,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8770:Cdyl2
|
UTSW |
8 |
117,321,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Cdyl2
|
UTSW |
8 |
117,350,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation