Incidental Mutation 'IGL01964:Polr3c'
ID181519
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Polr3c
Ensembl Gene ENSMUSG00000028099
Gene Namepolymerase (RNA) III (DNA directed) polypeptide C
Synonyms4933407E01Rik, RPC62, RPC3
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.950) question?
Stock #IGL01964
Quality Score
Status
Chromosome3
Chromosomal Location96711490-96727628 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 96711975 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029741] [ENSMUST00000029742] [ENSMUST00000154679] [ENSMUST00000171249] [ENSMUST00000200387]
Predicted Effect probably benign
Transcript: ENSMUST00000029741
SMART Domains Protein: ENSMUSP00000029741
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:HTH_9 7 68 9.4e-26 PFAM
Pfam:RNA_pol_Rpc82 146 344 7.6e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000029742
SMART Domains Protein: ENSMUSP00000029742
Gene: ENSMUSG00000028100

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:NUDIX 92 252 2.2e-9 PFAM
low complexity region 273 288 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128918
SMART Domains Protein: ENSMUSP00000119236
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:RNA_pol_Rpc82 20 180 5.9e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154679
SMART Domains Protein: ENSMUSP00000122435
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:HTH_9 7 68 1.6e-26 PFAM
Pfam:RNA_pol_Rpc82 146 344 7.6e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171249
SMART Domains Protein: ENSMUSP00000129851
Gene: ENSMUSG00000028100

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:NUDIX 92 235 1.2e-18 PFAM
low complexity region 256 271 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196773
Predicted Effect probably benign
Transcript: ENSMUST00000200387
SMART Domains Protein: ENSMUSP00000142879
Gene: ENSMUSG00000028100

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:NUDIX 79 125 4.2e-6 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aknad1 T C 3: 108,778,277 V579A probably benign Het
Ankrd11 A G 8: 122,889,736 I2438T probably damaging Het
Cdh11 A G 8: 102,664,743 V287A probably benign Het
Cdyl2 G A 8: 116,624,029 S121L probably benign Het
Cyp2e1 A T 7: 140,763,866 I6F probably damaging Het
Cyp3a16 A T 5: 145,455,562 D194E probably benign Het
Eapp G T 12: 54,685,935 P126Q probably damaging Het
Efr3b A T 12: 3,982,928 L143Q probably damaging Het
Gm5346 A C 8: 43,626,761 I142S probably benign Het
Grin2c C T 11: 115,253,847 E618K probably damaging Het
Haus3 A T 5: 34,166,061 Y402N probably benign Het
Iffo1 A G 6: 125,151,401 D316G probably damaging Het
Kctd19 A T 8: 105,388,525 M468K probably damaging Het
Kdm4b T A 17: 56,389,256 probably null Het
Naip6 T A 13: 100,298,730 probably benign Het
Olfr178 A T 16: 58,889,464 I252K probably damaging Het
Poteg A T 8: 27,448,008 E60V probably damaging Het
Rnd2 T C 11: 101,470,806 probably null Het
Rufy3 A G 5: 88,615,070 Q153R probably damaging Het
Shank1 T A 7: 44,325,678 I399N unknown Het
Sin3a T C 9: 57,107,347 probably benign Het
Sppl2b T A 10: 80,865,386 probably null Het
Srgap1 G A 10: 121,804,966 P665L possibly damaging Het
Srgap2 G T 1: 131,289,578 Q999K probably benign Het
Tbxas1 G A 6: 39,083,814 V496I probably benign Het
Vmn1r198 A G 13: 22,354,406 M21V probably benign Het
Wdr90 T C 17: 25,848,409 I1479V probably benign Het
Other mutations in Polr3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Polr3c APN 3 96713520 missense probably damaging 1.00
IGL01904:Polr3c APN 3 96716665 critical splice donor site probably null
IGL02640:Polr3c APN 3 96716686 missense probably damaging 0.98
IGL02955:Polr3c APN 3 96714312 missense probably damaging 1.00
IGL03129:Polr3c APN 3 96719454 splice site probably benign
IGL03263:Polr3c APN 3 96714251 splice site probably benign
R0503:Polr3c UTSW 3 96713636 splice site probably null
R0800:Polr3c UTSW 3 96719311 missense probably damaging 0.99
R0881:Polr3c UTSW 3 96723847 missense probably damaging 0.99
R1763:Polr3c UTSW 3 96713595 missense probably damaging 1.00
R1931:Polr3c UTSW 3 96719298 missense probably damaging 1.00
R1932:Polr3c UTSW 3 96719298 missense probably damaging 1.00
R1994:Polr3c UTSW 3 96714373 splice site probably null
R3771:Polr3c UTSW 3 96725854 missense probably damaging 1.00
R4116:Polr3c UTSW 3 96715244 missense probably damaging 1.00
R4614:Polr3c UTSW 3 96716471 missense probably benign 0.00
R4732:Polr3c UTSW 3 96723661 missense probably damaging 1.00
R4733:Polr3c UTSW 3 96723661 missense probably damaging 1.00
R5057:Polr3c UTSW 3 96712057 missense probably damaging 0.98
R5058:Polr3c UTSW 3 96723517 missense probably benign 0.01
R5756:Polr3c UTSW 3 96714134 missense probably damaging 1.00
R6005:Polr3c UTSW 3 96719468 missense possibly damaging 0.96
R6009:Polr3c UTSW 3 96713614 missense probably damaging 1.00
R6580:Polr3c UTSW 3 96727343 splice site probably null
R7003:Polr3c UTSW 3 96723638 missense possibly damaging 0.94
Posted On2014-05-07